Qingbo's Homepage

Professor Qingbo Xu

Degrees
	1983	MBBS, Qingdao Medical School, Qingdao, China
	1988	PhD, Peking Union Medical College, Beijing, China
	1992	MD, University of Innsbruck Medical School, Austria
Present Appointment
	2006-	Professor, BHF John Parker Chair of Cardiovascular Sciences, Cardiovascular Division, Kings College London, London, UK
Previous Appointment
	1992-1993	Postdoctoral Fellow, Institute for Biomedical Aging Research, Austrian Academy of Sciences, Innsbruck, Austria
	1994-1995	Forgarty Fellow, NIA, NIH, USA
	1995-1998	Assistant Professor, Institute for Biomedical Aging Research, Austrian Academy of Sciences, Innsbruck, Austria
	1999-2000	Associate Professor, Institute for Biomedical Aging Research, Austrian Academy of Sciences, Innsbruck, Austria
	2001-2006	Professor, John Parker Chair of Vascular Biology, Department of Cardiac and Vascular Sciences, St George's Hospital Medical School, London (HEFCE funded), UK

Recent Publications (selected from 2001-present)

1	Mayr M, Zampetaki A, Sidibe A, Mayr U, Yin X, De Souza AI, Chung YL, Madhu B, Quax PH, Hu Y, Griffiths JR, Xu Q. Proteomic and Metabolomic Analysis of Smooth Muscle Cells Derived From the Arterial Media and Adventitial Progenitors of Apolipoprotein E-Deficient Mice. *Circ Res. 2008; 102* : 1046-1056. [Full Text] [PubMed] [DOI:10.1161/CIRCRESAHA.108.174623]
2	Mayr M, Yusuf S, Weir G, Chung Y-L, Mayr U, Yin X, Ladroue C, Madhu B, Roberts N, De Souza A, Fredericks S, Stubbs M, Griffiths JR, Jahangiri M, Xu Q, Camm JA. Combined metabolomic and proteomic analysis of human atrial fibrillation. *J Am Coll Cardiol*. 2007; 51 : 585-594. [Full Text] [PubMed] [DOI:10.1016/j.jacc.2007.09.055]
3	Mayr M, Madhu B, Xu Q. Proteomics and metabolomics combined in cardiovascular research. *Trends Cardiovasc Med*. 2007; 17 : 43-48. [Full Text] [PubMed] [DOI:10.1016/j.tcm.2006.11.004]
4	Sidibe A, Yin X, Tarelli E, Xiao Q, Zampetaki A, Xu Q, Mayr M. Integrated Membrane Protein Analysis of Mature and Embryonic Stem Cell-derived Smooth Muscle Cells using a Novel Combination of Cy-dye/Biotin Labelling. *Mol Cell Proteomics*. 2007; 6 : 1788-1797. [Full Text] [PubMed] [DOI:10.1074/mcp.M600433-MCP200]
5	Yin X, Mayr M, Xiao Q, Wang W, Xu Q. Proteomic Analysis Reveals Higher Demand for Antioxidant Protection in Embryonic Stem Cell-derived Smooth Muscle Cells. *Proteomics*. 2006; 6 : 6437-6446. [Full Text] [PubMed] [DOI:10.1002/pmic.200600351]
6	Mayr U, Mayr M, Yin X, Begum S, Tarelli E, Wait R, Xu Q. Proteomic dataset of mouse aortic smooth muscle cells. *Proteomics*. 2005; 5 : 4546-4557. [Full Text] [PubMed] [DOI:10.1002/pmic.200402045]
7	Yin X, Mayr M, Xiao Q, Mayr U, Tarelli E, Wait R, Wang W, Xu Q. Proteomic dataset of Sca-1+ progenitor cells. *Proteomics*. 2005; 5 : 4533-4545. [Full Text] [PubMed] [DOI:10.1002/pmic.200402044]
8	Mayr M, Chung YL, Mayr U, Yin X, Ly L, Troy H, Fredericks S, Hu Y, Griffiths JR, Xu Q. Proteomic and Metabolomic Analyses of Atherosclerotic Vessels From Apolipoprotein E-Deficient Mice Reveal Alterations in Inflammation, Oxidative Stress, and Energy Metabolism. *Arterioscler. Thromb. Vasc. Biol*. 2005; 25 : 2135-2142. [Full Text] [PubMed] [DOI:10.1161/01.ATV.0000183928.25844.f6]
9	Mayr M, Siow R, Chung YL, Mayr U, Griffiths JR, Xu Q. Proteomic and metabolomic analysis of vascular smooth muscle cells: role of PKCdelta. *Circ Res*. 2004; 94 : e87-96. [Full Text] [PubMed] [DOI:10.1161/01.RES.0000131496.49135.1d]
10	Mayr M, Metzler B, Chung YL, McGregor E, Mayr U, Troy H, Hu Y, Leitges M, Pachinger O, Griffiths JR Dunn MJ, Xu Q. Ischemic preconditioning exaggerates cardiac damage in PKC-delta null mice. *Am J Physiol Heart Circ Physiol. 2004; 287* : H946-H956. [Full Text] [PubMed] [DOI:10.1152/ajpheart.00878.2003]
