Datasets
| Loos M, Klampe B, Schulze T, Yin X, Theofilatos K, Ulmer BM, Schulz C, Behrens CS, van Bergen TD, Adami E, Maatz H, Schweizer M, Brodesser S, Skryabin BV, Rozhdestvensky TS, Bodbin S, Stathopoulou K, Christ T, Denning C, Hübner N, Mayr M, Cuello F, Eschenhagen T, Hansen A. Human model of primary carnitine deficiency cardiomyopathy reveals ferroptosis as a novel mechanism. Stem Cell Reports. 2023 Sep 19:S2213-6711(23)00361-2. Online ahead of print. DOI: 10.1016/j.stemcr.2023.09.002 PubMed(s) : 37802072 |
 PXD036026 |
|
| Malnar Črnigoj M, Čerček U, Yin X, Ho MT, Repic Lampret B, Neumann M, Hermann A, Rouleau G, Suter B, Mayr M, Rogelj B. Phenylalanine-tRNA aminoacylation is compromised by ALS/FTD-associated C9orf72 C4G2 repeat RNA. Nat Commun. 2023 Sep 16;14(1):5764. DOI: 10.1038/s41467-023-41511-3 PubMed(s) : 37717009 |
PXD024527PXD042474 |
|
| Romeo SG, Secco I, Schneider E, Reumiller CM, Santos CXC, Zoccarato A, Musale V, Pooni A, Yin X, Theofilatos K, Trevelin SC, Zeng L, Mann GE, Pathak V, Harkin K, Stitt AW, Medina RJ, Margariti A, Mayr M, Shah AM, Giacca M, Zampetaki A. Human blood vessel organoids reveal a critical role for CTGF in maintaining microvascular integrity. Nat Commun. 2023 Sep 9;14(1):5552. DOI: 10.1038/s41467-023-41326-2 PubMed(s) : 37689702 |
PXD041780 |
|
| Burnap SA, Ortega-Prieto AM, Jimenez-Guardeño JM, Ali H, Takov K, Fish M, Shankar-Hari M, Giacca M, Malim MH, Mayr M. Cross-Linking Mass Spectrometry Uncovers Interactions Between High-Density Lipoproteins and the SARS-CoV-2 Spike Glycoprotein. Mol Cell Proteomics. 2023 Aug;22(8):100600. DOI: 10.1016/j.mcpro.2023.100600 PubMed(s) : 37343697 |
PXD036640PXD041438PXD041831PXD042625 |
|
| Dave J, Raad N, Mittal N, Zhang L, Fargnoli A, Oh JG, Savoia ME, Hansen J, Fava M, Yin X, Theofilatos K, Ceholski D, Kohlbrenner E, Jeong D, Wills L, Nonnenmacher M, Haghighi K, Costa KD, Turnbull IC, Mayr M, Cai CL, Kranias EG, Akar FG, Hajjar RJ, Stillitano F. Gene editing reverses arrhythmia susceptibility in humanized PLN-R14del mice: modelling a European cardiomyopathy with global impact. Cardiovasc Res. 2022 Dec 9;118(15):3140-3150. DOI: 10.1093/cvr/cvac021 PubMed(s) : 35191471 |
PXD031612 |
|
| Duregotti E, Reumiller CM, Mayr U, Hasman M, Schmidt LE, Burnap SA, Theofilatos K, Barallobre-Barreiro J, Beran A, Grandoch M, Viviano A, Jahangiri M, Mayr M. Reduced secretion of neuronal growth regulator 1 contributes to impaired adipose-neuronal crosstalk in obesity.Nat Commun. 2022 Nov 25;13(1):7269. DOI: 10.1038/s41467-022-34846-w PubMed(s) : 36433953 |
PXD031271 |
|
| Barallobre-Barreiro J, Radovits T, Fava M, Mayr U, Lin WY, Ermolaeva E, Martínez-López D, Lindberg EL, Duregotti E, Daróczi L, Hasman M, Schmidt LE, Singh B, Lu R, Baig F, Siedlar AM, Cuello F, Catibog N, Theofilatos K, Shah AM, Crespo-Leiro MG, Doménech N, Hübner N, Merkely B, Mayr M. Extracellular Matrix in Heart Failure: Role of ADAMTS5 in Proteoglycan Remodeling. Circulation. 2021 Dec 21;144(25):2021-2034. DOI: 10.1161/CIRCULATIONAHA.121.055732 PubMed(s) : 34806902 |
PXD024135PXD028887PXD028906PXD028908PXD028942 |
|
