Prof. Manuel Mayr

Prof. Manuel Mayr

Prof. Manuel Mayr qualified in Medicine from the University of Innsbruck (Austria) in 1999, where he graduated “sub ausspiciis praesidentis”, the highest distinction awarded for academic education. He soon decided that his interests lay in research and therefore took up full-time research training in 2001, when he moved to St George’s Hospital Medical School to undertake a PhD with Professor Qingbo Xu. His PhD was awarded by the University of London in 2005, on the topic of “Cardiovascular Proteomics: Linking Proteomic and Metabolomic Changes”. He obtained a BHF Intermediate Research Fellowship in 2005 and in 2006 moved to King’s College London as Lecturer in the Cardiovascular Division. In 2008, he was successful in obtaining a BHF Senior Research Fellowship and this was recently renewed for a second term. In parallel, he achieved promotion to Senior Lecturer in 2008, to Reader in 2010, and to Professor in 2011.

His academic achievements have been recognised by the inaugural Michael Davies Early Career Award of the British Cardiovascular Society (2007), the inaugural Bernard and Joan Marshall Research Excellence Prize of the British Society for Cardiovascular Research (2010), and the Outstanding Achievement Award by the European Society of Cardiology Council for Basic Cardiovascular Science (2013).

Education


1992-1998 Medical School, University of Innsbruck, Austria
1996-1998 MD thesis, Institute of Pathophysiology, Innsbruck, Austria
Jan 1999 Medical degree with distinction
“sub auspiciis presidentis rei publicae”
2001-2004 PhD thesis, University of London, United Kingdom

 

Present Appointment


2011- Professor of Cardiovascular Proteomics
Cardiovascular Division, King’s College London,
London, UK

 

Previous Appointment


1999-2001 Postdoctoral scientist
Institute for Biomedical Aging Research,
Austrian Academy of Sciences,
Innsbruck, Austria
2001-2004 Research fellow
Cardiac and Vascular Sciences,
St George’s Hospital Medical School, London, UK
2005-2006 Lecturer
Dept. of Cardiac and Vascular Sciences,
St George’s Hospital Medical School, London, UK
2006-2010 Senior Lecturer
Cardiovascular Division, King’s College London,
London, UK
2010-2011 Reader in Cardiovascular Proteomics
Cardiovascular Division, King’s College London,
London, UK

 

Awards & Prizes

Awards & Prizes


1993-1998 Scholarships of the University of Innsbruck
1996 Scholarship of the “Hans und Blanca Moser Stiftung”
1996 Travel grant of the Austrian Chemical Industry
1997 Scholarship of the Rotary Club Innsbruck
1997 Poster prize, Annual Meeting of the Austrian Society for Clinical Chemistry
1997 Best oral presentation in Cardiology, 8th European Students’ Conference
1998 Erwin Wenzel Prize of Upper Austria
1999 Prize of the Austrian Society for Allergology and Immunology
1999 Award of the Austrian Federal Minister for Science
2000 Merck, Sharp & Dohme Prize of the Austrian Atherosclerosis Society
2000 3rd Prize Update in Thrombolysis
2000 European Vascular Biology Fellowship
2002 Young Investigator Award, British Atherosclerosis Society
2005 Intermediate Fellowship, British Heart Foundation
2007 Michael Davies Early Career Award,
British Cardiovascular Society
2009 Finalist for the American Heart Association’s Functional Genomics and Translational Biology Young Investigator Award
2010 Finalist for the Irvine H. Page Young Investigator Research Award, American Heart Association, Council on Arteriosclerosis, Thrombosis and Vascular Biology
2010 John French Lecturer, British Atherosclerosis Society
2010 The Bernard and Joan Marshall Research Excellence Prize
2013 European Society of Cardiology Outstanding Achievement Award

 

Publications


1 Sangiao-Alvarellos S, Theofilatos K, Barwari T, Gutmann C, Takov K, Singh B, Juiz-Valia P, Varela-Rodrguez BM, Outeirio-Blanco E, Duregotti E, Zampetaki A, Lunger L, Ebenbichler C, Tilg H, Garca-Brao MJ, Willeit P, Mena E, Kiechl S, Cordido F, Mayr M. Metabolic recovery after weight loss surgery is reflected in serum microRNAs. BMJ Open Diabetes Research and Care. 2020 8(2) : e001441. [Full Text] [PubMed] [DOI]

2 Gutmann C, Takov K, Burnap S, Singh B, Theofilatos K, Reed E, Hasman M, Nabeebaccus A, Fish M, McPhail M, O'Gallagher K, Schmidt L, Cassel C, Rienks M, Yin X, Auzinger G, Napoli S, Mujib S, Trovato F, Sanderson B, Merrick B, Niazi U, Saqi M, Dimitrakopoulou K, Braun S, Kronstein-Wiedemann R, Doores K, Edgeworth J, Shah A, Bornstein S, Tonn T, Hayday A, Shankar-Hari M, Mayr M. SARS-CoV-2 RNAemia and proteomic biomarker trajectory inform prognostication in COVID-19 patients admitted to intensive care. . 2020 : . [Full Text] [DOI]

3 Mayer L, Pechlaner R, Barallobre-Barreiro J, Boehme C, Toell T, Lynch M, Yin X, Willeit J, Gizewski ER, Perco P, Ratzinger G, Kiechl S, Mayr M, Knoflach M. Extracellular matrix protein signature of recurrent spontaneous cervical artery dissection. Neurology. 2020 95(15) : e2047-55. [Full Text] [PubMed] [DOI]

4 Tocchetti CG, Ameri P, de Boer RA, DAlessandra Y, Russo M, Sorriento D, Ciccarelli M, Kiss B, Bertrand L, Dawson D, Falcao-Pires I, Giacca M, Hamdani N, Linke WA, Mayr M, van der Velden J, Zacchigna S, Ghigo A, Hirsch E, Lyon AR, Grbe A, Ferdinandy P, Madonna R, Heymans S, Thum T. Cardiac dysfunction in cancer patients: beyond direct cardiomyocyte damage of anticancer drugs: novel cardio-oncology insights from the joint 2019 meeting of the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart. Cardiovascular Research. 2020 116(11) : 18201834. [Full Text] [PubMed] [DOI]

5 Brayson D, Holohan SJ, Bardswell SC, Arno M, Lu H, Jensen HK, Tran PK, Barallobre?Barreiro J, Mayr M, Dos Remedios CG, Tsang VT, Frigiola A, Kentish JC. Right Ventricle Has Normal Myofilament Function But Shows Perturbations in the Expression of Extracellular Matrix Genes in Patients With Tetralogy of Fallot Undergoing Pulmonary Valve Replacement. Journal of the American Heart Association. 2020 9(16) : e015342. [Full Text] [PubMed] [DOI]

6 Hohl M, Mayr M, Lang L, Nickel AG, Barallobre-Barreiro J, Yin X, Speer T, Selejan SR, Goettsch C, Erb K, Fecher-Trost C, Reil JC, Linz B, Ruf S, Hbschle T, Maak C, Bhm M, Sadowski T, Linz D. Cathepsin A contributes to left ventricular remodeling by degrading extracellular superoxide dismutase in mice. Journal of Biological Chemistry. 2020 295(36) : 12605-12617. [Full Text] [PubMed] [DOI]

7 Dittrich GM, Froese N, Wang X, Kroeger H, Wang H, Szaroszyk M, Malek-Mohammadi M, Cordero J, Keles M, Korf-Klingebiel M, Wollert KC, Geffers R, Mayr M, Conway S, Dobreva G, Bauersachs J, Heineke J. Fibroblast GATA-4 and GATA-6 promote myocardial adaptation to pressure overload by enhancing cardiac angiogenesis. Basic Research in Cardiology. 2021 116(1) : 1-19. [Full Text] [PubMed] [DOI]

8 Price NL, Zhang X, Fernndez-Tussy P, Singh AK, Burnap SA, Rotllan N, Goedeke L, Sun J, Canfrn-Duque A, Aryal B, Mayr M. Loss of hepatic miR-33 improves metabolic homeostasis and liver function without altering body weight or atherosclerosis. Proceedings of the National Academy of Sciences. 2021 118(5) : . [Full Text] [PubMed] [DOI]

9 Burnap SA, Mayr M. Lipoprotein compartmentalisation as a regulator of PCSK9 activity. Journal of Molecular and Cellular Cardiology. 2021 : . [Full Text] [PubMed] [DOI]

10 Burnap SA, Mayr U, Shankar-Hari M, Cuello F, Thomas MR, Shah AM, Sabroe I, Storey RF, Mayr M. A proteomics-based assessment of inflammation signatures in endotoxemia. Molecular & Cellular Proteomics. 2021 20 : 100021. [Full Text] [PubMed] [DOI]

11 Pechlaner R, Posod A, Yin X, Burnap SA, Kiechl SJ, Mayr M, Kiechl S, Kiechl-Kohlendorfer U. Very preterm birth results in later lower platelet activation markers. Pediatric Research. 2020 : 1-5. [Full Text] [PubMed] [DOI]

12 Schulte C, Barwari T, Joshi A, Zeller T, Mayr M.. Noncoding RNAs versus protein biomarkers in cardiovascular disease. Trends in Molecular Medicine. 2020 26(6) : 583-596. [Full Text] [PubMed] [DOI]

13 Gutmann C, Joshi A, Mayr M. Platelet "-omics" in health and cardiovascular disease. Atherosclerosis. 2020 : . [Full Text] [PubMed] [DOI]

14 Chan MV, Chen MH, Barwari T, Huffman JE, Armstrong PC, Hwang SJ, Santer P, Wierer B, Mayr M, Kiechl S, Johnson AD, Willeit J, Warner TD. Platelet Reactivity in Individuals Over 65 Years Old Is not Modulated by Age. Circ Res. 2020 : . [Full Text] [PubMed] [DOI]

15 Gutmann C, Joshi A, Zampetaki A, Mayr M. The Landscape of Coding and Non-coding RNAs in Platelets. Antioxidants & Redox Signaling. 2020 : . [Full Text] [DOI]

16 Krammer TL, Mayr M, Hackl M. . microRNAs as promising biomarkers of platelet activity in antiplatelet therapy monitoring.. Int J Mol Sci. 2020 21(10) : E3477. [Full Text] [PubMed] [DOI]

17 Parker WAE, Schulte C, Barwari T, Phoenix F, Pearson SM, Mayr M, Grant PJ, Storey RF, Ajjan RA. Aspirin, clopidogrel and prasugrel monotherapy in patients with type 2 diabetes mellitus: a double-blind randomised controlled trial of the effects on thrombotic markers and microRNA levels.. Cardiovasc Diabetol. 2020 19(1) : 3. [Full Text] [PubMed] [DOI]

18 Capoulade R, Torzewski M, Mayr M, Chan KL, Mathieu P, Boss Y, Dumesnil JG, Tam J, Teo KK, Burnap SA, Schmid J, Gobel N, Franke UFW, Sanchez A, Witztum JL, Yang X, Yeang C, Arsenault B, Desprs JP, Pibarot P, Tsimikas S.. ApoCIII-Lp(a) complexes in conjunction with Lp(a)-OxPL predict rapid progression of aortic stenosis.. Heart. 2020 106(10) : 738-745. [Full Text] [PubMed] [DOI]

19 Foinquinos A, Batkai S, Genschel C, Viereck J, Rump S, Gyngysi M, Traxler D, Riesenhuber M, Spannbauer A, Lukovic D, Weber N, Zlabinger K, Haimbegovi? E, Winkler J, Fiedler J, Dangwal S, Fischer M, de la Roche J, Wojciechowski D, Kraft T, Garamvlgyi R, Neitzel S, Chatterjee S, Yin X, Br C, Mayr M, Xiao K, Thum T. Preclinical development of a miR-132 inhibitor for heart failure treatment.. Nat Commun. 2020 11(1) : 633. [Full Text] [PubMed] [DOI]

20 Yang X, Yang W, McVey DG, Zhao G, Hu J, Poston RN, Ren M, Willeit K, Coassin S, Willeit J, Webb TR, Samani NJ, Mayr M, Kiechl S, Ye S . FURIN Expression in Vascular Endothelial Cells Is Modulated by a Coronary Artery Disease-Associated Genetic Variant and Influences Monocyte Transendothelial Migration. J Am Heart Assoc. 2020 9(4) : e014333. [Full Text] [PubMed] [DOI]

