RESEARCH GROUP
Dr. Manuel Mayr
| Education
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|
|---|---|
| 1992-1998 | Medical School, University of Innsbruck, Austria |
| 1996-1998 | MD thesis, Institute of Pathophysiology, Innsbruck, Austria |
| Jan 1999 | Medical degree with distinction "sub auspiciis presidentis rei publicae" |
| 2001-2004 | PhD thesis, University of London, United Kingdom |
Present Appointment |
|
| 2006- | Senior Lecturer |
Previous Appointment |
|
| 1999-2001 | Postdoctoral scientist Institute for Biomedical Aging Research, Austrian Academy of Sciences, Innsbruck, Austria |
| 2001-2004 | Research fellow Cardiac and Vascular Sciences, St George's Hospital Medical School, London, UK |
| 2005-2006 | Lecturer |
Awards & Prizes |
|
| 1993-1998 | Scholarships of the University of Innsbruck |
| 1996 | Scholarship of the "Hans und Blanca Moser Stiftung" |
| 1996 | Travel grant of the Austrian Chemical Industry |
| 1997 | Scholarship of the Rotary Club Innsbruck |
| 1997 | Poster prize, Annual Meeting of the Austrian Society for Clinical Chemistry |
| 1997 | Best oral presentation in Cardiology, 8th European Students’ Conference |
| 1998 | Erwin Wenzel Prize of Upper Austria |
| 1999 | Prize of the Austrian Society for Allergology and Immunology |
| 1999 | Award of the Austrian Federal Minister for Science |
| 2000 | Merck, Sharp & Dohme Prize of the Austrian Atherosclerosis Society |
| 2000 | 3rd Prize Update in Thrombolysis |
| 2000 | European Vascular Biology Fellowship |
| 2002 | Young Investigator Award, British Atherosclerosis Society |
| 2005 | Intermediate Fellowship, British Heart Foundation |
| 2007 | Michael Davies Early Career Award, British Cardiovascular Society |
| 2009 | Finalist for the American Heart Association’s Functional Genomics and Translational Biology Young Investigator Award |
| 2010 | Finalist for the Irvine H. Page Young Investigator Research Award, American Heart Association, Council on Arteriosclerosis, Thrombosis and Vascular Biology |
| 2010 | John French Lecturer, British Atherosclerosis Society |
Publications
| 1 | Zampetaki A, Kiechl S, Drozdov I, Willeit P, Mayr U, Prokopi M, Mayr A, Weger S, Oberhollenzer F, Bonora E, Shah A, Willeit J, Mayr M. Plasma MicroRNA Profiling Reveals Loss of Endothelial MiR-126 and Other MicroRNAs in Type 2 Diabetes. Circ Res. 2010; Epub ahead : . [Full Text] [PubMed] [DOI] |
| 2 | Puntmann VO, Taylor PC, Mayr M. Coupling Vascular and Myocardial Inflammatory Injury into a Common Phenotype of Cardiovascular Dysfunction: Systemic Inflammation and Aging - A Mini-Review. Gerontology. 2010; Epub ahead : . [Full Text] [PubMed] [DOI] |
| 3 | Didangelos A, Yin X, Mandal K, Baumert M, Jahangiri M, Mayr M. Proteomic characterization of extracellular spaceComponents in the human aorta. Mol Cell Proteomics. 2010; Epub ahead : . [Full Text] [PubMed] [DOI] |
| 4 | Fleissner F, Jazbutyte V, Fiedler J, Gupta SK, Yin X, Xu Q, Galuppo P, Kneitz S, Mayr M, Ertl G, Bauersachs J, Thum T. Asymmetric Dimethylarginine Impairs Angiogenic Progenitor Cell Function in Patients With Coronary Artery Disease Through a MicroRNA-21–Dependent Mechanism. Circ Res. 2010; 107 : 138-143. [Full Text] [PubMed] [DOI] |
| 5 | Simper D, Mayr U, Urbich C, Zampetaki A, Prokopi M, Didangelos A, Saje A, Mueller M, Benbow U, Newby A, Apweiler R, Rahman S, Dimmeler S, Xu Q, Mayr M. Comparative Proteomics Profiling Reveals Role of Smooth Muscle Progenitors in Extracellular Matrix Production. Arterioscler Thromb Vasc Biol. 2010; 30 : 1325-1332. [Full Text] [PubMed] [DOI] |