11	Mayr M, Chung YL, Mayr U, McGregor E, Troy H, Baier G, Leitges M, Dunn MJ, Griffiths JR, Xu Q. Loss of PKC-delta alters cardiac metabolism. *Am J Physiol Heart Circ Physiol. 2004; 287* : H937-H945. [Full Text] [PubMed] [DOI:10.1152/ajpheart.00877.2003]
12	Mayr M, Mandal K, Xu Q. Pitfalls of proteomics. *Circulation. 2004; 110* : e316. [Full Text] [PubMed] [DOI:10.1161/01.CIR.0000142204.34987.09]
13	Mayr M, Mayr U, Chung Y-L, Yin X, Griffiths JR, Xu Q. Vascular proteomics: linking proteomic and metabolomic changes. *Proteomics*. 2004; 4 : 3751-3761. [Full Text] [PubMed] [DOI:10.1002/pmic.200400947]
14	Schett G, Kiechl S, Redlich K, Oberhollenzer F, Weger S, Egger G, Mayr A, Jocher J, Xu Q, Pietschmann P, Teitelbaum S, Smolen J, Willeit J. Soluble RANKL and risk of nontraumatic fracture. *JAMA. 2004; 291* : 1108-1113. [PubMed]
15	Wick G, Knoflah M and Xu Q. Autoimmune and inflammatory mechanisms in atherosclerosis. *Annu Rev Immunol*. 2004; 22 : 361-403. [PubMed] [DOI:10.1146/annurev.immunol.22.012703.104644]
16	Xu Q. Mouse models of arteriosclerosis: From arterial injuries to vascular grafts. *Am J Pathol. 2004; 165* : 1-10. [Full Text] [PubMed]
17	Zal B, Kaski JC, Arno G, Akiyu JP, Xu Q, Cole D, Whelan M, Russell N, Madrigal JA, Dodi IA and Baboonian C. Heat-shock protein 60-reactive CD4+CD28null T cells in patients with acute coronary syndromes. *Circulation. 2004; 109* : 1230-1235. [PubMed]
18	Hu Y, Zhang Z, Tosney E, Afzal AR, Davison F, Metzler B and Xu Q. Abundant progenitor cells in the adventitia contribute to atherosclerosis of vein grafts in apoE-deficeint mice. *J Clin Invest. 2004; 113* : 1258-1265. [Full Text] [PubMed] [DOI:10.1172/JCI200419628]
19	Tosney E, Mayr U, Zou Y, Thompson DW, Hu Y, and Xu Q. Thrombosis and neointima formation in vein grafts are inhibited by locally applied aspirin through endothelial protection. *Circ Res*. 2004; 94 : 1466-1473. [PubMed]
20	Mandal K, Jahangiri M, Mukhin M, Poloniecki J, Camm AJ and Xu Q. Association of anti-heat shock protein 65 antibodies with development of postoperative atrial fibrillation. *Circulation. 2004; 110* : 2588-2590. [PubMed]
21	Mayr M, Kiechl S, Willeit J, Wick G and Xu Q. Increased risk of atherosclerosis is confined to CagA positive H pylori strains: Prospective results from the Bruneck study. *Stroke*. 2003; 34 : 610-615. [Full Text] [PubMed] [DOI:10.1161/01.STR.0000058481.82639.EF]
22	Metzler B, Abia R, Ahmad M, Wernig F, Pachinger O, Hu Y and Xu Q. Activation of heat shock transcription factor 1 in atherosclerosis. *Am J Pathol. 2003; 162* : 1669-1676. [Full Text] [PubMed]
23	Wernig F, Mayr M, and Xu Q. Mechanical stretch-induced apoptosis in smooth muscle cells is mediated by beta1-integrin signaling pathways. *Hypertension*. 2003; 41 : 903-911. [Full Text] [PubMed] [DOI:10.1161/01.HYP.0000062882.42265.88]
24	Perschinka H, Mayr M, Milonig G, Mayerl C, van der Zee R, Morrison SG, Morrison RP, Xu Q, and Wick G. Crossreactive B-cell epitopes of microbial and human heat shock protein 60/65 in atherosclerosis. *Arterioscler. Thromb. Vasc. Biol*. 2003; 23 : 1060-1065. [Full Text] [PubMed] [DOI:10.1161/01.ATV.0000071701.62486.49]
25	Xu Q, Zhang Z, Davison F and Hu Y. Circulating progenitor cells regenerate endothelium of vein grafts which is diminished in apoE-deficient mice. *Circ Res*. 2003; 93 : e76-e86. [Full Text] [PubMed] [DOI:10.1161/01.RES.0000097864.24725.60]
