Dr. Konstantinos Theofilatos

Konstantinos Theofilatos



2001-2006Bachelor of Science
Department of Computer Engineering and Informatics
University of Patras, Greece
2006-2009Master of Science in Computer Science and Engineering
Department of Computer Engineering and Informatics
University of Patras, Greece
2009-2013PhD in Computer Engineering and Informatics
Department of Computer Engineering and Informatics
University of Patras, Greece


Present Appointment

School of Cardiovascular Medicine & Sciences,
Faculty of Life Sciences & Medicine,
King’s College London, London, UK


Previous Appointment

2015-2017Co-Founder and Chief Technology Officer (CTO)
InSyBio Ltd, United Kingdom (www.insybio.com)
2013-2015Post Doctoral Researcher
Neurophysiology Unit, Medicine School, University of Patras, Greece
2014-2015Software Analyst – Computer Programmer
Information Technology Support Center of the Hellenic Army of General Staff (KEPYES)



1 Clarke R, Von Ende A, Schmidt L E, Yin X, Hill M, Hughes A D, Pechlaner R, Willeit J, Kiechl S, Watkins H, Theofilatos K, Hopewell J C, Mayr M, PROCARDIS Consortium. Apolipoprotein Proteomics for Residual Lipid-Related Risk in Coronary Heart Disease. Circulation Research. 2023 132(4) : 452-464. [Full Text] [PubMed] [DOI]

2 Schulte C, Singh B, Theofilatos K, Sörensen NA, Lehmacher J, Hartikainen T, Haller PM, Westermann D, Zeller T, Blankenberg S, Neumann JT, Mayr M . Serial measurements of protein and microRNA biomarkers to specify myocardial infarction subtypes. Journal of molecular and cellular cardiology plus. 2022 1 : 100014. [Full Text] [PubMed] [DOI]

3 Yin X, Takov K, Straube R, Voit-Bak K, Graessler J, Julius U, Tselmin S, Rodionov R, Barbir M, Walls M, Theofilatos K, Mayr M, Bornstein SR. Precision Medicine Approach for Cardiometabolic Risk Factors in Therapeutic Apheresis. Hormone and Metabolic Research. 2022 54(04) : 238-249. [PubMed] [DOI]

4 Dave J, Raad N, Mittal N, Zhang L, Fargnoli A, Oh JG, Savoia ME, Hansen J, Fava M, Yin X, Theofilatos K, Ceholski D, Kohlbrenner E, Jeong D, Wills L, Nonnenmacher M, Haghighi K, Costa KD, Turnbull IC, Mayr M, Cai C-L, Kranias EG, Akar FG, Hajjar RJ, Stillitano F. Gene editing reverses arrhythmia susceptibility in humanized PLN-R14del mice: modelling a European cardiomyopathy with global impact. Cardiovascular Research. 2022 : . [Full Text] [PubMed] [DOI]

5 Joshi A, Schmidt LE, Burnap SA, Lu R, Chan MV, Armstrong PC, Baig F, Gutmann C, Willeit P, Santer P, Barwari T, Theofilatos K, Kiechl S, Willeit J, Warner T, Mathur A, Mayr M. Neutrophil-Derived Protein S100A8/A9 Alters the Platelet Proteome in Acute Myocardial Infarction and Is Associated With Changes in Platelet Reactivity. Arteriosclerosis, thrombosis, and vascular biology. 2021 : ATVBAHA-121. [Full Text] [PubMed] [DOI]

6 Barallobre-Barreiro J, Radovits T, Fava M, Mayr U, Lin WY, Ermolaeva E, Martínez-López D, Lindberg EL, Duregotti E, Daróczi L, Hasman M, Schmidt LE, Singh B, Lu R, Baig F, Siedlar AM, Cuello F, Catibog N, Theofilatos K, Shah AM, Crespo-Leiro MG, Doménech N, Hübner N, Merkely BP, Mayr M. The Extracellular Matrix in Heart Failure: The Role of Adamts5 In Proteoglycan Remodelling. Circulation. 2021 : . [Full Text] [PubMed] [DOI]

7 Gutmann C, Khamina K, Theofilatos K, Diendorfer AB, Burnap S, Nabeebaccus A, Fish M, McPhail M, Schmidt L, Cassel C, Auzinger G. Association of cardiometabolic microRNAs with COVID-19 severity and mortality. Cardiovascular Research. 2021 : . [Full Text] [PubMed] [DOI]

8 Burnap SA, Sattler K, Pechlaner R, Duregotti E, Lu R, Theofilatos K, Takov K, Heusch G, Tsimikas S, Fernández-Hernando C, Berry SE. PCSK9 Activity Is Potentiated Through HDL Binding. Circulation Research. 2021 : . [Full Text] [PubMed] [DOI]

9 Burnap SA, Sattler K, Pechlaner R, Theofilatos K, Takov K, Heusch G, Tsimikas S, Fernández-Hernando C, Berry SE, Hall W, Notdurfter M. HDL compartmentalisation regulates PCSK9 activity. Atherosclerosis. 2021 331 : e39. [Full Text] [DOI]