| 6 | Margariti A, Zampetaki A, Xiao Q, Zhou B, Karamariti E, Martin D, Yin X, Mayr M, Li H, Zhang Z, De Falco E, Hu Y, Cockerill G, Xu Q, Zeng L. Histone Deacetylase 7 Controls Endothelial Cell Growth Through Modulation of beta-Catenin. Circ Res. 2010; 106 : 1202-1211. [Full Text] [PubMed] [DOI] |
| 7 | Puntmann VO, Mayr M. Phenotyping transgenic animals - An integrated readout of pathophysiology by combining proteomics and metabolomics with cardiovascular imaging (Editorial). J Mol Cell Cardiol. 2010; 48 : 571-573. [Full Text] [PubMed] [DOI] |
| 8 | Yin X, Cuello F, Mayr U, Hao Z, Hornshaw M, Ehler E, Avkiran M, Mayr M. Proteomic analysis of the cardiac myofilament subproteome reveals dynamic alterations in phosphatase subunit distribution. Mol Cell Proteomics. 2010; 9 : 497-509. [Full Text] [PubMed] [DOI] |
| 9 | Tunica DG, Yin X, Sidibe A, Stegemann C, Nissum M, Zeng L, Brunet M, Mayr M. Proteomic analysis of the secretome of human umbilical vein endothelial cells using a combination of free-flow electrophoresis and nanoflow LC-MS/MS. Proteomics. 2009; 9 : 4991. [Full Text] [PubMed] [DOI] |
| 10 | Jacquet S, Yin X, Sicard P, Clark J, Skanaganayagam GS, Mayr M, Marber MS. Identification of cardiac myosin binding protein C as a candidate biomarker of myocardial infarction by proteomic analysis. Mol Cell Proteomics. 2009; 8 : 2687-2699. [Full Text] [PubMed] [DOI] |
| 11 | Kiechl S, Lee T, Santer P, Thompson G, Tsimikas S, Egger G, Holt DW, Willeit J, Xu Q, Mayr M. Asymmetric and symmetric dimethylarginines are of similar predictive value for cardiovascular risk in the general population. Atherosclerosis. 2009; 205 : 261-265. [Full Text] [PubMed] [DOI] |
| 12 | Mayr M, Grainger D, Mayr U, Leroyer AS, Leseche G, Sidibe A, Herbin O, Yin X, Gomes A, Madhu B, Griffiths JR, Xu Q, Tedgui A, Boulanger CM. Proteomics, Metabolomics, and Immunomics on Microparticles Derived from Human Atherosclerotic Plaques. Circ Cardiovasc Genet. 2009; 2 : 379-388. [Full Text] [PubMed] [DOI] |
| 13 | Prokopi M, Pula G, Mayr U, Devue C, Gallagher J, Xiao Q, Boulanger CM, Westwood N, Urbich C, Willeit J, Steiner M, Breuss J, Xu Q, Kiechl S, Mayr M. Proteomic analysis reveals presence of platelet microparticles in endothelial progenitor cell cultures. Blood. 2009; 114 : 723. [Full Text] [PubMed] [DOI] |
| 14 | Didangelos A, Simper D, Monaco C, Mayr M. Proteomics of acute coronary syndromes. Curr Atheroscler Rep. 2009; 11 : 188-195. [Full Text] [PubMed] |
| 15 | Mayr M, Liem D, Zhang J, Li X, Avliyakulov NK, Yang JI, Young G, Vondriska TM, Ladroue C, Madhu B, Griffiths JR, Gomes A, Xu Q, Ping P. Proteomic and metabolomic analysis of cardioprotection: Interplay between protein kinase C epsilon and delta in regulating glucose metabolism of murine hearts. J Mol Cell Cardiol. 2009; 46 : 268-277. [Full Text] [PubMed] [DOI] |
| 16 | Pula G, Mayr U, Evans C, Prokopi M, Vara DS, Yin X, Astroulakis Z, Xiao Q, Hill J, Xu Q, Mayr M. Proteomics identifies thymidine phosphorylase as a key regulator of the angiogenic potential of colony-forming units and endothelial progenitor cell cultures. Circ Res. 2009; 104 : 32-40. [Full Text] [PubMed] [DOI] |