| Eijgenraam TR, Boogerd CJ, Stege NM, Oliveira Nunes Teixeira V, Dokter MM, Schmidt LE, Yin X, Theofilatos K, Mayr M, van der Meer P, van Rooij E, van der Velden J, Silljé HHW, de Boer RA. Protein Aggregation Is an Early Manifestation of Phospholamban p.(Arg14del)-Related Cardiomyopathy: Development of PLN-R14del-Related Cardiomyopathy. Circ Heart Fail. 2021 Nov;14(11):e008532. DOI: 10.1161/CIRCHEARTFAILURE.121.008532 PubMed(s) : 34587756 |
PXD024594 |
|
| Gutmann C, Khamina K, Theofilatos K, Diendorfer AB, Burnap SA, Nabeebaccus A, Fish M, McPhail MJW, O’Gallagher K, Schmidt LE, Cassel C, Auzinger G, Napoli S, Mujib SF, Trovato F, Sanderson B, Merrick B, Roy R, Edgeworth JD, Shah AM, Hayday AC, Traby L, Hackl M, Eichinger S, Shankar-Hari M, Mayr M. Association of cardiometabolic microRNAs with COVID-19 severity and mortality. Cardiovasc Res. 2021. DOI: 10.1093/cvr/cvrab338 PubMed(s) : 34755842 |
GSE176498 |
|
| Ghim M, Pang KT, Burnap SA, Baig F, Yin X, Arshad M, Mayr M, Weinberg PD. Endothelial cells exposed to atheroprotective flow secrete follistatin-like 1 protein which reduces transcytosis and inflammation. Atherosclerosis. 2021 Sep;333:56-66. DOI: 10.1016/j.atherosclerosis.2021.08.025 PubMed(s) : 34425528 |
PXD022068 |
|
| Gutmann C, Takov K, Burnap SA, Singh B, Ali H, Theofilatos K, Reed E, Hasman M, Nabeebaccus A, Fish M, McPhail MJW, O’Gallagher K, Schmidt LE, Cassel C, Rienks M, Yin X, Auzinger G, Napoli S, Mujib SF, Trovato F, Sanderson B, Merrick B, Niazi U, Saqi M, Dimitrakopoulou K, Fernández-Leiro R, Braun S, Kronstein-Wiedemann R, Doores KJ, Edgeworth JD, Shah AM, Bornstein SR, Tonn T, Hayday AC, Giacca M, Shankar-Hari M, Mayr M. SARS-CoV-2 RNAemia and proteomic biomarker trajectory inform prognostication in COVID-19 patients admitted to intensive care. Nat Comm. 2021 Jun;12:3406. DOI: 10.1038/s41467-021-23494-1 PubMed(s) : 34099652 |
PXD024089PXD024026 |
|
| Cuello F, Knaust AE, Saleem U, Loos M, Raabe J, Mosqueira D, Laufer S, Schweizer M, van der Kraak P, Flenner F, Ulmer BM, Braren I, Yin X, Theofilatos K, Ruiz‐Orera J, Patone G, Klampe B, Schulze T, Piasecki A, Pinto Y, Vink A, Hübner N, Harding S, Mayr M, Denning C, Eschenhagen T, Hansen A. Impairment of the rough endoplasmic reticulum/mitochondria compartment in human cardiomyocytes with phospholamban p.Arg14del mutation. EMBO Mol Med (2021): e13074 DOI: 10.15252/emmm.202013074 PubMed(s) : 33998164 |
PXD020175 |
|
| Price NL, Zhang X, Fernández-Tussy P, Singh AK, Burnap SA, Rotllan N, Goedeke L, Sun J, Canfrán-Duque A, Aryal B, Mayr M, Suárez Y, Fernández-Hernando C. Loss of hepatic miR-33 improves metabolic homeostasis and liver function without altering body weight or atherosclerosis. Proc Natl Acad Sci U S A. 2021 Feb 2;118(5):e2006478118 DOI: 10.1073/pnas.2006478118 PubMed(s) : 33495342 |
PXD023471 |
|
| Burnap SA, Mayr U, Shankar-Hari M, Cuello F, Thomas MR, Shah AM, Sabroe I, Storey RF, Mayr M. A proteomics-based assessment of inflammation signatures in endotoxemia. Molecular & Cellular Proteomics. 2021 Jan 1;20:100021. DOI: 10.1074/mcp.RA120.002305 PubMed(s) : 33288685 |
PXD021077 |
|
