Dr. Pavel Shliaha

Pavel Shliaha

Dr. Pavel Shliaha completed his PhD in 2015 in the laboratory of Prof. Kathryn Lilley. He has experience in both academia and industry across the UK, USA, and Denmark. Throughout his career, Dr. Shliaha has made significant contributions to the fields of ion mobility, top-down proteomics, phosphosignaling, and epigenetics. He has extensive experience managing LC-MS infrastructure and served as the head of the MRC LMS proteomics core facility from 2022 to 2025 before joining our group.

EDUCATION

2014 Ph.D. in Biochemistry, University of Cambridge, UK
2010 BSc with Honours in Biochemistry, The University of Edinburgh, UK

 

CURRENT POSITION

2021 – present Head of Proteomics and Metabolomics Facility
The MRC Laboratory of Medical Sciences
UK

 

PREVIOUS POSITIONS

2020 - 2021 Senior Scientist, Merck & Co.
Chemistry, Analytical R&D – Mass Spectrometry
Kenilworth, New Jersey, USA
2018 - 2020 Dr Ronald Hendrickson Proteomics Group, postdoctoral fellow
Memorial Sloan Kettering
New York, USA
2014 - 2018 Prof Ole Nørregaard Jensen's Research Group, postdoctoral fellow
University of Southern Denmark
Odense, Denmark
2010 - 2014 Prof Kathryn Lilley's Research Group, Ph.D. training
Cambridge Centre for Proteomics
Cambridge, UK

 

AWARDS

2016-2019 Lundbeck foundation postdoc in Denmark fellowship "Development of an intact protein analysis platform and its application in stem cell and cancer biology." (£232K)
2017 Travel Grant from the Danish Cancer Society (Sep 2017). "Application of FAIMS for characterisation of histone tails in clinically relevant cancer samples". (£2.5K)
2010-2013 The Darwin Trust of Edinburgh Scholarship for Postgraduate Studies

 