| 17 | Mayr M, Sidibe A, Zampetaki A. The paradox of hypoxic and oxidative stress in atherosclerosis. J Am Coll Cardiol. 2008; 51 : 1266-1267. |
| 18 | Mayr M. Metabolomics: Ready for the Prime Time?. Circ Cardiovasc Genet. 2008; 1 : 58-65. [Full Text] [PubMed] [DOI] |
| 19 | Mayr M, Van Eyk J. Cardiovascular Proteomics (Editorial). Proteomics Clin Appl. 2008; 2 : 785-787. [Full Text] [DOI] |
| 20 | Pula G, Perera S, Sidibe A, Prokopi M, Mayr M. Proteomic analysis of secretory proteins and vesicles in vascular research. Proteomics Clin Appl. 2008; 2 : 882-891. [Full Text] [DOI] |
| 21 | Mayr M, Zampetaki A, Sidibe A, Mayr U, Yin X, De Souza AI, Chung YL, Madhu B, Quax PH, Hu Y, Griffiths JR, Xu Q. Proteomic and Metabolomic Analysis of Smooth Muscle Cells Derived From the Arterial Media and Adventitial Progenitors of Apolipoprotein E-Deficient Mice. Circ Res. 2008; 102 : 1046-1056. [Full Text] [PubMed] [DOI] |
| 22 | Kiechl S, Willeit J, Mayr M, Viehweider B, Oberhollenzer M, Kronenberg F, Wiedermann CJ, Oberthaler S, Xu Q, Witztum JL, Tsimikas S. Oxidized phospholipids, lipoprotein(a), lipoprotein-associated phospholipase A2 activity, and 10-year cardiovascular outcomes: prospective results from the Bruneck study. Arterioscler Thromb Vasc Biol. 2007; 27 : 1788-1795. |
| 23 | Sidibe A, Yin X, Tarelli E, Xiao Q, Zampetaki A, Xu Q, Mayr M. Integrated Membrane Protein Analysis of Mature and Embryonic Stem Cell-derived Smooth Muscle Cells using a Novel Combination of Cy-dye/Biotin Labelling. Mol Cell Proteomics. 2007; 6 : 1788-1797. [Full Text] [PubMed] [DOI] |
| 24 | Cuello F, Bardswell SC, Haworth RS, Yin X, Lutz S, Wieland T, Mayr M, Kentish JC, Avkiran M. Protein Kinase D Selectively Targets Cardiac Troponin I and Regulates Myofilament Ca2+ Sensitivity in Ventricular Myocytes. Circ Res. 2007; 100 : 864-873. [Full Text] [PubMed] [DOI] |
| 25 | Mayr M, Madhu B, Xu Q. Proteomics and metabolomics combined in cardiovascular research. Trends Cardiovasc Med. 2007; 17 : 43-48. [Full Text] [PubMed] [DOI] |
| 26 | Mayr M, Yusuf S, Weir G, Chung Y-L, Mayr U, Yin X, Ladroue C, Madhu B, Roberts N, De Souza A, Fredericks S, Stubbs M, Griffiths JR, Jahangiri M, Xu Q, Camm JA. Combined metabolomic and proteomic analysis of human atrial fibrillation. J Am Coll Cardiol. 2007; 51 : 585-594. [Full Text] [PubMed] [DOI] |
| 27 | Hussain MB, Puentmann VO, Mayr M, Khong T, Singer DRJ. The role of oxidant stress in angiotensin II-mediated contraction of human resistance arteries in the state of health and the presence of cardiovascular disease. Vasc Pharmacol. 2006; 45 : 395-399. |
| 28 | Tsimikas S, Kiechl S, Willeit J, Mayr M, Miller ER, Kronenberg F, Xu Q, Bergmark C, Weger S, Oberhollenzer F, Witztum JL. Oxidized phospholipids predict the presence and progression of carotid and femoral atherosclerosis and symptomatic cardiovascular disease: five-year prospective results from the Bruneck study. JACC. 2006; 47 : 2219-2228. [Full Text] [PubMed] [DOI] |
| 29 | Yin X, Mayr M, Xiao Q, Wang W, Xu Q. Proteomic Analysis Reveals Higher Demand for Antioxidant Protection in Embryonic Stem Cell-derived Smooth Muscle Cells. Proteomics. 2006; 6 : 6437-6446. [Full Text] [PubMed] [DOI] |
| 30 | Mayr M, Zhang J, Greene AS, Gutterman DD, Perloff JK, Ping P. Proteomic based development of biomarkers in cardiovascular disease: Mechanistic, clinical, and therapeutic insights.. Mol Cell Proteomics. 2006; 5 : 1853-1864. [Full Text] [PubMed] [DOI] |