| Hohl M, Mayr M, Lang L, Nickel AG, Barallobre-Barreiro J, Yin X, Speer T, Selejan SR, Goettsch C, Erb K, Fecher-Trost C, Reil JC, Linz B, Ruf S, Hübschle T, Maack C, Böhm M, Sadowski T, Linz D. Cathepsin A contributes to left ventricular remodeling by degrading extracellular superoxide dismutase in mice. J Biol Chem. 2020 Sep 4;295(36):12605-12617. DOI: 10.1074/jbc.RA120.013488 PubMed(s) : 32647007 |
PXD019895 |
|
| Foinquinos A, Batkai S, Genschel C, Viereck J, Rump S, Gyöngyösi M, Traxler D, Riesenhuber M, Spannbauer A, Lukovic D, Weber N, Zlabinger K, Hašimbegović E, Winkler J, Fiedler J, Dangwal S, Fischer M, de la Roche J, Wojciechowski D, Kraft T, Garamvölgyi R, Neitzel S, Chatterjee S, Yin X, Bär C, Mayr M, Xiao K, Thum T. Preclinical development of a miR-132 inhibitor for heart failure treatment. Nat Commun, 2020 Jan 31;11(1):633. DOI: 10.1038/s41467-020-14349-2 PubMed(s) : 32005803 |
PXD015337 |
|
| Fava M, Barallobre-Barreiro J, Mayr U, Lu R, Didangelos A, Baig F, Lynch M, Catibog N, Joshi A, Barwari T, Yin X. Role of ADAMTS-5 in aortic dilatation and extracellular matrix remodeling. Arteriosclerosis, thrombosis, and vascular biology. 2018 Jul;38(7):1537-48. DOI: 10.1161/ATVBAHA.117.310562 PubMed(s) : 29622560 |
PXD009410 |
|
| Yin X, Baig F, Haudebourg E, Blankley RT, Gandhi T, Müller S, Reiter L, Hinterwirth H, Pechlaner R, Tsimikas S, Santer P, Willeit J, Kiechl S, Witztum JL, Sullivan A, Mayr M. Plasma Proteomics for Epidemiology: Increasing Throughput With Standard-Flow Rates. Circ Cardiovasc Genet. 2017 Dec;10(6):e001808. DOI: 10.1161/CIRCGENETICS.117.001808 PubMed(s) : 29237681 |
Panorama Dataset |
|
| Suna G, Wojakowski W, Lynch M, Barallobre-Barreiro J, Yin X, Mayr U, Baig F, Lu R, Fava M, Hayward R, Molenaar C, White SJ, Roleder T, Milewski K, Gasior P, Buszman PP, Buszman PE, Jahangiri M, Shanahan C, Hill JM, Mayr M. Extracellular Matrix Proteomics Reveals Interplay of Aggrecan and Aggrecanases in Vascular Remodeling of Stented Coronary Arteries. Circulation. 2018 Jan 9;137(2):166-183. DOI: 10.1161/CIRCULATIONAHA.116.023381 PubMed(s) : 29030347 |
PXD005726 |
|
| Langley SR, Willeit K, Didangelos A, Matic LP, Skroblin P, Barallobre-Barreiro J, Lengquist M, Rungger G, Kapustin A, Kedenko L, Molenaar C, Lu R, Barwari T, Suna G, Yin X, Iglseder B, Paulweber B, Willeit P, Shalhoub J, Pasterkamp G, Davies AH, Monaco C, Hedin U, Shanahan CM, Willeit J, Kiechl S, Mayr M. Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques. J Clin Invest. 2017 Apr 3;127(4):1546-1560. DOI: 10.1172/JCI86924 PubMed(s) : 28319050 |
PXD005130 |
|
| Barallobre-Barreiro J, Gupta SK, Zoccarato A, Kitazume-Taneike R, Fava M, Yin X, Werner T, Hirt MN, Zampetaki A, Viviano A, Chong M, Bern M, Kourliouros A, Domenech N, Willeit P, Shah AM, Jahangiri M, Schaefer L, Fischer JW, Iozzo RV, Viner R, Thum T, Heineke J, Kichler A, Otsu K, Mayr M. Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation. 2016 Sep 13;134(11):817-32. DOI: 10.1161/CIRCULATIONAHA.115.016423 PubMed(s) : 27559042 |
PXD004465 |
|