10 Eijgenraam TR, Boogerd CJ, Stege NM, Oliveira Nunes Teixeira V, Dokter MM, Schmidt LE, Yin X, Theofilatos K, Mayr M, van der Meer P, van Rooij E. Protein Aggregation Is an Early Manifestation of Phospholamban p.(Arg14del)-Related Cardiomyopathy: Development of PLN-R14del–Related Cardiomyopathy. Circulation: Heart Failure. 2021 : CIRCHEARTFAILURE-121. [Full Text] [PubMed] [DOI]

11 Sangiao-Alvarellos S, Theofilatos K, Barwari T, Gutmann C, Takov K, Singh B, Juiz-Valiña P, Varela-Rodríguez BM, Outeiriño-Blanco E, Duregotti E, Zampetaki A, Lunger L, Ebenbichler C, Tilg H, García-Brao MJ, Willeit P, Mena E, Kiechl S, Cordido F, Mayr M. Metabolic recovery after weight loss surgery is reflected in serum microRNAs. BMJ Open Diabetes Research and Care. 2020 8(2) : e001441. [Full Text] [PubMed] [DOI]

12 Gutmann C, Takov K, Burnap S, Singh B, Theofilatos K, Reed E, Hasman M, Nabeebaccus A, Fish M, McPhail M, O'Gallagher K, Schmidt L, Cassel C, Rienks M, Yin X, Auzinger G, Napoli S, Mujib S, Trovato F, Sanderson B, Merrick B, Niazi U, Saqi M, Dimitrakopoulou K, Braun S, Kronstein-Wiedemann R, Doores K, Edgeworth J, Shah A, Bornstein S, Tonn T, Hayday A, Shankar-Hari M, Mayr M. SARS-CoV-2 RNAemia and proteomic biomarker trajectory inform prognostication in COVID-19 patients admitted to intensive care. . 2020 : . [Full Text] [DOI]

13 Schulte C, Barwari T, Joshi A, Theofilatos K, Zampetaki A, Barallobre-Barreiro J, Singh B, Sorensen N, Neumann JT, Zeller T, Westermann D.. Comparative Analysis of Circulating Non-Coding RNAs Versus Protein Biomarkers in the Detection of Myocardial Injury. Circulation research. 2019 Epub : . [Full Text] [PubMed] [DOI]

14 Corthesy J, Theofilatos K, Mavroudi S, Macron C, Cominetti O, Remlawi M, Ferraro F, Nuez Galindo A, Kussmann M, Likothanassis S, Dayon L.. An adaptive pipeline to maximize isobaric tagging data in large-scale MS-based proteomics. Journal of proteome research. 2018 17 : 2165-73.

15 Theofilatos K, Dimitrakopoulos C, Alexakos C, Korfiati A, Likothanassis S, Mavroudi S. InSyBio BioNets: an efficient tool for network-based biomarker discovery . EMBnet Journal. 2016 22 : 871.

16 Dimitrakopoulos C, Theofilatos K, Pegkas A, Likothanassis S, Mavroudi S. Predicting overlapping protein complexes from weighted protein interaction graphs by gradually expanding dense neighborhoods. Artif Intell Med. 2016 71 : 62-69. [Full Text] [PubMed] [DOI]

17 Nikitaki Z, Mavragani IV, Laskaratou DA, Gika V, Moskvin VP, Theofilatos K, Vougas K, Stewart RD, Georgakilas AG. Systemic mechanisms and effects of ionizing radiation: A new 'old' paradigm of how the bystanders and distant can become the players. Semin Cancer Biol. 2016 37-38 : 77-95. [Full Text] [PubMed] [DOI]

18 Korfiati A, Theofilatos K, Kleftogiannis D, Alexakos C, Likothanassis S, Mavroudi S. Predicting human miRNA target genes using a novel computational intelligent framework. Information Sciences. 2015 294 : 576-85.

19 Theofilatos K, Pavlopoulou N, Papasavvas C, Likothanassis S, Dimitrakopoulos C, Georgopoulos E, Moschopoulos C, Mavroudi S. Predicting protein complexes from weighted protein-protein interaction graphs with a novel unsupervised methodology: evolutionary enhanced Markov clustering. Artificial intelligence in medicine. 2015 63 : 181-9.

20 Kleftogiannis D, Theofilatos K, Likothanassis S, Mavroudi S. YamiPred: A novel evolutionary method for predicting pre-miRNAs and selecting relevant features. IEEE/ACM transactions on computational biology and bioinformatics. 2015 12 : 1183-92.

21 Rapakoulia T, Theofilatos K, Kleftogiannis D, Likothanasis S, Tsakalidis A, Mavroudi S . EnsembleGASVR: a novel ensemble method for classifying missense single nucleotide polymorphisms. Bioinformatics. 2014 30 : 2324-33.

22 Theofilatos K, Dimitrakopoulos C, Likothanassis S, Kleftogiannis D, Moschopoulos C, Alexakos C, Papadimitriou S, Mavroudi S. The Human Interactome Knowledge Base (HINT-KB): an integrative human protein interaction database enriched with predicted protein–protein interaction scores using a novel hybrid technique. Artificial Intelligence Review. 2014 42 : 427-443.

23 Theofilatos K, Beligiannis G, Likothanassis S. Combining evolutionary and stochastic gradient techniques for system identification. Journal of Computational and Applied Mathematics. 2009 227 : 147-60.

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