21 Corral-Acero J, Margara F, Marciniak M, Rodero C, Loncaric F, Feng Y, Gilbert A, Fernandes JF, Bukhari HA, Wajdan A, Martinez MV, Santos MS, Shamohammdi M, Luo H, Westphal P, Leeson P, DiAchille P, Gurev V, Mayr M, Geris L, Pathmanathan P, Morrison T, Cornelussen R, Prinzen F, Delhaas T, Doltra A, Sitges M, Vigmond EJ, Zacur E, Grau V, Rodriguez B, Remme EW, Niederer S, Mortier P, McLeod K, Potse M, Pueyo E, Bueno-Orovio A, Lamata P . The 'Digital Twin' to enable the vision of precision cardiology.. Eur Heart J. 2020 4 : ehaa159. [Full Text] [PubMed] [DOI]

22 Magadum A, Singh N, Kurian AA, Munir I, Mehmood T, Brown K, Sharkar MTK, Chepurko E, Sassi Y, Oh JG, Lee P, Santos CXC, Gaziel-Sovran A, Zhang G, Cai CL, Kho C, Mayr M, Shah AM, Hajjar RJ, Zangi L. . Pkm2 Regulates Cardiomyocyte Cell Cycle and Promotes Cardiac Regeneration. Circulation. 2020 141(15) : 1249-1265. [Full Text] [PubMed] [DOI]

23 Burnap SA, Joshi A, Tsimikas S, Fernndez-Hernando C, Kiechl S, Berry SE, Hall W, Levkau B, Mayr M. High-Density Lipoproteins Are the Main Carriers of PCSK9 in the Circulation. J Am Coll Cardiol. 2020 75(12) : 1495-1497. [Full Text] [PubMed] [DOI]

24 Braza-Bols A, Barwari T, Gutmann C, Thomas MR, Judge HM, Joshi A, Pechlaner R, Shankar-Hari M, Ajjan RA, Sabroe I, Storey RF, Mayr M. Circulating MicroRNA Levels Indicate Platelet and Leukocyte Activation in Endotoxemia Despite Platelet P2Y12 Inhibition. Int J Mol Sci. 2020 21(8) : 2897. [Full Text] [PubMed] [DOI]

25 Chan MV, Chen MH, Barwari T, Huffman JE, Armstrong PC, Hwang SJ, Santer P, Wierer B, Mayr M, Kiechl S, Johnson AD, Willeit J, Warner TD. Platelet Reactivity in Individuals Over 65 Years Old Is not Modulated by Age. Circ Res. 2020 : . [Full Text] [PubMed] [DOI]

26 Barallobre-Barreiro J, Loeys B, Mayr M, Rienks M, Verstraeten A, Kovacic JC. Extracellular Matrix in Vascular Disease, Part 2/4 JACC Focus Seminar. J Am Coll Cardiol. 2020 5, 75(17) : 2189-2203. [Full Text] [PubMed] [DOI]

27 Zacchigna S, Paldino A, Falco-Pires I, Daskalopoulos EP, Dal Ferro M, Vodret S, Lesizza P, Cannat A, Miranda-Silva D, Loureno AP, Pinamonti B, Sinagra G, Weinberger F, Eschenhagen T, Carrier L, Kehat I, Tocchetti CG, Russo M, Ghigo A, Cimino J, Hirsch E, Dawson D, Ciccarelli M, Oliveti M, Linke WA, Cuijpers I, Heymans S, Hamdani N, de Boer M, Duncker D, Kuster D, van der Velden J, Beauloye C, Bertrand L, Mayr M, Giacca M, Leuschner F, Backs J, Thum T. Toward standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function.. Cardiovasc Res. 2020 4 : cvaa110. [Full Text] [PubMed] [DOI]

28 Trautsch I, Heta E, Soong PL, Levent E, Nikolaev VO, Bogeski I, Katschinski DM, Mayr M, Zimmermann WH.. Optogenetic Monitoring of the Glutathione Redox State in Engineered Human Myocardium.. Front Physiol.. 2019 10 : 272. [Full Text] [PubMed] [DOI]

29 Yin X, Wanga S, Fellows AL, Barallobre-Barreiro J, Lu R, Davaapil H, Franken R, Fava M, Baig F, Skroblin P, Xing Q, Koolbergen DR, Groenink M, Zwinderman AH, Balm R, de Vries CJM, Mulder BJM, Viner R, Jahangiri M, Reinhardt DP, Sinha S, de Waard V, Mayr M.. Glycoproteomic Analysis of the Aortic Extracellular Matrix in Marfan Patients.. Arterioscler Thromb Vasc Biol.. 2019 39(9) : 1859-1873. [Full Text] [PubMed] [DOI]

30 Olin JW, Di Narzo AF, d'Escamard V, Kadian-Dodov D, Cheng H, Georges A, King A, Thomas A, Barwari T, Michelis KC, Bouchareb R, Bander E, Anyanwu A, Stelzer P, Filsoufi F, Florman S, Civelek M, Debette S, Jeunemaitre X, Bjorkegren JLM, Mayr M, Bouatia-Naji N, Hao K, Kovacic JC.. A plasma proteogenomic signature for fibromuscular dysplasia.. Cardiovasc Res.. 2020 116(1) : 63-77. [Full Text] [PubMed] [DOI]

31 Grund A, Szaroszyk M, Korf-Klingebiel M, Malek Mohammadi M, Trogisch FA, Schrameck U, Gigina A, Tiedje C, Gaestel M, Kraft T, Hegermann J, Batkai S, Thum T, Perrot A, Remedios CD, Riechert E, Vlkers M, Doroudgar S, Jungmann A, Bauer R, Yin X, Mayr M, Wollert KC, Pich A, Xiao H, Katus HA, Bauersachs J, Mller OJ, Heineke J.. TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation.. EMBO Mol Med.. 2019 11(10) : e10018. [Full Text] [PubMed] [DOI]

32 Schulte C, Joshi A, Mayr M.. Response by Schulte et al to Letter Regarding Article, Comparative Analysis of Circulating Noncoding RNAs Versus Protein Biomarkers in the Detection of Myocardial Injury. Circ Res.. 2019 125(4) : e22-e23. [Full Text] [PubMed] [DOI]

33 Stojkovic S, Koller L, Sulzgruber P, Hlsmann M, Huber K, Mayr M, Hengstenberg C, Wojta J, Niessner A.. Liver-specific microRNA-122 as prognostic biomarker in patients with chronic systolic heart failure. . Int J Cardiol.. 2020 19 : 33664-2. [Full Text] [PubMed] [DOI]

34 Posod A, Pechlaner R, Yin X, Burnap SA, Kiechl SJ, Willeit J, Witztum JL, Mayr M, Kiechl S, Kiechl-Kohlendorfer U. Apolipoprotein Profiles in Very Preterm and Term-Born Preschool Children. J Am Heart Assoc. 2019 8 : e011199. [Full Text] [PubMed] [DOI]

35 Forte A, Yin X, Fava M, Bancone C, Cipollaro M, De Feo M, Mayr M, Jahangiri M, Della Corte A. Locally different proteome in aortas from patients with stenotic tricuspid and bicuspid aortic valves. Eur J Cardiothorac Surg. 2019 Epub : ahead of print. [Full Text] [PubMed] [DOI]

36 de Boer RA, De Keulenaer G, Bauersachs J, Brutsaert D, Cleland JG, Diez J, Du XJ, Ford P, Heinzel FR, Lipson KE, McDonagh T, Lopez-Andres N, Lunde IG, Lyon AR, Pollesello P, Prasad SK, Tocchetti CG, Mayr M, Sluijter JPG, Thum T, Tschöpe C, Zannad F, Zimmermann WH, Ruschitzka F, Filippatos G, Lindsey ML, Maack C, Heymans S. Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology. Eur J Heart Fail. 2019 Epub : ahead of print. [Full Text] [PubMed] [DOI]

37 Schulte C, Mayr M. MicroRNAs: A New Understanding of Platelet Physiology and Pathology. Thromb Haemost. 2019 119 : 191. [Full Text] [PubMed] [DOI]

38 Rienks M, Barallobre-Barreiro J, Mayr M. The Emerging Role of the ADAMTS Family in Vascular Diseases. Circ Res. 2018 123 : 1279-1281. [Full Text] [PubMed] [DOI]

39 Joshi A, Mayr M. In Aptamers They Trust: The Caveats of the SOMAscan Biomarker Discovery Platform from SomaLogic. Circulation. 2018 138 : 2482-2485. [Full Text] [PubMed] [DOI]

40 Barwari T, Eminaga S, Mayr U, Lu R, Armstrong PC, Chan MV, Sahraei M, Fernández-Fuertes M, Moreau T, Barallobre-Barreiro J, Lynch M, Yin X, Schulte C, Baig F, Pechlaner R, Langley SR, Zampetaki A, Santer P, Weger M, Plasenzotti R, Schosserer M, Grillari J, Kiechl S, Willeit J, Shah AM, Ghevaert C, Warner TD, Fernández-Hernando C, Suárez Y, Mayr M. Inhibition of profibrotic microRNA-21 affects platelets and their releasate. JCI Insight. 2018 3 : e123335. [Full Text] [PubMed] [DOI]

41 McAloon CJ, Barwari T, Hu J, Hamborg T, Nevill A, Hyndman S, Ansell V, Musa A, Jones J, Goodby J, Banerjee P, O'Hare P, Mayr M, Randeva H, Osman F. Characterisation of circulating biomarkers before and after cardiac resynchronisation therapy and their role in predicting CRT response: the COVERT-HF study. Open Heart. 2018 5 : e000899. [Full Text] [PubMed] [DOI]

42 Rienks M, Joshi A, Mayr M. MicroRNA-24 and the Diabetic Heart. JACC: Basic to Translational Science. 2018 3 : 363-365. [Full Text] [PubMed] [DOI]

43 Kiechl S, Pechlaner R, Willeit P, Notdurfter M, Paulweber B, Willeit K, Werner P, Ruckenstuhl C, Iglseder B, Weger S, Mairhofer B, Gartner M, Kedenko L, Chmelikova M, Stekovic S, Stuppner H, Oberhollenzer F, Kroemer G, Mayr M, Eisenberg T, Tilg H, Madeo F, Willeit J. Higher spermidine intake is linked to lower mortality: a prospective population-based study. Am J Clin Nutr. 2018 108 : 371-380. [Full Text] [PubMed] [DOI]

44 Burnap SA, Mayr M. Extracellular Vesicle Crosstalk Between the Myocardium and Immune System Upon Infarction. Circ Res. 2018 123 : 15-17. [Full Text] [PubMed] [DOI]

45 van der Velden J, Gabriele Tocchetti C, Varricchi G, Bianco A, Sequeira V, Hilfiker-Kleiner D, Hamdani N, Leite-Moreira A, Mayr M, Falcao-Pires I, Thum T, Dawson DK, Balligand JL, Heymans S. Metabolic changes in hypertrophic cardiomyopathies: Scientific update from the Working Group of Myocardial Function of the European Society of Cardiology. Cardiovasc Res. 2018 114 : 1273-1280. [Full Text] [PubMed] [DOI]

46 Huntley RP, Kramarz B, Sawford T, Umrao Z, Kalea AZ, Acquaah V, Martin MJ, Mayr M, Lovering RC. Expanding the horizons of microRNA bioinformatics. RNA. 2018 24 : 1005-1017. [Full Text] [PubMed] [DOI]

47 Fiedler J, Baker AH, Dimmeler S, Heymans S, Mayr M, Thum T. Non coding RNAs in vascular disease - from basic science to clinical applications: Scientific update from the Working Group of Myocardial Function of the European Society of Cardiology. Cardiovascu Res. 2018 114 : 1281-1286. [Full Text] [PubMed] [DOI]

48 Fava M, Barallobre-Barreiro J, Mayr U, Lu R, Didangelos A, Baig F, Lynch M, Catibog N, Joshi A, Barwari T, Yin X, Jahangiri M, Mayr M. Role of ADAMTS (A Disintegrin and Metalloproteinase With Thrombospondin Motifs)-5 in Aortic Dilatation and Extracellular Matrix Remodeling. Arterioscler Thromb Vasc Biol. 2018 38 : 1537-1548. [Full Text] [PubMed] [DOI]

