RESEARCH GROUP

Dr. Xiaoke Yin

Education
1996-2000	BSc, College of Life Sciences, Peking University, P. R. China
2002-2006	PhD, Medical Engineering Division, Dept. of Engineering, Queen Mary, University of London, UK
Present Appointment
2006-	Research Associate Cardiovascular Division, King's College London, London, UK
Previous Appointment
2000-2002	Research assistant College of Life Sciences, Peking University, China
Awards & Prizes
2005	Clinical Science Young Investigator Award

Publications

1	Tiburcy M, Didié M, Boy O, Christalla P, Döker S, Naito H, Karikkineth BC, El-Armouche A, Grimm M, Nose M, Eschenhagen T, Zieseniss A, Katschinksi DM, Hamdani N, Linke WA, Yin X, Mayr M, Zimmermann WH. Terminal differentiation, advanced organotypic maturation, and modeling of hypertrophic growth in engineered heart tissue.. *Circ Res. 2011; 109* : 1105-1114. [Full Text] [PubMed] [DOI]
2	Kourliouros A, Yin X, Didangelos A, Hosseini MT, Valencia O, Mayr M, Jahangiri M. Substrate modifications precede the development of atrial fibrillation after cardiac surgery: a proteomic study.. *Ann Thorac Surg.*. 2011; 92 : 104-110. [Full Text] [PubMed] [DOI]
3	Xiao Q, Wang G, Yin X, Luo Z, Margariti A, Zeng L, Mayr M, Ye S, Xu Q. Chromobox Protein Homolog 3 Is Essential for Stem Cell Differentiation to Smooth Muscles In Vitro and in Embryonic Arteriogenesis. *Arterioscler Thromb Vasc Biol*. 2011; 31 : 1842-1852. [Full Text] [PubMed] [DOI]
4	Didangelos A, Yin X, Mandal K, Saje A, Smith A, Xu Q, Jahangiri M, Mayr M. Extracellular matrix composition and remodeling in human abdominal aortic aneurysms: a proteomics approach. *Mol Cell Proteomics*. 2011; 10 : M111.00812. [Full Text] [PubMed] [DOI]
5	Golinska M, Troy H, Chung YL, McSheehy PMJ, Mayr M, Yin X, Ly L, Williams KJ, Airley R, Harris AL, Latigo J, Perumal M, Aboagye E, Perrett D, Stubbs M, Griffiths JR. Adaptation to HIF-1 deficiency by upregulation of the AMP/ATP ratio and phosphofructokinase activation in hepatomas. *BMC Cancer*. 2011; 11 : 198. [Full Text] [PubMed] [DOI]
6	Mayr M, May D, Oren G, Madhu B, Gilon D, Yin X, Xing Q, Drozdov I, Ainali C, Tsoka S, Xu Q, Griffiths J, Horrevoets A, Keshet E. Metabolic homeostasis is maintained in myocardial hibernation by adaptive changes in the transcriptome and proteome. *J Mol Cell Cardiol*. 2011; 50 : 982-990. [Full Text] [PubMed] [DOI]
7	Urbich C, De Souza A, Rossig L, Yin X, Xing Q, Prokopi M, Drozdov I, Steiner M, Breuss J, Xu Q, Dimmeler S, Mayr M. Proteomic characterisation of human early pro-angiogenic cells. *J Mol Cell Cardiol*. 2010; 50 : 333-336. [Full Text] [PubMed] [DOI]
8	Didangelos A, Yin X, Mandal K, Baumert M, Jahangiri M, Mayr M. Proteomic characterization of extracellular spaceComponents in the human aorta. *Mol Cell Proteomics*. 2010; 9 : 2048-2062. [Full Text] [PubMed] [DOI]
9	Fleissner F, Jazbutyte V, Fiedler J, Gupta SK, Yin X, Xu Q, Galuppo P, Kneitz S, Mayr M, Ertl G, Bauersachs J, Thum T. Asymmetric Dimethylarginine Impairs Angiogenic Progenitor Cell Function in Patients With Coronary Artery Disease Through a MicroRNA-21–Dependent Mechanism. *Circ Res. 2010; 107* : 138-143. [Full Text] [PubMed] [DOI]
10	Margariti A, Zampetaki A, Xiao Q, Zhou B, Karamariti E, Martin D, Yin X, Mayr M, Li H, Zhang Z, De Falco E, Hu Y, Cockerill G, Xu Q, Zeng L. Histone Deacetylase 7 Controls Endothelial Cell Growth Through Modulation of beta-Catenin. *Circ Res. 2010; 106* : 1202-1211. [Full Text] [PubMed] [DOI]
11	Yin X, Cuello F, Mayr U, Hao Z, Hornshaw M, Ehler E, Avkiran M, Mayr M. Proteomic analysis of the cardiac myofilament subproteome reveals dynamic alterations in phosphatase subunit distribution. *Mol Cell Proteomics*. 2010; 9 : 497-509. [Full Text] [PubMed] [DOI]