| Ulrich V, Rotllan N, Araldi E, Luciano A, Skroblin P, Abonnenc M, Perrotta P, Yin X, Bauer A, Leslie KL, Zhang P, Aryal B, Montgomery RL, Thum T, Martin K, Suarez Y, Mayr M, Fernandez-Hernando C, Sessa WC. Chronic miR-29 antagonism promotes favorable plaque remodeling in atherosclerotic mice. EMBO Mol Med. 2016 Jun 1;8(6):643-53. DOI: 10.15252/emmm.201506031 PubMed(s) : 27137489 |
PXD003938 |
|
| Barallobre-Barreiro J, Oklu R, Lynch M, Fava M, Baig F, Yin X, Barwari T, Potier D, Albadawi H, Jahangiri M, Porter K, Watkins M, Misra S, Stoughton J, Mayr M. Extracellular Matrix Remodeling in Response to Venous Hypertension: Proteomics of Human Varicose Veins. Cardiovasc Res. 2016 Jun 1;110(3):419-30. DOI: 10.1093/cvr/cvw075 PubMed(s) : 27068509 |
PXD002555 |
|
| Štalekar M , Yin X , Rebolj K , Darovic S , Troakes C , Mayr M , Shaw CE , Rogelj B. Proteomic analyses reveal that loss of TDP-43 affects RNA processing and intracellular transport. Neuroscience. 2015, 293:157-170. DOI: 10.1016/j.neuroscience.2015.02.046 PubMed(s) : 25743254 |
PXD001668 |
|
| Cuello F, Shankar-Hari M, Mayr U, Yin X, Marshall M, Suna G, Willeit P, Langley SR, Jayawardhana T, Zeller T, Terblanche M, Shah AM, Mayr M. Redox-state of pentraxin 3 as a novel biomarker for resolution of inflammation and survival in sepsis. Mol Cell Proteomics. 2014 Jun 23. pii: mcp.M114.039446. DOI: 10.1074/mcp.M114.039446 PubMed(s) : 24958171 |
PXD001020 |
|
| Yin X, Bern M, Xing Q, Ho J, Viner R, Mayr M. Glycoproteomic analysis of the secretome of human endothelial cells. Mol Cell Proteomics, 2013 Apr, 12(4):956-978. DOI: 10.1074/mcp.M112.024018 PubMed(s) : 23345538 |
PRD000733 |
|
| Barallobre-Barreiro J, Didangelos A, Schoendube F A, Drozdov I, Yin X, Fernández-Caggiano M, Willeit P, Puntmann V O, Aldama-López G, Shah A M, Doménech N, Mayr M. Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. Circulation, 2012 Feb, 125(6):789-802. DOI: 10.1161/CIRCULATIONAHA.111.056952 PubMed(s) : 22261194 |
PXD003918PXD003919PXD003926 |
|
| Didangelos A, Yin X, Mandal K, Saje A, Smith A, Xu Q, Jahangiri M, Mayr M. Extracellular matrix composition and remodeling in human abdominal aortic aneurysms: a proteomics approach. Mol Cell Proteomics, 2011 Aug, 10, 8, M111.008128. DOI: 10.1074/mcp.M111.008128 PubMed(s) : 21593211 |
PRD000416PRD000417 |
|
| Didangelos A, Yin X, Mandal K, Baumert M, Jahangiri M, Mayr M. Proteomics characterization of extracellular space components in the human aorta. Mol Cell Proteomics. 2010 Sep;9(9):2048-62. DOI: 10.1074/mcp.M110.001693 PubMed(s) : 20551380 |
PRD000269 |
|
| Yin X, Cuello F, Mayr U, Hao Z, Hornshaw M, Ehler E, Avkiran M, Mayr M. Proteomics analysis of the cardiac myofilament subproteome reveals dynamic alterations in phosphatase subunit distribution. Mol Cell Proteomics, 2010 Mar, 9(3): 497-509. DOI: 10.1074/mcp.M900275-MCP200 PubMed(s) : 20037178 |
PRD000165 |
|
| Tunica DG, Yin X, Sidibe A, Stegemann C, Nissum M, Zeng L, Brunet M, Mayr M. Proteomic analysis of the secretome of human umbilical vein endothelial cells using a combination of free-flow electrophoresis and nanoflow LC-MS/MS. Proteomics, 2009 Nov 9, 21:4991-6. DOI: 10.1002/pmic.200900065 PubMed(s) : 19810032 |
PRD000108 |