49 Barwari T, Rienks M, Mayr M. MicroRNA-21 and the Vulnerability of Atherosclerotic Plaques. Mol Ther. 2018 26 : 938-940. [Full Text] [PubMed] [DOI]

50 Uderhardt S, Ackermann JA, Fillep T, Hammond VJ, Willeit J, Santer P, Mayr M, Biburger M, Miller M, Zellner KR, Stark K, Zarbock A, Rossaint J, Schubert I, Mielenz D, Dietel B, Raaz-Schrauder D, Ay C, Gremmel T, Thaler J, Heim C, Herrmann M, Collins PW, Schabbauer G, Mackman N, Voehringer D, Nadler JL, Lee JJ, Massberg S, Rauh M, Kiechl S, Schett G, O'Donnell VB, Krnke G. Correction: Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease. J Exp Med. 2018 215 : 1003. [Full Text] [PubMed] [DOI]

51 Mayr M, Gerszten R, Kiechl S. Cardiovascular Risk Beyond Low-Density Lipoprotein Cholesterol. J Am Coll Cardiol. 2018 13 : 633-635. [Full Text] [PubMed] [DOI]

52 Frantz S, Falcao-Pires I, Balligand JL, Bauersachs J, Brutsaert D, Ciccarelli M, Dawson D, de Windt LJ, Giacca M, Hamdani N, Hilfiker-Kleiner D, Hirsch E, Leite-Moreira A, Mayr M, Thum T, Tocchetti CG, van der Velden J, Varricchi G, Heymans S. The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC.. Eur J Heart Fail. 2018 3 : 445-459. [Full Text] [PubMed] [DOI]

53 Nabeebaccus AA, Zoccarato A, Hafstad AD, Santos CX, Aasum E, Brewer AC, Zhang M, Beretta M, Yin X, West JA, Schröder K, Griffin JL, Eykyn TR, Abel ED, Mayr M, Shah AM. Nox4 reprograms cardiac substrate metabolism via protein O-GlcNAcylation to enhance stress adaptation. JCI Insight. 2017 2 : e96184. [Full Text] [PubMed] [DOI]

54 Yin X, Baig F, Haudebourg E, Blankley RT, Gandhi T, Müller S, Reiter L, Hinterwirth H, Pechlaner R, Tsimikas S, Santer P, Willeit J, Kiechl S, Witztum JL, Sullivan A, Mayr M. Plasma Proteomics for Epidemiology: Increasing Throughput With Standard-Flow Rates. Circ Cardiovasc Genet. 2017 10 : e001808. [Full Text] [PubMed] [DOI]

55 Child N, Suna G, Dabir D, Yap ML, Rogers T, Kathirgamanathan M, Arroyo-Ucar E, Hinojar R, Mahmoud I, Young C, Wendler O, Mayr M, Sandhu B, Morton G, Muhly-Reinholz M, Dimmeler S, Nagel E, Puntmann VO. Comparison of MOLLI, shMOLLLI, and SASHA in discrimination between health and disease and relationship with histologically derived collagen volume fraction. Eur Heart J Cardiovasc Imaging. 2017 19 : 768-776. [Full Text] [PubMed] [DOI]

56 Sassi Y, Avramopoulos P, Ramanujam D, Grüter L, Werfel S, Giosele S, Brunner AD, Esfandyari D, Papadopoulou AS, De Strooper B, Hübner N, Kumarswamy R, Thum T, Yin X, Mayr M, Laggerbauer B, Engelhardt S. Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling. Nat Commun. 2017 8 : 1614. [Full Text] [PubMed] [DOI]

57 Lourenço AP, Leite-Moreira AF, Balligand JL, Bauersachs J, Dawson D, de Boer RA, de Windt LJ, Falcão-Pires I, Fontes-Carvalho R, Franz S, Giacca M, Hilfiker-Kleiner D, Hirsch E, Maack C, Mayr M, Pieske B, Thum T, Tocchetti CG, Brutsaert DL, Heymans S. An integrative translational approach to study heart failure with preserved ejection fraction: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology. Eur J Heart Fail. 2017 Epub : ahead of print. [Full Text] [PubMed] [DOI]

58 Hermida N, Michel L, Esfahani H, Dubois-Deruy E, Hammond J, Bouzin C, Markl A, Colin H, Steenbergen AV, De Meester C, Beauloye C, Horman S, Yin X, Mayr M, Balligand JL. Cardiac myocyte β3-adrenergic receptors prevent myocardial fibrosis by modulating oxidant stress-dependent paracrine signaling. Eur Heart J. 2018 39 : 888-898. [Full Text] [PubMed] [DOI]

59 Price NL, Rotllan N, Canfrán-Duque A, Zhang X, Pati P, Arias N, Moen J, Mayr M, Ford DA, Baldán Á, Suárez Y, Fernández-Hernando C. Genetic Dissection of the Impact of miR-33a and miR-33b during the Progression of Atherosclerosis. Cell Rep. 2017 21 : 1317-1330. [Full Text] [PubMed] [DOI]

60 Suna G, Wojakowski W, Lynch M, Barallobre-Barreiro J, Yin X, Mayr U, Baig F, Lu R, Fava M, Hayward R, Molenaar C, White SJ, Roleder T, Milewski K, Gasior P, Buszman PP, Buszman PE, Jahangiri M, Shanahan C, Hill JM, Mayr M. Extracellular Matrix Proteomics Reveals Interplay of Aggrecan and Aggrecanases in Vascular Remodeling of Stented Coronary Arteries. Circulation. 2018 137 : 166-183. [Full Text] [PubMed] [DOI]

61 Lataniotis L, Albrecht A, Kok FO, Monfries CAL, Benedetti L, Lawson ND, Hughes SM, Steinhofel K, Mayr M, Zampetaki A. CRISPR/Cas9 editing reveals novel mechanisms of clustered microRNA regulation and function. Sci Rep. 2017 7 : 8585. [Full Text] [PubMed] [DOI]

62 Paschalaki KE, Zampetaki A, Baker JR, Birrell MA, Starke RD, Belvisi MG, Donnelly LE, Mayr M, Randi AM, Barnes PJ. Downregulation of MicroRNA-126 Augments DNA Damage Response in Cigarette Smokers and COPD Patients. Am J Respir Crit Care Med. 2017 197 : 665-668. [Full Text] [PubMed] [DOI]

63 Baig F, Mayr M. What are the prospects of apolipoprotein profiling for cardiovascular disease?. Expert Rev Mol Diagn. 2017 Epub : ahead of print. [Full Text] [PubMed] [DOI]

64 Zampetaki A, Mayr M. Long Noncoding RNAs and Angiogenesis: Regulatory Information for Chromatin Remodeling. Circulation. 2017 136 : 80-82. [Full Text] [PubMed] [DOI]

65 Viviano A, Yin X, Zampetaki A, Fava M, Gallagher M, Mayr M, Jahangiri M. Proteomics of the epicardial fat secretome and its role in post-operative atrial fibrillation. Europace. 2017 20 : 1201-1208. [Full Text] [PubMed] [DOI]

66 Uderhardt S, Ackermann JA, Fillep T, Hammond VJ, Willeit J, Santer P, Mayr M, Biburger M, Miller M, Zellner KR, Stark K, Zarbock A, Rossaint J, Schubert I, Mielenz D, Dietel B, Raaz-Schrauder D, Ay C, Gremmel T, Thaler J, Heim C, Herrmann M, Collins PW, Schabbauer G, Mackman N, Voehringer D, Nadler JL, Lee JJ, Massberg S, Rauh M, Kiechl S, Schett G, O'Donnell VB, Krönke G. Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease. J Exp Med. 2017 214 : 2121-2138. [Full Text] [PubMed] [DOI]

67 Barallobre-Barreiro J, Baig F, Fava M, Yin X, Mayr M. Glycoproteomics of the Extracellular Matrix: A Method for Intact Glycopeptide Analysis Using Mass Spectrometry. J Vis Exp. 2017 122 : . [Full Text] [PubMed] [DOI]

68 Perrino C, Barabási AL, Condorelli G, Davidson SM, De Windt L, Dimmeler S, Engel FB, Hausenloy DJ, Hill JA, Van Laake LW, Lecour S, Leor J, Madonna R, Mayr M, Prunier F, Sluijter JPG, Schulz R, Thum T, Ytrehus K, Ferdinandy P. Epigenomic and transcriptomic approaches in the post-genomic era: path to novel targets for diagnosis and therapy of the ischaemic heart? Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart. Cardiovasc Res. 2017 7 : 725-736. [Full Text] [PubMed] [DOI]

69 Boengler K, Kosiol M, Mayr M, Schulz R, Rohrbach S. Mitochondria and ageing: role in heart, skeletal muscle and adipose tissue. J Cachexia Sarcopenia Muscle. 2017 8 : 349-369. [Full Text] [PubMed] [DOI]

70 Barwari T, Joshi A, Mayr M. Reply: The Complex miRNAs-p53 Signaling Network in Cardiovascular Disease. J Am Coll Cardiol. 2017 16 : 2100. [Full Text] [PubMed] [DOI]

71 Willeit K, Pechlaner R, Willeit P, Skroblin P, Paulweber B, Schernthaner C, Toell T, Egger G, Weger S, Oberhollenzer M, Kedenko L, Iglseder B, Bonora E, Schett G, Mayr M, Willeit J, Kiechl S. Association Between Vascular Cell Adhesion Molecule 1 and Atrial Fibrillation. JAMA Cardiol. 2017 5 : 516-523. [PubMed] [DOI]

72 Langley SR, Willeit K, Didangelos A, Matic LP, Skroblin P, Barallobre-Barreiro J, Lengquist M, Rungger G, Kapustin A, Kedenko L, Molenaar C, Lu R, Barwari T, Suna G, Yin X, Iglseder B, Paulweber B, Willeit P, Shalhoub J, Pasterkamp G, Davies AH, Monaco C, Hedin U, Shanahan CM, Willeit J, Kiechl S, Mayr M. Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques. J Clin Invest. 2017 4 : 1546-1560. [Full Text] [PubMed] [DOI]

73 Pechlaner R, Tsimikas S, Yin X, Willeit P, Baig F, Santer P, Oberhollenzer F, Egger G, Witztum JL, Alexander VJ, Willeit J, Kiechl S, Mayr M. Very-Low-Density Lipoprotein-Associated Apolipoproteins Predict Cardiovascular Events and Are Lowered by Inhibition of APOC-III. J Am Coll Cardiol. 2017 69 : 789-800. [Full Text] [PubMed] [DOI]

74 Sunderland N, Skroblin P, Barwari T, Huntley RP, Lu R, Joshi A, Lovering RC, Mayr M. MicroRNA Biomarkers and Platelet Reactivity: The Clot Thickens. Circ Res. 2017 20 : 418-435. [Full Text] [PubMed] [DOI]

75 Hinkel R, Howe A, Renner S, Ng J, Lee S, Klett K, Kaczmarek V, Moretti A, Laugwitz KL, Skroblin P, Mayr M, Milting H, Dendorfer A, Reichart B, Wolf E, Kupatt C. Diabetes Mellitus-Induced Microvascular Destabilization in the Myocardium. J Am Coll Cardiol. 2017 69 : 131-143. [Full Text] [PubMed] [DOI]

76 Baig F, Joshi A, Mayr M. High Density Lipoproteins in High Resolution: Will Proteomics Solve the Paradox for Cardiovascular Risk?. Proteomics. 2017 17 : 3-4. [Full Text] [PubMed] [DOI]

77 Khan SY, Awad EM, Oszwald A, Mayr M, Yin X, Waltenberger B, Stuppner H, Lipovac M, Uhrin P, Breuss JM. Premature senescence of endothelial cells upon chronic exposure to TNFα can be prevented by N-acetyl cysteine and plumericin. Sci Rep. 2017 7 : 39501. [Full Text] [PubMed] [DOI]

78 Barwari T, Joshi A, Mayr M . MicroRNAs in Cardiovascular Disease. J Am Coll Cardiol. 2016 13 : 2577-2584. [Full Text] [PubMed] [DOI]