| 31 | Mayr M, Kiechl S, Tsimikas S, Miller E, Sheldon J, Willeit J, Witztum JL, Xu Q. Oxidized low-density lipoprotein autoantibodies, chronic infections, and carotid atherosclerosis in a population-based study. JACC. 2006; 47 : 2436-2443. [Full Text] [PubMed] [DOI] |
| 32 | Troy H, Chung Y-L, Mayr M, Ly L, Kaye W, Stratford I, Harris A, Griffiths J, Stubs M. Metabolic profiling of hypoxia-inducible factor 1beta deficient and wild type hepa-1 cells: Effects of hypoxia measured by 1H magnetic resonance spectroscopy. Metabolomics. 2005; 1 : 293-303. |
| 33 | Puentmann V, Hussain M, Mayr M, Xu Q, Singer D. Role of oxidative stress in angiotensin-II mediated contraction of human conduit arteries in patients with cardiovascular disease. Vasc Pharmacol. 2005; 43 : 277-282. |
| 34 | Xiao Q, Mandal K, Schett G, Mayr M, Wick G, Oberhollenzer F, Willeit J, Kiechl S, Xu Q. Association of Serum Soluble Heat Shock Protein 60 with Carotid Atherosclerosis: Clinical Significance Determined in a Follow-Up Study. Stroke. 2005; 36 : 2571-2576. |
| 35 | Mayr M, Chung YL, Mayr U, Yin X, Ly L, Troy H, Fredericks S, Hu Y, Griffiths JR, Xu Q. Proteomic and Metabolomic Analyses of Atherosclerotic Vessels From Apolipoprotein E-Deficient Mice Reveal Alterations in Inflammation, Oxidative Stress, and Energy Metabolism. Arterioscler. Thromb. Vasc. Biol. 2005; 25 : 2135-2142. [Full Text] [PubMed] [DOI] |
| 36 | Yin X, Mayr M, Xiao Q, Mayr U, Tarelli E, Wait R, Wang W, Xu Q. Proteomic dataset of Sca-1+ progenitor cells. Proteomics. 2005; 5 : 4533-4545. [Full Text] [PubMed] [DOI] |
| 37 | Mayr U, Mayr M, Yin X, Begum S, Tarelli E, Wait R, Xu Q. Proteomic dataset of mouse aortic smooth muscle cells. Proteomics. 2005; 5 : 4546-4557. [Full Text] [PubMed] [DOI] |
| 38 | Mayr M, Mayr U, Chung Y-L, Yin X, Griffiths JR, Xu Q. Vascular proteomics: linking proteomic and metabolomic changes. Proteomics. 2004; 4 : 3751-3761. [Full Text] [PubMed] [DOI] |
| 39 | Mayr M, Mandal K, Xu Q. Pitfalls of proteomics. Circulation. 2004; 110 : e316. [Full Text] [PubMed] [DOI] |
| 40 | Mayr M, Chung YL, Mayr U, McGregor E, Troy H, Baier G, Leitges M, Dunn MJ, Griffiths JR, Xu Q. Loss of PKC-delta alters cardiac metabolism. Am J Physiol Heart Circ Physiol. 2004; 287 : H937-H945. [Full Text] [PubMed] [DOI] |
| 41 | Mayr M, Metzler B, Chung YL, McGregor E, Mayr U, Troy H, Hu Y, Leitges M, Pachinger O, Griffiths JR Dunn MJ, Xu Q. Ischemic preconditioning exaggerates cardiac damage in PKC-delta null mice. Am J Physiol Heart Circ Physiol. 2004; 287 : H946-H956. [Full Text] [PubMed] [DOI] |
| 42 | Mayr M, Siow R, Chung YL, Mayr U, Griffiths JR, Xu Q. Proteomic and metabolomic analysis of vascular smooth muscle cells: role of PKCdelta. Circ Res. 2004; 94 : e87-96. [Full Text] [PubMed] [DOI] |
| 43 | Perschinka H, Mayr M, Milonig G, Mayerl C, van der Zee R, Morrison SG, Morrison RP, Xu Q, and Wick G. Crossreactive B-cell epitopes of microbial and human heat shock protein 60/65 in atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 2003; 23 : 1060-1065. [Full Text] [PubMed] [DOI] |
| 44 | Wernig F, Mayr M, and Xu Q. Mechanical stretch-induced apoptosis in smooth muscle cells is mediated by beta1-integrin signaling pathways. Hypertension. 2003; 41 : 903-911. [Full Text] [PubMed] [DOI] |
| 45 | Mayr M, Kiechl S, Willeit J, Wick G and Xu Q. Increased risk of atherosclerosis is confined to CagA positive H pylori strains: Prospective results from the Bruneck study. Stroke. 2003; 34 : 610-615. [Full Text] [PubMed] [DOI] |