26	Schett G, Steiner CW, Xu Q, and Smolen JS. TNF mediates susceptibility to heat-induced apoptosis by downregulation of the HSF1/HSP70 stress response. *Cell Death Differ*. 2003; 10 : 1126-1136. [Full Text] [PubMed] [DOI:10.1038/sj.cdd.4401276]
27	Li C, Wernig F, Leitges M, Hu Y and Xu Q. Mechanical stress-activated PKCdelta regulates smooth muscle cell migration. *FASEB J*. 2003; 17 : 2106-2108. [Full Text] [PubMed] [DOI:10.1096/fj.03-0150fje]
28	Hu Y, Davison F, Zhang Z and Xu Q. Endothelial replacement and angiogenesis in arteriosclerotic lesions of allografts are contributed by circulating progenitor cells. *Circulation. 2003; 108* : 3122-3127. [Full Text] [PubMed] [DOI:10.1161/01.CIR.0000105722.96112.67]
29	Mayr U, Mayr M, Li C, Wernig F, Dietrich H, Hu Y, and Xu Q. Loss of p53 accelerates neointimal lesions of vein bypass grafts in mice. *Circ Res*. 2002; 90 : 197-204. [Full Text] [PubMed]
30	Kiechl S, Egger G, Oberhollenzer F, Mayr M, Xu Q, Poewe W, and Willeit J. Active and passive smoking, chronic infections and the risk of carotid atherosclerosis: Perspective results from the Bruneck Study. *Stroke*. 2002; 33 : 2170-2176. [Full Text] [PubMed]
31	Hu Y, Mayr M, Erdel M, Davison F, and Xu Q. Both donor and recipient origins of smooth muscle cells in vein graft atherosclerotic lesions. *Circ Res*. 2002; 91 : e13-e19. [Full Text] [PubMed]
32	Wernig F, and Xu Q. Mechanical stress-induced apoptosis in cardiovascular system. *Progress Biophys Mol Biol*. 2002; 78 : 105-137. [Full Text] [PubMed] [DOI:10.1016/S0079-6107(02)00008-1]
33	Mayr M, Hu Y, Hainaut P, and Xu Q. Mechanical stress-induced DNA damage and rac-p38MAPK signal pathways mediate p53-dependent apoptosis in vascular smooth muscle cells. *FASEB J*. 2002; 16 : 1423-1425. [Full Text] [PubMed] [DOI:10.1096/fj.02-0042fje]
34	Lardenoye JHP, de Vries MR, Grimbergen JM, Xu Q, van Hinsbergh VWM, van Bockel JH and Quax PHA. Accelerated atherosclerosis and calcification in vein grafts: A study in APOE3 Leiden transgenic mice. Circ Res*. 2002; 91 : 577-584. [Full Text] [PubMed] [DOI:10.1161/01.RES.0000036901.58329.D7]
35	Xu Q. Role of heat shock proteins in atherosclerosis. *Arterioscler. Thromb. Vasc. Biol*. 2002; 22 : 1547-1559. [Full Text] [PubMed] [DOI:10.1161/01.ATV.0000029720.59649.50]
36	Hu Y, Davison F, Ludewig B, Erdel M, Mayr M, Url M, Dietrich H, and Xu Q. Smooth muscle cells in transplant atherosclerotic lesions are originated from recipients, but not bone marrow progenitor cells. *Circulation. 2002; 106* : 1834-1839. [Full Text] [PubMed] [DOI:10.1161/01.CIR.0000031333.86845.DD]
37	Leitges M, Mayr M, Braun U, Mayr U, Li C, Pfister G, Ghaffari-Tabrizi N, Baier G, Hu Y, and Xu Q. Exacerbated vein graft arteriosclerosis in PKCdelta-null mice. *J Clin Invest. 2001; 108* : 1505-1512. [Full Text] [PubMed]
38	Hu Y, Baker AH, Zou Y, Newby AC, and Xu Q. Local gene transfer of tissue inhibitor of metalloproteinase-2 influences vein graft remodeling in a mouse model. *Arterioscler Thromb Vasc Biol*. 2001; 21 : 1275-1280. [Full Text] [PubMed]
39	Kiechl S, Egger G, Mayr M, Wiedermann C, Bonora E, Oberhollenzer F, Muggeo M, Xu Q, Wick G, Poewe W, and Willeit J. Chronic infections and the risk of carotid atherosclerosis: Prospective results from a large population study. *Circulation. 2001; 103* : 1064-1070. [Full Text] [PubMed]
40	Schett G, Hayer S, Tohidast-Akrad M, Schmid BJ, Lang S, Turk B, Kainberger F, Haralambous S, Kollias G, Newby AC, Xu Q, Steiner G, Smolen J. Adenovirus-based overexpression of tissue inhibitor of metalloproteinases 1 reduces tissue damage in the joints of tumor necrosis factor alpha transgenic mice. *Arthritis Rheum*. 2001; 44 : 2888-2898. [PubMed]

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