79 Willeit P, Skroblin P, Moschen AR, Yin X, Kaudewitz D, Zampetaki A, Barwari T, Whitehead M, Ramírez CM, Goedeke L, Rotllan N, Bonora E, Hughes AD, Santer P, Fernández-Hernando C, Tilg H, Willeit J, Kiechl S, Mayr M.. Circulating MicroRNA-122 Is Associated With the Risk of New-Onset Metabolic Syndrome and Type 2 Diabetes. Diabetes. 2017 66 : 347-357. [Full Text] [PubMed] [DOI]

80 Pechlaner R, Kiechl S, Mayr M. Potential and Caveats of Lipidomics for Cardiovascular Disease. Circulation. 2016 134 : 1651-1654. [Full Text] [PubMed] [DOI]

81 Cabrera-Fuentes HA, Aragones J, Bernhagen J, Boening A, Boisvert WA, Bøtker HE, Bulluck H, Cook S, Di Lisa F, Engel FB, Engelmann B, Ferrazzi F, Ferdinandy P, Fong A, Fleming I, Gnaiger E, Hernández-Reséndiz S, Kalkhoran SB, Kim MH, Lecour S, Liehn EA, Marber MS, Mayr M, Miura T, Ong SB, Peter K, Sedding D, Singh MK, Suleiman MS, Schnittler HJ, Schulz R, Shim W, Tello D6, Vogel CW, Walker M, Li Q, Yellon DM, Hausenloy DJ, Preissner KT. From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on "New frontiers in cardiovascular research. Basic Res Cardiol. 2016 111 : 69. [Full Text] [PubMed] [DOI]

82 Barallobre-Barreiro J, Lynch M, Yin X, Mayr M. Systems Biology - Opportunities and Challenges: The Application of Proteomics to Study the Cardiovascular Extracellular Matrix. Cardiovasc Res. 2016 112 : 626-636. [Full Text] [PubMed] [DOI]

83 Baig F, Pechlaner R, Mayr M. Caveats of Untargeted Metabolomics for Biomarker Discovery. J Am Coll Cardiol. 2016 68 : 1294-1296. [Full Text] [PubMed] [DOI]

84 Barallobre-Barreiro J, Gupta SK, Zoccarato A, Kitazume-Taneike R, Fava M, Yin X, Werner T, Hirt MN, Zampetaki A, Viviano A, Chong M, Bern M, Kourliouros A, Domenech N, Willeit P, Shah AM, Jahangiri M, Schaefer L, Fischer JW, Iozzo RV, Viner R, Thum T, Heineke J, Kichler A, Otsu K, Mayr M. Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation. 2016 134 : 817-832. [Full Text] [PubMed] [DOI]

85 Hinojar R, Foote L, Sangle S, Marber M, Mayr M, Carr-White G, D'Cruz D, Nagel E, Puntmann VO. Native T1 and T2 mapping by CMR in lupus myocarditis: Disease recognition and response to treatment. Int J Cardiol. 2016 222 : 717-726. [Full Text] [PubMed] [DOI]

86 Bauer A, Mylroie H, Thornton CC, Calay D, Birdsey GM, Kiprianos AP, Wilson GK, Soares MP, Yin X, Mayr M, Randi AM, Mason JC. Identification of cyclins A1, E1 and vimentin as downstream targets of heme oxygenase-1 in vascular endothelial growth factor-mediated angiogenesis. Sci Rep. 2016 8 : 29417. [Full Text] [PubMed] [DOI]

87 Zervou S, Yin X, A Nabeebaccus A, O'Brien BA, L Cross R, McAndrew DJ, Atkinson RA, Eykyn TR, Mayr M, Neubauer S, Lygate CA. Proteomic and metabolomic changes driven by elevating myocardial creatine suggest novel metabolic feedback mechanisms. Amino Acids. 2016 48 : 1969-1981. [Full Text] [PubMed] [DOI]

88 Ulrich V, Rotllan N, Araldi E, Luciano A, Skroblin P, Abonnenc M, Perrotta P, Yin X, Bauer A, Leslie KL, Zhang P, Aryal B, Montgomery RL, Thum T, Martin K, Suarez Y, Mayr M, Fernandez-Hernando C, Sessa WC. Chronic miR-29 antagonism promotes favorable plaque remodeling in atherosclerotic mice. EMBO Mol Med. 2016 8 : 643-653. [Full Text] [PubMed] [DOI]

89 Willeit P, Skroblin P, Kiechl S, Fernández-Hernando C, Mayr M. Liver microRNAs: potential mediators and biomarkers for metabolic and cardiovascular disease?. Eur Heart J. 2016 14 : 3260-3266. [Full Text] [PubMed] [DOI]

90 Pereira NL, Geske JB, Mayr M, Shah SH, Rihal CS. Pharmacogenetics of Clopidogrel: An Unresolved Issue. Circ Cardiovasc Genet. 2016 9 : 185-188. [Full Text] [PubMed] [DOI]

91 Barallobre-Barreiro J, Oklu R, Lynch M, Fava M, Baig F, Yin X, Barwari T, Potier D, Albadawi H, Jahangiri M, Porter K, Watkins M, Misra S, Stoughton J, Mayr M. Extracellular Matrix Remodeling in Response to Venous Hypertension: Proteomics of Human Varicose Veins. Cardiovasc Res. 2016 110 : 419-430. [Full Text] [PubMed] [DOI]

92 Grandoch M, Kohlmorgen C, Melchior-Becker A, Feldmann K, Homann S, Müller J, Kiene LS, Zeng-Brouwers J, Schmitz F, Nagy N, Polzin A, Gowert NS, Elvers M, Skroblin P, Yin X, Mayr M, Schaefer L, Tannock LR, Fischer JW. Loss of Biglycan Enhances Thrombin Generation in Apolipoprotein E-Deficient Mice: Implications for Inflammation and Atherosclerosis. Arterioscler Thromb Vasc Biol. 2016 36 : 41-50. [Full Text] [PubMed] [DOI]

93 Fernandez-Caggiano M, Schröder E, Cho HJ, Burgoyne J, Barallobre-Barreiro J, Mayr M, Eaton P. Oxidant-induced interprotein disulfide formation in cardiac DJ-1 occurs via an interaction with peroxiredoxin 2. J Biol Chem. 2016 291 : 10399-10410. [Full Text] [PubMed] [DOI]

94 Lynch M, Barallobre-Barreiro J, Jahangiri M, Mayr M. Vascular proteomics in metabolic and cardiovascular diseases. J Intern Med. 2016 280 : 325-338. [Full Text] [PubMed] [DOI]

95 Huntley RP, Sitnikov D, Orlic-Milacic M, Balakrishnan R, D'Eustachio P, Gillespie ME, Howe D, Kalea AZ, Maegdefessel L, Osumi-Sutherland D, Petri V, Smith JR, Van Auken K, Wood V, Zampetaki A, Mayr M, Lovering RC. Guidelines for the functional annotation of microRNAs using the Gene Ontology. RNA. 2016 22 : 667-676. [Full Text] [PubMed] [DOI]

96 Barwari T, Skroblin P, Mayr M. When Sweet Turns Salty: Glucose-Induced Suppression of Atrial Natriuretic Peptide by MicroRNA-425. J Am Coll Cardiol. 2016 67 : 813-816. [Full Text] [PubMed] [DOI]

97 Gomes RS, Skroblin P, Munster AB, Tomlins H, Langley SR, Zampetaki A, Yin X, Wardle FC, Mayr M. "Young at heart": Regenerative potential linked to immature cardiac phenotypes. J Mol Cell Cardiol. 2016 92 : 105-108. [Full Text] [PubMed] [DOI]

98 Cabrera-Fuentes HA, Alba-Alba C, Aragones J, Bernhagen J, Boisvert WA, Bøtker HE, Cesarman-Maus G, Fleming I, Garcia-Dorado D, Lecour S, Liehn E, Marber MS, Marina N, Mayr M, Perez-Mendez O, Miura T, Ruiz-Meana M, Salinas-Estefanon EM, Ong SB, Schnittler HJ, Sanchez-Vega JT, Sumoza-Toledo A, Vogel CW, Yarullina D, Yellon DM, Preissner KT, Hausenloy DJ. Meeting report from the 2nd International Symposium on New Frontiers in Cardiovascular Research. Protecting the cardiovascular system from ischemia: between bench and bedside. Basic Res Cardiol. 2016 111 : Epub. [Full Text] [PubMed] [DOI]

99 Kaudewitz D, Skroblin P, Bender LH, Barwari T, Willeit P, Pechlaner R, Sunderland NP, Willeit K, Morton AC, Armstrong PC, Chan MV, Lu R, Yin X, Gracio F, Dudek K, Langley SR, Zampetaki A, de Rinaldis E, Ye S, Warner TD, Saxena A, Kiechl S, Storey RF, Mayr M. Association of MicroRNAs and YRNAs With Platelet Function. Circ Res. 2016 118 : 420-432. [Full Text] [PubMed] [DOI]

100 Kaudewitz D, Zampetaki A, Mayr M. MicroRNA Biomarkers for Coronary Artery Disease?. Curr Atheroscler Rep. 2015 17 : 70. [Full Text] [PubMed] [DOI]

101 Zampetaki A, Willeit P, Burr S, Yin X, Langley SR, Kiechl S, Klein R, Rossing P, Chaturvedi N, Mayr M. Angiogenic MicroRNAs Linked to Incidence and Progression of Diabetic Retinopathy in Type 1 Diabetes. Diabetes. 2016 65 : 216-227. [Full Text] [PubMed] [DOI]

102 Pechlaner R, Weiss G, Bansal S, Mayr M, Santer P, Pallhuber B, Notdurfter M, Bonora E, Willeit J, Kiechl S. Inadequate hepcidin serum concentrations predict incident type 2 diabetes mellitus. Diabetes Metab Res Rev. 2016 32 : 187-192. [Full Text] [PubMed] [DOI]

103 Zeng L, Li Y, Yang J, Wang G, Margariti A, Xiao Q, Zampetaki A, Yin X, Mayr M, Mori K, Wang W, Hu Y, Xu Q. XBP 1-Deficiency Abrogates Neointimal Lesion of Injured Vessels Via Cross Talk With the PDGF Signaling. Arterioscler Thromb Vasc Biol. 2015 35 : 2134-2144. [Full Text] [PubMed] [DOI]

104 Nabeebaccus A, Hafstad A, Eykyn T, Yin X, Brewer A, Zhang M, Mayr M, Shah A. Cardiac-targeted NADPH oxidase 4 in the adaptive cardiac remodelling of the murine heart. Lancet. 2015 385 Suppl1 : S73. [Full Text] [PubMed] [DOI]

105 Lindsey ML, Mayr M, Gomes AV, Delles C, Arrell DK, Murphy AM, Lange RA, Costello CE, Jin YF, Laskowitz DT, Sam F, Terzic A, Van Eyk J, Srinivas PR. Transformative Impact of Proteomics on Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association. Circulation. 2015 132 : 852-872. [Full Text] [PubMed] [DOI]

106 Langley SR, Mayr M. Comparative analysis of statistical methods used for detecting differential expression in label-free mass spectrometry proteomics. J Proteomics. 2015 129 : 83-92. [Full Text] [PubMed] [DOI]

107 Zampetaki A, Mayr M. Sweet Dicer: Impairment of Micro-RNA Processing by Diabetes. Circ Res. 2015 117 : 116-118. [Full Text] [PubMed] [DOI]

108 Pechlaner R, Kiechl S, Mayr M, Santer P, Weger S, Haschka D, Bansal SS, Willeit J, Weiss G. Correlates of serum hepcidin levels and its association with cardiovascular disease in an elderly general population. Clin Chem Lab Med. 2016 54 : 151-161. [Full Text] [PubMed] [DOI]

109 Hoefer IE, Steffens S, Ala-Korpela M, Bäck M, Badimon L, Bochaton-Piallat ML, Boulanger CM, Caligiuri G, Dimmeler S, Egido J, Evans PC, Guzik T, Kwak BR, Landmesser U, Mayr M, Monaco C, Pasterkamp G, Tuñón J, Weber C; ESC Working Group Atherosclerosis and Vascular Biology. Novel methodologies for biomarker discovery in atherosclerosis. Eur Heart J. 2015 36 : 2635-2642. [Full Text] [PubMed] [DOI]