12	Tunica DG, Yin X, Sidibe A, Stegemann C, Nissum M, Zeng L, Brunet M, Mayr M. Proteomic analysis of the secretome of human umbilical vein endothelial cells using a combination of free-flow electrophoresis and nanoflow LC-MS/MS. *Proteomics*. 2009; 9 : 4991. [Full Text] [PubMed] [DOI]
13	Jacquet S, Yin X, Sicard P, Clark J, Skanaganayagam GS, Mayr M, Marber MS. Identification of cardiac myosin binding protein C as a candidate biomarker of myocardial infarction by proteomic analysis. *Mol Cell Proteomics*. 2009; 8 : 2687-2699. [Full Text] [PubMed] [DOI]
14	Mayr M, Grainger D, Mayr U, Leroyer AS, Leseche G, Sidibe A, Herbin O, Yin X, Gomes A, Madhu B, Griffiths JR, Xu Q, Tedgui A, Boulanger CM. Proteomics, Metabolomics, and Immunomics on Microparticles Derived from Human Atherosclerotic Plaques. *Circ Cardiovasc Genet*. 2009; 2 : 379-388. [Full Text] [PubMed] [DOI]
15	Pula G, Mayr U, Evans C, Prokopi M, Vara DS, Yin X, Astroulakis Z, Xiao Q, Hill J, Xu Q, Mayr M. Proteomics identifies thymidine phosphorylase as a key regulator of the angiogenic potential of colony-forming units and endothelial progenitor cell cultures. *Circ Res. 2009; 104* : 32-40. [Full Text] [PubMed] [DOI]
16	Mayr M, Zampetaki A, Sidibe A, Mayr U, Yin X, De Souza AI, Chung YL, Madhu B, Quax PH, Hu Y, Griffiths JR, Xu Q. Proteomic and Metabolomic Analysis of Smooth Muscle Cells Derived From the Arterial Media and Adventitial Progenitors of Apolipoprotein E-Deficient Mice. *Circ Res. 2008; 102* : 1046-1056. [Full Text] [PubMed] [DOI]
17	Mayr M, Yusuf S, Weir G, Chung Y-L, Mayr U, Yin X, Ladroue C, Madhu B, Roberts N, De Souza A, Fredericks S, Stubbs M, Griffiths JR, Jahangiri M, Xu Q, Camm JA. Combined metabolomic and proteomic analysis of human atrial fibrillation. *J Am Coll Cardiol*. 2008; 51 : 585-594. [Full Text] [PubMed] [DOI]
18	Sidibe A, Yin X, Tarelli E, Xiao Q, Zampetaki A, Xu Q, Mayr M. Integrated Membrane Protein Analysis of Mature and Embryonic Stem Cell-derived Smooth Muscle Cells using a Novel Combination of Cy-dye/Biotin Labelling. *Mol Cell Proteomics*. 2007; 6 : 1788-1797. [Full Text] [PubMed] [DOI]
19	Cuello F, Bardswell SC, Haworth RS, Yin X, Lutz S, Wieland T, Mayr M, Kentish JC, Avkiran M. Protein Kinase D Selectively Targets Cardiac Troponin I and Regulates Myofilament Ca2+ Sensitivity in Ventricular Myocytes. *Circ Res. 2007; 100* : 864-873. [Full Text] [PubMed] [DOI]
20	Yin X, Mayr M, Xiao Q, Wang W, Xu Q. Proteomic Analysis Reveals Higher Demand for Antioxidant Protection in Embryonic Stem Cell-derived Smooth Muscle Cells. *Proteomics*. 2006; 6 : 6437-6446. [Full Text] [PubMed] [DOI]
21	Mayr M, Chung YL, Mayr U, Yin X, Ly L, Troy H, Fredericks S, Hu Y, Griffiths JR, Xu Q. Proteomic and Metabolomic Analyses of Atherosclerotic Vessels From Apolipoprotein E-Deficient Mice Reveal Alterations in Inflammation, Oxidative Stress, and Energy Metabolism. *Arterioscler. Thromb. Vasc. Biol*. 2005; 25 : 2135-2142. [Full Text] [PubMed] [DOI]
22	Yin X, Mayr M, Xiao Q, Mayr U, Tarelli E, Wait R, Wang W, Xu Q. Proteomic dataset of Sca-1+ progenitor cells. *Proteomics*. 2005; 5 : 4533-4545. [Full Text] [PubMed] [DOI]
23	Mayr U, Mayr M, Yin X, Begum S, Tarelli E, Wait R, Xu Q. Proteomic dataset of mouse aortic smooth muscle cells. *Proteomics*. 2005; 5 : 4546-4557. [Full Text] [PubMed] [DOI]
24	Mayr M, Mayr U, Chung Y-L, Yin X, Griffiths JR, Xu Q. Vascular proteomics: linking proteomic and metabolomic changes. *Proteomics*. 2004; 4 : 3751-3761. [Full Text] [PubMed] [DOI]