PUBLICATIONS

H-INDEX | 22        PUBLICATIONS | 33        CITATIONS | 2399

  1. Shliaha PV, Jukes-Jones R, Christoforou A, Fox J, Hughes C, Langridge J, Cain K, Lilley KS. Additional precursor purification in isobaric mass tagging experiments by traveling wave ion mobility separation (TWIMS). J Proteome Res. 2014;13:3360–3369. PMID: 24854137
  2. Radzisheuskaya A, Peña-Rømer I, Lorenzini E, Koche R, Zhan Y, Shliaha PV, Cooper AJ, Fan Z, Shlyueva D, Johansen JV, Hendrickson RC, Helin K. An alternative NURF complex sustains acute myeloid leukemia by regulating the accessibility of insulator regions. EMBO J. 2023;42:e114221. PMID: 37987160
  3. Weiss JM, Hunter MV, Cruz NM, Baggiolini A, Tagore M, Ma Y, Misale S, Marasco M, Simon-Vermot T, Campbell NR, Newell F, Wilmott JS, Johansson PA, Thompson JF, Long GV, Pearson JV, Mann GJ, Scolyer RA, Waddell N, Montal ED, Huang T-H, Jonsson P, Donoghue MTA, Harris CC, Taylor BS, Xu T, Chaligné R, Shliaha PV, Hendrickson R, Jungbluth AA, Lezcano C, Koche R, Studer L, Ariyan CE, Solit DB, Wolchok JD, Merghoub T, Rosen N, Hayward NK, White RM. Anatomic position determines oncogenic specificity in melanoma. Nature. 2022;604:354–361. PMID: 35355015
  4. Shliaha PV, Baird MA, Nielsen MM, Gorshkov V, Bowman AP, Kaszycki JL, Jensen ON, Shvartsburg AA. Characterization of Complete Histone Tail Proteoforms Using Differential Ion Mobility Spectrometry. Anal Chem. 2017;89:5461–5466. PMID: 28406606
  5. Radzisheuskaya A, Shliaha PV, Grinev VV, Shlyueva D, Damhofer H, Koche R, Gorshkov V, Kovalchuk S, Zhan Y, Rodriguez KL, Johnstone AL, Keogh M-C, Hendrickson RC, Jensen ON, Helin K. Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis. Mol Cell. 2021;81:1749-1765.e8. PMID: 33657400
  6. Zhang T, Wang Y-F, Montoya A, Patrascan I, Nebioglu N, Pallikonda HA, Georgieva R, King JWD, Kramer HB, Shliaha PV, Rueda DS, Merkenschlager M. Conserved helical motifs in the IKZF1 disordered region mediate NuRD interaction and transcriptional repression. Blood. 2025;145:422–437. PMID: 39437550
  7. Shliaha PV, Bond NJ, Gatto L, Lilley KS. Effects of traveling wave ion mobility separation on data independent acquisition in proteomics studies. J Proteome Res. 2013;12:2323–2339. PMID: 23514362
  8. Wang H, Fan Z, Shliaha PV, Miele M, Hendrickson RC, Jiang X, Helin K. H3K4me3 regulates RNA polymerase II promoter-proximal pause-release. Nature. 2023;615:339–348. PMID: 36859550
  9. Hocher A, Laursen SP, Radford P, Tyson J, Lambert C, Stevens KM, Montoya A, Shliaha PV, Picardeau M, Sockett RE, Luger K, Warnecke T. Histones with an unconventional DNA-binding mode in vitro are major chromatin constituents in the bacterium Bdellovibrio bacteriovorus. Nat Microbiol. 2023;8:2006–2019. PMID: 37814071
  10. Shliaha PV, Gibb S, Gorshkov V, Jespersen MS, Andersen GR, Bailey D, Schwartz J, Eliuk S, Schwämmle V, Jensen ON. Maximizing Sequence Coverage in Top-Down Proteomics By Automated Multimodal Gas-Phase Protein Fragmentation. Anal Chem. 2018;90:12519–12526. PMID: 30252444
  11. Kim SG, Becattini S, Moody TU, Shliaha PV, Littmann ER, Seok R, Gjonbalaj M, Eaton V, Fontana E, Amoretti L, Wright R, Caballero S, Wang Z-MX, Jung H-J, Morjaria SM, Leiner IM, Qin W, Ramos RJJF, Cross JR, Narushima S, Honda K, Peled JU, Hendrickson RC, Taur Y, van den Brink MRM, Pamer EG. Microbiota-derived lantibiotic restores resistance against vancomycin-resistant Enterococcus. Nature. 2019;572:665–669. PMID: 31435014
  12. Shliaha PV, Gorshkov V, Kovalchuk SI, Schwämmle V, Baird MA, Shvartsburg AA, Jensen ON. Middle-Down Proteomic Analyses with Ion Mobility Separations of Endogenous Isomeric Proteoforms. Anal Chem. 2020;92:2364–2368. PMID: 31935065
  13. Huang X, Park K-M, Gontarz P, Zhang B, Pan J, McKenzie Z, Fischer LA, Dong C, Dietmann S, Xing X, Shliaha PV, Yang J, Li D, Ding J, Lungjangwa T, Mitalipova M, Khan SA, Imsoonthornruksa S, Jensen N, Wang T, Kadoch C, Jaenisch R, Wang J, Theunissen TW. OCT4 cooperates with distinct ATP-dependent chromatin remodelers in naïve and primed pluripotent states in human. Nat Commun. 2021;12:5123. PMID: 34446700
  14. Mulkeen SC, Saha S, Ferrara CR, Bibeva V, Wood MC, Bai JDK, Peres TV, Martinez-Martinez D, Montoya A, Shliaha P, Cabreiro F, Montrose DC. Reducing Dietary Protein Enhances the Antitumor Effects of Chemotherapy through Immune-Mediated Mechanisms. Mol Cancer Ther. 2025. doi:10.1158/1535-7163.MCT-24-0545. PMID: 40105196
  15. Duan S, Agger K, Messling J-E, Nishimura K, Han X, Peña-Rømer I, Shliaha P, Damhofer H, Douglas M, Kohli M, Pal A, Asad Y, Van Dyke A, Reilly R, Köchl R, Tybulewicz VLJ, Hendrickson RC, Raynaud FI, Gallipoli P, Poulogiannis G, Helin K. WNK1 signalling regulates amino acid transport and mTORC1 activity to sustain acute myeloid leukaemia growth. Nat Commun. 2025;16:4920. PMID: 40425534
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