110 Willeit P, Freitag DF, Laukkanen JA, Chowdhury S, Gobin R, Mayr M, Di Angelantonio E, Chowdhury R. Asymmetric dimethylarginine and cardiovascular risk: systematic review and meta-analysis of 22 prospective studies. J Am Heart Assoc. 2015 4 : e001833. [Full Text] [PubMed] [DOI]

111 Varga ZV, Giricz Z, Bencsik P, Madonna R, Gyöngyösi M, Schulz R, Mayr M, Thum T, Puskás LG, Ferdinandy P. Functional genomics of cardioprotection by ischemic conditioning and the influence of comorbid conditions: implications in target identification. Curr Drug Targets. 2015 16 : 904-911. [PubMed] [DOI]

112 Štalekar M, Yin X, Rebolj K, Darovic S, Troakes C, Mayr M, Shaw CE, Rogelj B. Proteomic analyses reveal that loss of TDP-43 affects RNA processing and intracellular transport. Neuroscience. 2015 7 : 157. [Full Text] [PubMed] [DOI]

113 Kessler T, Zhang L, Liu Z, Yin X, Huang Y, Wang Y, Fu Y, Mayr M, Ge Q, Xu Q, Zhu Y, Wang X, Schmidt K, de Wit C, Erdmann J, Schunkert H, Aherrahrou Z, Kong W. ADAMTS-7 Inhibits Re-endothelialization of Injured Arteries and Promotes Vascular Remodeling Through Cleavage of Thrombospondin-1. Circulation. 2015 131 : 1191-1201. [Full Text] [PubMed] [DOI]

114 Kapustin AN, Chatrou ML, Drozdov I, Zheng Y, Davidson SM, Soong D, Furmanik M, Sanchis P, De Rosales RT, Alvarez-Hernandez D, Shroff R, Yin X, Muller K, Skepper JN, Mayr M, Reutelingsperger CP, Chester A, Bertazzo S, Schurgers LJ, Shanahan CM. Vascular smooth muscle cell calcification is mediated by regulated exosome secretion. Circ Res. 2015 116 : 1312-1323. [Full Text] [PubMed] [DOI]

115 Barallobre-Barreiro J, Mayr M. Affinity proteomics for phosphatase interactions in atrial fibrillation. J Am Coll Cardiol. 2015 65 : 174-176. [Full Text] [PubMed] [DOI]

116 Hinterwirth H, Stegemann C, Mayr M. Lipidomics: quest for molecular lipid biomarkers in cardiovascular disease. Circ Cardiovasc Genet. 2014 7 : 941-954. [Full Text] [PubMed] [DOI]

117 Hinojar R, Foote L, Arroyo Ucar E, Jackson T, Jabbour A, Yu CY, McCrohon J, Higgins DM, Carr-White G, Mayr M, Nagel E, Puntmann VO. Native T1 in discrimination of acute and convalescent stages in patients with clinical diagnosis of myocarditis: a proposed diagnostic algorithm using CMR. JACC Cardiovasc Imaging. 2015 8 : 37-46. [PubMed] [DOI]

118 Willeit J, Geley T, Schch J, Rinner H, Tr A, Kreuzer H, Thiemann N, Knoflach M, Toell T, Pechlaner R, Willeit K, Klingler N, Praxmarer S, Baubin M, Beck G, Berek K, Dengg C, Engelhardt K, Erlacher T, Fluckinger T, Grander W, Grossmann J, Kathrein H, Kaiser N, Matosevic B, Matzak H, Mayr M, Perfler R, Poewe W, Rauter A, Schoenherr G, Schoenherr HR, Schinnerl A, Spiss H, Thurner T, Vergeiner G, Werner P, Wll E, Willeit P, Kiechl S. Thrombolysis and clinical outcome in patients with stroke after implementation of the Tyrol Stroke Pathway: a retrospective observational study. The Lancet Neurology. 2015 14 : 48-56. [PubMed] [DOI]

119 Skroblin P, Mayr M. "Going Long": Long Non-Coding RNAs as Biomarkers. Circ Res. 2014 115 : 607-609. [Full Text] [PubMed] [DOI]

120 Braza-Boïls A, Mayr M. LDL-receptor-deficient mice lacking microRNA-143/145 have less atherosclerosis. Thromb Haemost. 2014 112 : 629. [Full Text] [PubMed] [DOI]

121 Zampetaki A, Attia RQ, Mayr U, Gomes RS, Phinikaridou A, Yin X, Langley S, Willeit P, Lu R, Fanshawe B, Fava M, Barallobre-Barreiro J, Molenaar C, So PW, Abbas A, Jahangiri M, Waltham M, Botnar R, Smith A, Mayr M. Role of miR-195 in Aortic Aneurysmal Disease. Circ Res. 2014 115 : 857-866. [Full Text] [PubMed] [DOI]

122 Willeit P, Kiechl S, Kronenberg F, Witztum JL, Santer P, Mayr M, Xu Q, Mayr A, Willeit J, Tsimikas S. Discrimination and Net Reclassification of Cardiovascular Risk With Lipoprotein(a): Prospective 15-Year Outcomes in the Bruneck Study. J Am Coll Cardiol. 2014 64 : 851. [Full Text] [PubMed] [DOI]

123 Goedeke L, Salerno A, Ramírez CM, Guo L, Allen RM, Yin X, Langley SR, Esau C, Wanschel A, Fisher EA, Suárez Y, Baldán A, Mayr M, Fernández-Hernando C. Long-term therapeutic silencing of miR-33 increases circulating triglyceride levels and hepatic lipid accumulation in mice. EMBO Mol Med. 2014 18 : 1133-1141. [Full Text] [PubMed] [DOI]

124 Cuello F, Shankar-Hari M, Mayr U, Yin X, Marshall M, Suna G, Willeit P, Langley SR, Jayawardhana T, Zeller T, Terblanche M, Shah AM, Mayr M. Redox-state of pentraxin 3 as a novel biomarker for resolution of inflammation and survival in sepsis. Mol Cell Proteomics. 2014 13 : 2545-2557. [Full Text] [PubMed] [DOI]

125 Bang C, Batkai S, Dangwal S, Gupta SK, Foinquinos A, Holzmann A, Just A, Remke J, Zimmer K, Zeug A, Ponimaskin E, Schmiedl A, Yin X, Mayr M, Halder R, Fischer A, Engelhardt S, Wei Y, Schober A, Fiedler J, Thum T. Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy. J Clin Invest. 2014 124 : 2136-2146. [Full Text] [PubMed] [DOI]

126 Suna G, Mayr M. Tracing the proteomic fingerprint of the diabetic aorta?. Circ Cardiovasc Genet. 2014 7 : 100-101. [Full Text] [PubMed] [DOI]

127 Tarone G, Balligand JL, Bauersachs J, Clerk A, De Windt L, Heymans S, Hilfiker-Kleiner D, Hirsch E, Iaccarino G, Knöll R, Leite-Moreira AF, Lourenço AP, Mayr M, Thum T, Tocchetti CG. Targeting myocardial remodelling to develop novel therapies for heart failure: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology. Eur J Heart Fail. 2014 16 : 494-508. [Full Text] [PubMed] [DOI]

128 Stegemann C, Pechlaner R, Willeit P, Langley S, Mangino M, Mayr U, Menni C, Moayyeri A, Santer P, Rungger G, Spector TD, Willeit J, Kiechl S, Mayr M. Lipidomics Profiling and Risk of Cardiovascular Disease in the Prospective Population-Based Bruneck Study. Circulation. 2014 129 : 1821-1831. [Full Text] [PubMed] [DOI]

129 Leite-Moreira AF, Lourenço AP, Balligand JL, Bauersachs J, Clerk A, De Windt LJ, Heymans S, Hilfiker-Kleiner D, Hirsch E, Iaccarino G, Kaminski KA, Knöll R, Mayr M, Tarone G, Thum T, Tocchetti CG. ESC Working Group on Myocardial Function Position Paper: how to study the right ventricle in experimental models. Eur J Heart Fail. 2014 16 : 509-518. [Full Text] [PubMed] [DOI]

130 Beyer C, Zampetaki A, Lin NY, Kleyer A, Perricone C, Iagnocco A, Distler A, Langley SR, Gelse K, Sesselmann S, Lorenzini R, Niemeier A, Swoboda B, Distler JH, Santer P, Egger G, Willeit J, Mayr M, Schett G, Kiechl S. Signature of circulating microRNAs in osteoarthritis. Ann Rheum Dis. 2014 Epub ahead : . [Full Text] [PubMed] [DOI]

131 Mayr M, Lee R, Kaudewitz D, Zampetaki A, Channon KM. Effects of heparin on temporal microRNA profiles. J Am Coll Cardiol. 2014 63 : 940-941. [Full Text] [PubMed] [DOI]

132 Candasamy AJ, Haworth RS, Cuello F, Ibrahim M, Aravamudhan S, Krüger M, Holt MR, Terracciano CM, Mayr M, Gautel M, Avkiran M. Phosphoregulation of the titin-cap protein telethonin in cardiac myocytes. J Biol Chem. 2014 289 : 1282-1293. [Full Text] [PubMed] [DOI]

133 Drozdov I, Didangelos A, Yin X, Zampetaki A, Abonnenc M, Murdoch C, Zhang M, Ouzounis CA, Mayr M, Tsoka S, Shah AM. Gene Network and Proteomic Analyses of Cardiac Responses to Pathological and Physiological Stress. Circ Cardiovasc Genet. 2013 6 : 588-597. [Full Text] [PubMed] [DOI]

134 Xiao Q, Zhang F, Grassia G, Hu Y, Zhang Z, Xing Q, Yin X, Maddaluno M, Drung B, Schmidt B, Maffia P, Ialenti A, Mayr M, Xu Q, Ye S. Matrix Metalloproteinase-8 Promotes Vascular Smooth Muscle Cell Proliferation and Neointima Formation. Arterioscler Thromb Vasc Biol. 2014 34 : 90-98. [Full Text] [PubMed] [DOI]

135 Mayr M, Rabilloud T. Multidimensional separation prior to mass spectrometry: getting closer to the bottom of the iceberg.. Proteomics. 2013 13 : 2942-2943. [Full Text] [PubMed] [DOI]

136 Zeng L, Wang G, Ummarino D, Margariti A, Xu Q, Xiao Q, Wang W, Zhang Z, Yin X, Mayr M, Cockerill G, Li JY, Chien S, Hu Y, Xu Q. Histone deacetylase 3 unconventional splicing mediates endothelial-to-mesenchymal transition through transforming growth factor beta2. J Biol Chem. 2013 288 : 31853-31866. [Full Text] [PubMed] [DOI]

137 El Azzouzi H, Leptidis S, Dirkx E, Hoeks J, van Bree B, Brand K, McClellan EA, Poels E, Sluimer JC, van den Hoogenhof MM, Armand AS, Yin X, Langley S, Bourajjaj M, Olieslagers S, Krishnan J, Vooijs M, Kurihara H, Stubbs A, Pinto YM, Krek W, Mayr M, da Costa Martins PA, Schrauwen P, De Windt LJ. The Hypoxia-Inducible MicroRNA Cluster miR-199a~214 Targets Myocardial PPARdelta and Impairs Mitochondrial Fatty Acid Oxidation. Cell Metab. 2013 18 : 341-354. [Full Text] [PubMed] [DOI]

138 Abonnenc M, Nabeebaccus AA, Mayr U, Barallobre-Barreiro J, Dong X, Cuello F, Sur S, Drozdov I, Langley S, Lu R, Stathopoulou K, Didangelos A, Yin X, Zimmermann WH, Shah AM, Zampetaki A, Mayr M. Extracellular Matrix Secretion by Cardiac Fibroblasts: Role of microRNA-29b and microRNA-30c. Circ Res. 2013 113 : 1138-1147. [Full Text] [PubMed] [DOI]

139 Cheng X, Chapple SJ, Patel B, Puszyk W, Sudgen D, Yin X, Mayr M, Siow RCM, Mann GE. Gestational diabetes impairs Nrf2-mediated adaptive antioxidant defenses and redox signaling in fetal endothelial cells in utero. Diabetes. 2013 62 : 4088-4097. [Full Text] [PubMed] [DOI]

140 Heymans S, Corsten MF, Verhesen W, Carai P, van Leeuwen RE, Custers K, Peters T, Hazebroek M, Stöger L, Wijnands E, Janssen BJ, Creemers EE, Pinto YM, Grimm D, Schürmann N, Vigorito E, Thum T, Stassen F, Yin X, Mayr M, De Windt LJ, Lutgens E, Wouters K, d. Macrophage MicroRNA-155 Promotes Cardiac Hypertrophy and Failure. Circulation. 2013 128 : 1420-1432. [Full Text] [PubMed] [DOI]

141 Mayr M. Vascular proteomics - the forgotten blood vessels. Proteomics Clin Appl. 2013 7 : 463. [PubMed] [DOI]

142 Mayr M, Zampetaki A, Kiechl S. MicroRNA biomarkers for failing hearts?. Eur Heart J. 2013 34 : 2782-2783. [Full Text] [PubMed] [DOI]

143 Barallobre-Barreiro J, Chung YL, Mayr M. Proteomics and metabolomics for mechanistic insights and biomarker discovery in cardiovascular disease. Rev Esp Cardiol. 2013 66 : 657-661. [Full Text] [PubMed] [DOI]

144 Kaudewitz D, Lee R, Willeit P, McGregor R, Markus HS, Kiechl S, Zampetaki A, Storey RF, Channon KM, Mayr M. Impact of intravenous heparin on quantification of circulating microRNAs in patients with coronary artery disease. Thromb Haemost. 2013 110 : 609-615. [Full Text] [PubMed] [DOI]

145 Zampetaki A, Dudek K, Mayr M. Oxidative stress in atherosclerosis: The role of microRNAs in arterial remodeling. Free Radic Biol Med. 2013 64 : 69-77. [Full Text] [PubMed] [DOI]

146 Abdulkareem N, Skroblin P, Jahangiri M, Mayr M. Proteomics in aortic aneurysm - What have we learnt so far?. Proteomics Clin Appl. 2013 7 : 504-515. [Full Text] [PubMed] [DOI]

147 Dalli J, Montero-Melendez T, Norling LV, Yin X, Hinds C, Haskard D, Mayr M, Perretti M. Heterogeneity in neutrophil microparticles reveals distinct proteome and functional properties. Mol Cell Proteomics. 2013 12 : 2205-2219. [Full Text] [PubMed] [DOI]

148 Barallobre-Barreiro J, Didangelos A, Yin X, Domönech N, Mayr M. A sequential extraction methodology for cardiac extracellular matrix prior to proteomics analysis. Methods Mol Biol. 2013 1005 : 215-223. [PubMed] [DOI]

149 Mayr M, Watkins MT. Endothelial Seeding for Abdominal Aortic Aneurysms: Lessons Learned from the Past and Present. Circulation. 2013 127 : 1847-1849. [Full Text] [PubMed] [DOI]

150 Puntmann VO, Voigt T, Chen Z, Mayr M, Karim R, Rhode K, Pastor A, Carr-White G, Razavi R, Schaeffter T, Nagel E. Native t1 mapping in differentiation of normal myocardium from diffuse disease in hypertrophic and dilated cardiomyopathy. JACC Cardiovasc Imaging. 2013 6 : 475-484. [PubMed] [DOI]

151 Mayr M. From data gathering to systems medicine. Cardiovasc Res. 2013 97 : 599-600. [Full Text] [PubMed] [DOI]

152 Yin X, Bern M, Xing Q, Ho J, Viner R, Mayr M. Glycoproteomic analysis of the secretome of human endothelial cells. Mol Cell Proteomics. 2013 12 : 956-978. [Full Text] [PubMed] [DOI]

153 Mayr M, Zampetaki A, Willeit P, Willeit J, Kiechl S. MicroRNAs within the Continuum of Postgenomics Biomarker Discovery. Arterioscl Thromb Vasc Biol. 2013 33 : 206-214. [Full Text] [PubMed] [DOI]

154 Willeit P, Zampetaki A, Dudek K, Kaudewitz D, King A, Kirkby NS, Crosby-Nwaobi R, Prokopi M, Drozdov I, Langley SR, Sivaprasad S, Markus HS, Mitchell JA, Warner TD, Kiechl S, Mayr M. Circulating microRNAs as novel biomarkers for platelet activation. Circ Res. 2013 112 : 595-600. [Full Text] [PubMed] [DOI]

155 Yin X, Dwyer J, Langley S, Mayr U, Xing Q, Drozdov I, Nabeebaccus A, Shah A, Madhu B, Griffiths J, Edwards LM, Mayr M. Effects of Perhexiline-Induced Fuel Switch on the Cardiac Proteome and Metabolome. J Mol Cell Cardiol. 2013 55 : 27-30. [Full Text] [PubMed] [DOI]

156 Stegemann C, Didangelos A, Barallobre-Barreiro J, Langley S, Mandal K, Jahangiri M, Mayr M. Proteomic Identification of Matrix Metalloproteinase Substrates in the Human Vasculature. Circ Cardiovasc Genet. 2013 6 : 106-117. [Full Text] [PubMed] [DOI]

157 Frömel T, Kohlstedt K, Popp R, Yin X, Awwad K, Barbosa-Sicard E, Thomas AC, Lieberz R, Mayr M, Fleming I. Cytochrome P4502S1: a novel monocyte / macrophage fatty acid epoxygenase in human atherosclerotic plaques. Basic Res Cardiol. 2013 108 : 319. [Full Text] [PubMed] [DOI]

158 Langley SR, Dwyer J, Drozdov I, Yin X, Mayr M. Proteomics: from single molecules to biological pathways. Cardiovasc Res. 2013 97 : 612-622. [Full Text] [PubMed] [DOI]

159 Tsimikas S, Willeit P, Willeit J, Santer P, Mayr M, Xu Q, Mayr A, Witztum JL, Kiechl S. Oxidation-specific biomarkers, prospective 15-year cardiovascular and stroke outcomes, and net reclassification of cardiovascular events. J Am Coll Cardiol. 2012 60 : 2218-2229. [Full Text] [PubMed] [DOI]

160 Xiao Q, Zhang F, Lin L, Fang C, Wen G, Tsai TN, Pu X, Sims D, Zhang Z, Yin X, Thomaszewski B, Schmidt B, Mayr M, Suzuki K, Xu Q, Ye S. A Functional Role of Matrix Metalloproteinase-8 in Stem/Progenitor Cell Migration and Their Recruitment into Atherosclerotic Lesions. Circ Res. 2013 112 : 35-47. [Full Text] [PubMed] [DOI]

161 Zampetaki A, Willeit P, Tilling L, Drozdov I, Prokopi M, Renard JM, Mayr A, Weger S, Schett G, Shah A, Boulanger CM, Willeit J, Chowienczyk PJ, Kiechl S, Mayr M. Prospective Study on Circulating MicroRNAs and Risk of Myocardial Infarction. J Am Coll Cardiol. 2012 60 : 290-299. [Full Text] [PubMed] [DOI]

162 Randriamboavonjy V, Isaak J, Elgheznawy A, Pistrosch F, Frömel T, Yin X, Badenhoop K, Heide H, Mayr M, Fleming I. Calpain inhibition stabilizes the platelet proteome and reactivity in diabetes. Blood. 2012 120 : 415-423. [Full Text] [PubMed] [DOI]

163 Zampetaki A, Mayr M. Analytical challenges and technical limitations in assessing circulating miRNAs. Thromb Haemost. 2012 108 : 592-598. [Full Text] [PubMed] [DOI]

164 Didangelos A, Mayr U, Monaco C, Mayr M. Novel role of ADAMTS-5 protein in proteoglycan turnover and lipoprotein retention in atherosclerosis. J Biol Chem. 2012 287 : 19341-19345. [Full Text] [PubMed] [DOI]

165 Hergenreider E, Heydt S, Tréguer K, Boettger T, Horrevoets AJ, Zeiher AM, Scheffer MP, Frangakis AS, Yin X, Mayr M, Braun T, Urbich C, Boon RA, Dimmeler S. Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs. Nat Cell Biol. 2012 14 : 249-256. [Full Text] [PubMed] [DOI]

166 Thum T, Mayr M. Review focus on the role of microRNA in cardiovascular biology and disease. Cardiovasc Res. 2012 93 : 543-544. [Full Text] [PubMed] [DOI]

167 Didangelos A, Yin X, Mayr M. Method for Protein Subfractionation of Cardiovascular Tissues Before DIGE Analysis. Methods Mol Biol. 2012 854 : 287-297. [PubMed] [DOI]

168 Zampetaki A, Mayr M. MicroRNAs in Vascular and Metabolic Disease. Circ Res. 2012 110 : 508-522. [Full Text] [PubMed] [DOI]

169 Barallobre-Barreiro J, Didangelos A, Schoendube FA, Drozdov I, Yin X, Fernández-Caggiano M, Willeit P, Puntmann VO, Aldama-Lápez G, Shah AM, Doménech N, Mayr M. Proteomics Analysis of Cardiac Extracellular Matrix Remodeling in a Porcine Model of Ischemia-Reperfusion Injury. Circulation. 2012 125 : 789-802. [Full Text] [PubMed] [DOI]

170 Zampetaki A, Willeit P, Drozdov I, Kiechl S, Mayr M. Profiling of circulating microRNAs: from single biomarkers to re-wired networks.. Cardiovasc Res.. 2012 93 : 555-562. [Full Text] [PubMed] [DOI]

171 Didangelos A, Stegemann C, Mayr M. The -omics era: Proteomics and lipidomics in vascular research.. Atherosclerosis. 2012 221 : 12-17. [Full Text] [PubMed] [DOI]

172 Tiburcy M, Didié M, Boy O, Christalla P, Döker S, Naito H, Karikkineth BC, El-Armouche A, Grimm M, Nose M, Eschenhagen T, Zieseniss A, Katschinksi DM, Hamdani N, Linke WA, Yin X, Mayr M, Zimmermann WH. Terminal differentiation, advanced organotypic maturation, and modeling of hypertrophic growth in engineered heart tissue. Circ Res. 2011 109 : 1105-1114. [Full Text] [PubMed] [DOI]

173 Mayr M. Recent highlights of metabolomics in cardiovascular research.. Circ Cardiovasc Genet. 2011 4 : 463-464. [Full Text] [PubMed] [DOI]

174 Kourliouros A, Yin X, Didangelos A, Hosseini MT, Valencia O, Mayr M, Jahangiri M. Substrate modifications precede the development of atrial fibrillation after cardiac surgery: a proteomic study. Ann Thorac Surg. 2011 92 : 104-110. [Full Text] [PubMed] [DOI]

175 Xiao Q, Wang G, Yin X, Luo Z, Margariti A, Zeng L, Mayr M, Ye S, Xu Q. Chromobox Protein Homolog 3 Is Essential for Stem Cell Differentiation to Smooth Muscles In Vitro and in Embryonic Arteriogenesis. Arterioscler Thromb Vasc Biol. 2011 31 : 1842-1852. [Full Text] [PubMed] [DOI]

176 Golinska M, Troy H, Chung YL, McSheehy PMJ, Mayr M, Yin X, Ly L, Williams KJ, Airley R, Harris AL, Latigo J, Perumal M, Aboagye E, Perrett D, Stubbs M, Griffiths JR. Adaptation to HIF-1 deficiency by upregulation of the AMP/ATP ratio and phosphofructokinase activation in hepatomas. BMC Cancer. 2011 11 : 198. [Full Text] [PubMed] [DOI]

177 Didangelos A, Yin X, Mandal K, Saje A, Smith A, Xu Q, Jahangiri M, Mayr M. Extracellular matrix composition and remodeling in human abdominal aortic aneurysms: a proteomics approach. Mol Cell Proteomics. 2011 10 : M111.00812. [Full Text] [PubMed] [DOI]

178 Kapustin A, Davies JD, Reynolds JL, McNair R, Jones GT, Sidibe A, Schurgers LJ, Skepper JN, Proudfoot D, Mayr M, Shanahan CM. Calcium Regulates Key Components of Vascular Smooth Muscle Cell-Derived Matrix Vesicles to Enhance Mineralization. Circ Res. 2011 109 : e1-e12. [Full Text] [PubMed] [DOI]

179 Stegemann C, Drozdov I, Shalhoub J, Humphries J, Ladroue C, Didangelos A, Baumert M, Allen M, Davies AH, Monaco C, Smith A, Xu Q, Mayr M. Comparative Lipidomics Profiling of Human Atherosclerotic Plaques. Circ Cardiovasc Genet. 2011 4 : 232-242. [Full Text] [PubMed] [DOI]

180 Mayr M, May D, Oren G, Madhu B, Gilon D, Yin X, Xing Q, Drozdov I, Ainali C, Tsoka S, Xu Q, Griffiths J, Horrevoets A, Keshet E. Metabolic homeostasis is maintained in myocardial hibernation by adaptive changes in the transcriptome and proteome. J Mol Cell Cardiol. 2011 50 : 982-990. [Full Text] [PubMed] [DOI]

181 Prokopi M, Mayr M. Proteomics: a reality-check for putative stem cells. Circ Res. 2011 108 : 499-511. [Full Text] [PubMed] [DOI]

182 Mayr M, Fukuda K. Cardiovascular stem cells revisited. J Mol Cell Cardiol. 2011 50 : 257. [Full Text] [PubMed] [DOI]

183 Charles RL, Burgoyne JR, Mayr M, Weldon SM, Hubner N, Dong H, Morisseau C, Hammock BD, Landar AL, Eaton P. Redox Regulation of Soluble Epoxide Hydrolase by 15-Deoxy-{Delta}-Prostaglandin J2 Controls Coronary Hypoxic Vasodilation. Circ Res. 2011 108 : 324-334. [Full Text] [PubMed] [DOI]

184 Urbich C, De Souza A, Rossig L, Yin X, Xing Q, Prokopi M, Drozdov I, Steiner M, Breuss J, Xu Q, Dimmeler S, Mayr M. Proteomic characterisation of human early pro-angiogenic cells. J Mol Cell Cardiol. 2010 50 : 333-336. [Full Text] [PubMed] [DOI]

185 Abonnenc M, Stegemann C, Mayr M. Highlights from the 2010 BAS/BSCR spring meeting: New Frontiers in Cardiovascular Research. Expert Rev Proteomics. 2010 7 : 811-813. [Full Text] [PubMed] [DOI]

186 Pula G, Perera S, Sidibe A, Prokopi M, Mayr M. Proteomic analysis of secretory proteins and vesicles in vascular research. Proteomics Clin Appl. 2008 2 : 882-891. [Full Text] [PubMed] [DOI]

187 Mayr M, Van Eyk J. Cardiovascular Proteomics. Proteomics Clin Appl. 2008 2 : 785-786. [Full Text] [PubMed] [DOI]

188 Burgoyne JR, Rudyk O, Mayr M, Eaton P. Nitrosative protein oxidation is modulated during early endotoxemia. Nitric Oxide. 2011 25 : 118-124. [Full Text] [PubMed] [DOI]

189 Rossini A, Frati C, Lagrasta C, Graiani G, Scopece A, Cavalli S, Musso E, Baccarin M, Di Segni M, Fagnoni F, Germani A, Quaini E, Mayr M, Xu Q, Barbuti A, Difrancesco D, Pompilio G, Quaini F, Gaetano C, Capogrossi MC. Human cardiac and bone marrow stromal cells exhibit distinctive properties related to their origin. Cardiovasc Res. 2011 89 : 650-660. [Full Text] [PubMed] [DOI]

190 Zampetaki A, Kiechl S, Drozdov I, Willeit P, Mayr U, Prokopi M, Mayr A, Weger S, Oberhollenzer F, Bonora E, Shah A, Willeit J, Mayr M. Plasma MicroRNA Profiling Reveals Loss of Endothelial MiR-126 and Other MicroRNAs in Type 2 Diabetes. Circ Res. 2010 107 : 810-817. [Full Text] [PubMed] [DOI]

191 Kourliouros A, Valencia O, Hosseini MT, Mayr M, Sarsam M, Camm J, Jahangiri M. Preoperative high-dose atorvastatin for prevention of atrial fibrillation after cardiac surgery: a randomized controlled trial. J Thorac Cardiovasc Surg. 2011 141 : 244-248. [PubMed] [DOI]

192 Puntmann VO, Taylor PC, Mayr M. Coupling Vascular and Myocardial Inflammatory Injury into a Common Phenotype of Cardiovascular Dysfunction: Systemic Inflammation and Aging - A Mini-Review. Gerontology. 2010 57 : 295-303. [Full Text] [PubMed] [DOI]

193 Didangelos A, Yin X, Mandal K, Baumert M, Jahangiri M, Mayr M. Proteomic characterization of extracellular spaceComponents in the human aorta. Mol Cell Proteomics. 2010 9 : 2048-2062. [Full Text] [PubMed] [DOI]

194 Fleissner F, Jazbutyte V, Fiedler J, Gupta SK, Yin X, Xu Q, Galuppo P, Kneitz S, Mayr M, Ertl G, Bauersachs J, Thum T. Asymmetric Dimethylarginine Impairs Angiogenic Progenitor Cell Function in Patients With Coronary Artery Disease Through a MicroRNA-21-Dependent Mechanism. Circ Res. 2010 107 : 138-143. [Full Text] [PubMed] [DOI]

195 Simper D, Mayr U, Urbich C, Zampetaki A, Prokopi M, Didangelos A, Saje A, Mueller M, Benbow U, Newby A, Apweiler R, Rahman S, Dimmeler S, Xu Q, Mayr M. Comparative Proteomics Profiling Reveals Role of Smooth Muscle Progenitors in Extracellular Matrix Production. Arterioscler Thromb Vasc Biol. 2010 30 : 1325-1332. [Full Text] [PubMed] [DOI]

196 Margariti A, Zampetaki A, Xiao Q, Zhou B, Karamariti E, Martin D, Yin X, Mayr M, Li H, Zhang Z, De Falco E, Hu Y, Cockerill G, Xu Q, Zeng L. Histone Deacetylase 7 Controls Endothelial Cell Growth Through Modulation of beta-Catenin. Circ Res. 2010 106 : 1202-1211. [Full Text] [PubMed] [DOI]

197 Yin X, Cuello F, Mayr U, Hao Z, Hornshaw M, Ehler E, Avkiran M, Mayr M. Proteomic analysis of the cardiac myofilament subproteome reveals dynamic alterations in phosphatase subunit distribution. Mol Cell Proteomics. 2010 9 : 497-509. [Full Text] [PubMed] [DOI]

198 Mayr M, Grainger D, Mayr U, Leroyer AS, Leseche G, Sidibe A, Herbin O, Yin X, Gomes A, Madhu B, Griffiths JR, Xu Q, Tedgui A, Boulanger CM. Proteomics, Metabolomics, and Immunomics on Microparticles Derived from Human Atherosclerotic Plaques. Circ Cardiovasc Genet. 2009 2 : 379-388. [Full Text] [PubMed] [DOI]

199 Mayr M. Metabolomics: Ready for the Prime Time?. Circ Cardiovasc Genet. 2008 1 : 58-65. [Full Text] [PubMed] [DOI]

200 Puntmann VO, Mayr M. Phenotyping transgenic animals - An integrated readout of pathophysiology by combining proteomics and metabolomics with cardiovascular imaging (Editorial). J Mol Cell Cardiol. 2010 48 : 571-573. [Full Text] [PubMed] [DOI]

201 Tunica DG, Yin X, Sidibe A, Stegemann C, Nissum M, Zeng L, Brunet M, Mayr M. Proteomic analysis of the secretome of human umbilical vein endothelial cells using a combination of free-flow electrophoresis and nanoflow LC-MS/MS. Proteomics. 2009 9 : 4991. [Full Text] [PubMed] [DOI]

202 Jacquet S, Yin X, Sicard P, Clark J, Skanaganayagam GS, Mayr M, Marber MS. Identification of cardiac myosin binding protein C as a candidate biomarker of myocardial infarction by proteomic analysis. Mol Cell Proteomics. 2009 8 : 2687-2699. [Full Text] [PubMed] [DOI]

203 Prokopi M, Pula G, Mayr U, Devue C, Gallagher J, Xiao Q, Boulanger CM, Westwood N, Urbich C, Willeit J, Steiner M, Breuss J, Xu Q, Kiechl S, Mayr M. Proteomic analysis reveals presence of platelet microparticles in endothelial progenitor cell cultures. Blood. 2009 114 : 723. [Full Text] [PubMed] [DOI]

204 Didangelos A, Simper D, Monaco C, Mayr M. Proteomics of acute coronary syndromes. Curr Atheroscler Rep. 2009 11 : 188-195. [Full Text] [PubMed]

205 Kiechl S, Lee T, Santer P, Thompson G, Tsimikas S, Egger G, Holt DW, Willeit J, Xu Q, Mayr M. Asymmetric and symmetric dimethylarginines are of similar predictive value for cardiovascular risk in the general population. Atherosclerosis. 2009 205 : 261-265. [Full Text] [PubMed] [DOI]

206 Mayr M, Liem D, Zhang J, Li X, Avliyakulov NK, Yang JI, Young G, Vondriska TM, Ladroue C, Madhu B, Griffiths JR, Gomes A, Xu Q, Ping P. Proteomic and metabolomic analysis of cardioprotection: Interplay between protein kinase C epsilon and delta in regulating glucose metabolism of murine hearts. J Mol Cell Cardiol. 2009 46 : 268-277. [Full Text] [PubMed] [DOI]

207 Pula G, Mayr U, Evans C, Prokopi M, Vara DS, Yin X, Astroulakis Z, Xiao Q, Hill J, Xu Q, Mayr M. Proteomics identifies thymidine phosphorylase as a key regulator of the angiogenic potential of colony-forming units and endothelial progenitor cell cultures. Circ Res. 2009 104 : 32-40. [Full Text] [PubMed] [DOI]

208 Mayr M, Zampetaki A, Sidibe A, Mayr U, Yin X, De Souza AI, Chung YL, Madhu B, Quax PH, Hu Y, Griffiths JR, Xu Q. Proteomic and Metabolomic Analysis of Smooth Muscle Cells Derived From the Arterial Media and Adventitial Progenitors of Apolipoprotein E-Deficient Mice. Circ Res. 2008 102 : 1046-1056. [Full Text] [PubMed] [DOI]

209 Mayr M, Sidibe A, Zampetaki A. The paradox of hypoxic and oxidative stress in atherosclerosis. J Am Coll Cardiol. 2008 51 : 1266-1267. [PubMed] [DOI]

210 Mayr M, Yusuf S, Weir G, Chung Y-L, Mayr U, Yin X, Ladroue C, Madhu B, Roberts N, De Souza A, Fredericks S, Stubbs M, Griffiths JR, Jahangiri M, Xu Q, Camm JA. Combined metabolomic and proteomic analysis of human atrial fibrillation. J Am Coll Cardiol. 2008 51 : 585-594. [Full Text] [PubMed] [DOI]

211 Sidibe A, Yin X, Tarelli E, Xiao Q, Zampetaki A, Xu Q, Mayr M. Integrated Membrane Protein Analysis of Mature and Embryonic Stem Cell-derived Smooth Muscle Cells using a Novel Combination of Cy-dye/Biotin Labelling. Mol Cell Proteomics. 2007 6 : 1788-1797. [Full Text] [PubMed] [DOI]

212 Kiechl S, Willeit J, Mayr M, Viehweider B, Oberhollenzer M, Kronenberg F, Wiedermann CJ, Oberthaler S, Xu Q, Witztum JL, Tsimikas S. Oxidized phospholipids, lipoprotein(a), lipoprotein-associated phospholipase A2 activity, and 10-year cardiovascular outcomes: prospective results from the Bruneck study. Arterioscler Thromb Vasc Biol. 2007 27 : 1788-1795. [Full Text] [PubMed] [DOI]

213 Cuello F, Bardswell SC, Haworth RS, Yin X, Lutz S, Wieland T, Mayr M, Kentish JC, Avkiran M. Protein Kinase D Selectively Targets Cardiac Troponin I and Regulates Myofilament Ca2+ Sensitivity in Ventricular Myocytes. Circ Res. 2007 100 : 864-873. [Full Text] [PubMed] [DOI]

214 Mayr M, Madhu B, Xu Q. Proteomics and metabolomics combined in cardiovascular research. Trends Cardiovasc Med. 2007 17 : 43-48. [Full Text] [PubMed] [DOI]

215 Yin X, Mayr M, Xiao Q, Wang W, Xu Q. Proteomic Analysis Reveals Higher Demand for Antioxidant Protection in Embryonic Stem Cell-derived Smooth Muscle Cells. Proteomics. 2006 6 : 6437-6446. [Full Text] [PubMed] [DOI]

216 Hussain MB, Puentmann VO, Mayr M, Khong T, Singer DRJ. The role of oxidant stress in angiotensin II-mediated contraction of human resistance arteries in the state of health and the presence of cardiovascular disease. Vasc Pharmacol. 2006 45 : 395-399. [PubMed]

217 Mayr M, Kiechl S, Tsimikas S, Miller E, Sheldon J, Willeit J, Witztum JL, Xu Q. Oxidized low-density lipoprotein autoantibodies, chronic infections, and carotid atherosclerosis in a population-based study. J Am Coll Cardiol. 2006 47 : 2436-2443. [Full Text] [PubMed] [DOI]

218 Tsimikas S, Kiechl S, Willeit J, Mayr M, Miller ER, Kronenberg F, Xu Q, Bergmark C, Weger S, Oberhollenzer F, Witztum JL. Oxidized phospholipids predict the presence and progression of carotid and femoral atherosclerosis and symptomatic cardiovascular disease: five-year prospective results from the Bruneck study. JACC. 2006 47 : 2219-2228. [Full Text] [PubMed] [DOI]

219 Mayr M, Zhang J, Greene AS, Gutterman DD, Perloff JK, Ping P. Proteomic based development of biomarkers in cardiovascular disease: Mechanistic, clinical, and therapeutic insights.. Mol Cell Proteomics. 2006 5 : 1853-1864. [Full Text] [PubMed] [DOI]

220 Xiao Q, Mandal K, Schett G, Mayr M, Wick G, Oberhollenzer F, Willeit J, Kiechl S, Xu Q. Association of Serum Soluble Heat Shock Protein 60 with Carotid Atherosclerosis: Clinical Significance Determined in a Follow-Up Study. Stroke. 2005 36 : 2571-2576. [PubMed]

221 Puntmann V, Hussain M, Mayr M, Xu Q, Singer D. Role of oxidative stress in angiotensin-II mediated contraction of human conduit arteries in patients with cardiovascular disease. Vasc Pharmacol. 2005 43 : 277-282. [PubMed]

222 Mayr U, Mayr M, Yin X, Begum S, Tarelli E, Wait R, Xu Q. Proteomic dataset of mouse aortic smooth muscle cells. Proteomics. 2005 5 : 4546-4557. [Full Text] [PubMed] [DOI]

223 Yin X, Mayr M, Xiao Q, Mayr U, Tarelli E, Wait R, Wang W, Xu Q. Proteomic dataset of Sca-1+ progenitor cells. Proteomics. 2005 5 : 4533-4545. [Full Text] [PubMed] [DOI]

224 Mayr M, Chung YL, Mayr U, Yin X, Ly L, Troy H, Fredericks S, Hu Y, Griffiths JR, Xu Q. Proteomic and Metabolomic Analyses of Atherosclerotic Vessels From Apolipoprotein E-Deficient Mice Reveal Alterations in Inflammation, Oxidative Stress, and Energy Metabolism. Arterioscler. Thromb. Vasc. Biol. 2005 25 : 2135-2142. [Full Text] [PubMed] [DOI]

225 Mayr M, Mayr U, Chung Y-L, Yin X, Griffiths JR, Xu Q. Vascular proteomics: linking proteomic and metabolomic changes. Proteomics. 2004 4 : 3751-3761. [Full Text] [PubMed] [DOI]

226 Mayr M, Mandal K, Xu Q. Pitfalls of proteomics. Circulation. 2004 110 : e316. [Full Text] [PubMed] [DOI]

227 Mayr M, Metzler B, Chung YL, McGregor E, Mayr U, Troy H, Hu Y, Leitges M, Pachinger O, Griffiths JR Dunn MJ, Xu Q. Ischemic preconditioning exaggerates cardiac damage in PKC-delta null mice. Am J Physiol Heart Circ Physiol. 2004 287 : H946-H956. [Full Text] [PubMed] [DOI]

228 Mayr M, Chung YL, Mayr U, McGregor E, Troy H, Baier G, Leitges M, Dunn MJ, Griffiths JR, Xu Q. Loss of PKC-delta alters cardiac metabolism. Am J Physiol Heart Circ Physiol. 2004 287 : H937-H945. [Full Text] [PubMed] [DOI]

229 Mayr M, Siow R, Chung YL, Mayr U, Griffiths JR, Xu Q. Proteomic and metabolomic analysis of vascular smooth muscle cells: role of PKCdelta. Circ Res. 2004 94 : e87-96. [Full Text] [PubMed] [DOI]

230 Perschinka H, Mayr M, Milonig G, Mayerl C, van der Zee R, Morrison SG, Morrison RP, Xu Q, and Wick G. Crossreactive B-cell epitopes of microbial and human heat shock protein 60/65 in atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 2003 23 : 1060-1065. [Full Text] [PubMed] [DOI]

231 Wernig F, Mayr M, and Xu Q. Mechanical stretch-induced apoptosis in smooth muscle cells is mediated by beta1-integrin signaling pathways. Hypertension. 2003 41 : 903-911. [Full Text] [PubMed] [DOI]

232 Mayr M, Kiechl S, Willeit J, Wick G and Xu Q. Increased risk of atherosclerosis is confined to CagA positive H pylori strains: Prospective results from the Bruneck study. Stroke. 2003 34 : 610-615. [Full Text] [PubMed] [DOI]

233 Hu Y, Mayr M, Erdel M, Davison F, and Xu Q. Both donor and recipient origins of smooth muscle cells in vein graft atherosclerotic lesions. Circ Res. 2002 91 : e13-e19. [Full Text] [PubMed]

234 Hu Y, Davison F, Ludewig B, Erdel M, Mayr M, Url M, Dietrich H, and Xu Q. Smooth muscle cells in transplant atherosclerotic lesions are originated from recipients, but not bone marrow progenitor cells. Circulation. 2002 106 : 1834-1839. [Full Text] [PubMed] [DOI]

235 Kiechl S, Egger G, Oberhollenzer F, Mayr M, Xu Q, Poewe W, and Willeit J. Active and passive smoking, chronic infections and the risk of carotid atherosclerosis: Perspective results from the Bruneck Study. Stroke. 2002 33 : 2170-2176. [Full Text] [PubMed]

236 Mayr M, Hu Y, Hainaut P, and Xu Q. Mechanical stress-induced DNA damage and rac-p38MAPK signal pathways mediate p53-dependent apoptosis in vascular smooth muscle cells. FASEB J. 2002 16 : 1423-1425. [Full Text] [PubMed] [DOI]

237 Mayr U, Mayr M, Li C, Wernig F, Dietrich H, Hu Y, and Xu Q. Loss of p53 accelerates neointimal lesions of vein bypass grafts in mice. Circ Res. 2002 90 : 197-204. [Full Text] [PubMed]

238 Leitges M, Mayr M, Braun U, Mayr U, Li C, Pfister G, Ghaffari-Tabrizi N, Baier G, Hu Y, and Xu Q. Exacerbated vein graft arteriosclerosis in PKCdelta-null mice. J Clin Invest. 2001 108 : 1505-1512. [Full Text] [PubMed]

239 Mayr M and Xu Q. Smooth muscle cell apoptosis in atherosclerosis. Exp Gerontol. 2001 36 : 969-987. [Full Text] [PubMed] [DOI]

240 Kiechl S, Egger G, Mayr M, Wiedermann C, Bonora E, Oberhollenzer F, Muggeo M, Xu Q, Wick G, Poewe W, and Willeit J. Chronic infections and the risk of carotid atherosclerosis: Prospective results from a large population study. Circulation. 2001 103 : 1064-1070. [Full Text] [PubMed]

241 Mayr M, Kiechl S, Willeit J, Wick G, and Xu Q. Infections, immunity and atherosclerosis: Associations of antibodies to C. pneumoniae, H. pylori and cytomegalovirus with immune reactions to heat shock protein 60 and atherosclerosis. Circulation. 2000 102 : 833-839. [Full Text] [PubMed]

242 Dietrich H, Hu Y, Zou Y, Huemer U, Metzler B, Li C, Mayr M, and Xu Q. Rapid development of vein graft atheroma in apoE-deficient mice. Am J Pathol. 2000 157 : 659-669. [Full Text] [PubMed]

243 Xu Q, Schett G, Perschinka H, Mayr M, Egger G, Oberhollenzer F, Willeit J, Kiechl S and Wick G. Serum soluble heat shock protein 60 is elevated in subjects with atherosclerosis in a general population. Circulation. 2000 102 : 14-20. [Full Text] [PubMed]

244 Mayr M, Xu Q, and Wick G. Atherogenic Effects of chronic infections: The role of autoimmunity to heat shock protein 60. J Isr Med Assoc. 1999 1 : 272-277. [PubMed]

245 Zou Y, Hu Y, Mayr M, Dietrich H, Wick G, and Xu Q. Reduced neointima hyperplasia of venous bypass grafts in intercellular adhesion molecule-1-deficient mice. Circ Res. 2000 86 : 434-440. [Full Text] [PubMed]

246 Mayr M, Li C, Zou Y, Huemer U, Hu Y, and Xu Q. Biomechanical stress-induced apoptosis in vein grafts involves p38 mitogen-activated protein kinases. FASEB J. 2000 14 : 261-270. [Full Text] [PubMed]

247 Xu Q, Kiechl S, Mayr M, Metzler B, Egger G, Oberhollenzer F, Willeit J, and Wick G. Association of serum antibodies to heat shock protein 65 with carotid atherosclerosis: Clinical significance determined in a follow-up study. Circulation. 1999 100 : 1169-1174. [Full Text] [PubMed]

248 Li C, Hu Y, Mayr M, and Xu Q. Cyclic strain stress-induced mitogen-activated protein kinase (MAPK) phosphatase 1 expression in vascular smooth muscle cells is regulated by ras/rac-MAPK pathways. J Biol Chem. 1999 274 : 25273-25280. [Full Text] [PubMed]

249 Metzler B, Mayr M, Dietrich H, Singh M, Wiebe E, Xu Q, and Wick G. Inhibition of arteriosclerosis by T-cell-depletion of normocholesterolemic rabbits immunized with heat shock protein 65. Arterioscler Thromb Vasc Biol. 1999 19 : 1905-1911. [Full Text] [PubMed]

250 Mayr M, Metzler B, Kiechl S, Willeit J, Schett G, Xu Q, and Wick G. Endothelial cytotoxicity mediated by serum antibodies to heat shock proteins of E.coli and Chlamydia pneumoniae: Immune reactions to heat shock proteins as a possible link between infection and atherosclerosis. Circulation. 1999 99 : 1560-1566. [Full Text] [PubMed]

251 Wick G, Romen M, Amberger A, Metzler B, Mayr M, Falkensammer G, and Xu Q. Atherosclerosis, autoimmunity and vascular-associated lymphoid tissue (VALT). FASEB J. 1997 11 : 1199-1207. [Full Text] [PubMed]

252 Schett G, Metzler B, Mayr M, Xu Q, Amberger A, Niederwieser D, Gupta R, Mizzen L, and Wick. G. Macrophage-lysis mediated by autoantibodies to heat shock protein 65/60. Atherosclerosis. 1997 128 : 27-38. [Full Text] [PubMed] [DOI]

253 Bern M, Becker C, Tang W, Yong JK, Yin X, Mayr M, Khoo KH, Viner R. Search Strategies for Glycopeptide Identification. J Biomol Tech. 2013 24 : S33. [Full Text]

254 Zampetaki A, Fanshawe B, Mayr M. The therapeutic potential of microRNAs in heart and vascular diseases. Heart Metab. 2014 65 : 21-25. [Full Text]

255 Baig F, Mayr M. What can we learn from metabolomics?. Heart Metab. 2015 67 : 21-25. [Full Text]

256 Troy H, Chung Y-L, Mayr M, Ly L, Kaye W, Stratford I, Harris A, Griffiths J, Stubs M. Metabolic profiling of hypoxia-inducible factor 1beta deficient and wild type hepa-1 cells: Effects of hypoxia measured by 1H magnetic resonance spectroscopy. Metabolomics. 2005 1 : 293-303. [DOI]

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