| 46 | Hu Y, Davison F, Ludewig B, Erdel M, Mayr M, Url M, Dietrich H, and Xu Q. Smooth muscle cells in transplant atherosclerotic lesions are originated from recipients, but not bone marrow progenitor cells. Circulation. 2002; 106 : 1834-1839. [Full Text] [PubMed] [DOI] |
| 47 | Mayr M, Hu Y, Hainaut P, and Xu Q. Mechanical stress-induced DNA damage and rac-p38MAPK signal pathways mediate p53-dependent apoptosis in vascular smooth muscle cells. FASEB J. 2002; 16 : 1423-1425. [Full Text] [PubMed] [DOI] |
| 48 | Hu Y, Mayr M, Erdel M, Davison F, and Xu Q. Both donor and recipient origins of smooth muscle cells in vein graft atherosclerotic lesions. Circ Res. 2002; 91 : e13-e19. [Full Text] [PubMed] |
| 49 | Kiechl S, Egger G, Oberhollenzer F, Mayr M, Xu Q, Poewe W, and Willeit J. Active and passive smoking, chronic infections and the risk of carotid atherosclerosis: Perspective results from the Bruneck Study. Stroke. 2002; 33 : 2170-2176. [Full Text] [PubMed] |
| 50 | Mayr U, Mayr M, Li C, Wernig F, Dietrich H, Hu Y, and Xu Q. Loss of p53 accelerates neointimal lesions of vein bypass grafts in mice. Circ Res. 2002; 90 : 197-204. [Full Text] [PubMed] |
| 51 | Mayr M and Xu Q. Smooth muscle cell apoptosis in atherosclerosis. Exp Gerontol. 2001; 36 : 969-987. [Full Text] [PubMed] [DOI] |
| 52 | Kiechl S, Egger G, Mayr M, Wiedermann C, Bonora E, Oberhollenzer F, Muggeo M, Xu Q, Wick G, Poewe W, and Willeit J. Chronic infections and the risk of carotid atherosclerosis: Prospective results from a large population study. Circulation. 2001; 103 : 1064-1070. [Full Text] [PubMed] |
| 53 | Leitges M, Mayr M, Braun U, Mayr U, Li C, Pfister G, Ghaffari-Tabrizi N, Baier G, Hu Y, and Xu Q. Exacerbated vein graft arteriosclerosis in PKCdelta-null mice. J Clin Invest. 2001; 108 : 1505-1512. [Full Text] [PubMed] |
| 54 | Mayr M, Kiechl S, Willeit J, Wick G, and Xu Q. Infections, immunity and atherosclerosis: Associations of antibodies to C. pneumoniae, H. pylori and cytomegalovirus with immune reactions to heat shock protein 60 and atherosclerosis. Circulation. 2000; 102 : 833-839. [Full Text] [PubMed] |
| 55 | Dietrich H, Hu Y, Zou Y, Huemer U, Metzler B, Li C, Mayr M, and Xu Q. Rapid development of vein graft atheroma in apoE-deficient mice. Am J Pathol. 2000; 157 : 659-669. [Full Text] [PubMed] |
| 56 | Xu Q, Schett G, Perschinka H, Mayr M, Egger G, Oberhollenzer F, Willeit J, Kiechl S and Wick G. Serum soluble heat shock protein 60 is elevated in subjects with atherosclerosis in a general population. Circulation. 2000; 102 : 14-20. [Full Text] [PubMed] |
| 57 | Zou Y, Hu Y, Mayr M, Dietrich H, Wick G, and Xu Q. Reduced neointima hyperplasia of venous bypass grafts in intercellular adhesion molecule-1-deficient mice. Circ Res. 2000; 86 : 434-440. [Full Text] [PubMed] |
| 58 | Mayr M, Li C, Zou Y, Huemer U, Hu Y, and Xu Q. Biomechanical stress-induced apoptosis in vein grafts involves p38 mitogen-activated protein kinases. FASEB J. 2000; 14 : 261-270. [Full Text] [PubMed] |
| 59 | Mayr M, Xu Q, and Wick G. Atherogenic Effects of chronic infections: The role of autoimmunity to heat shock protein 60. J Isr Med Assoc. 1999; 1 : 272-277. [PubMed] |
| 60 | Li C, Hu Y, Mayr M, and Xu Q. Cyclic strain stress-induced mitogen-activated protein kinase (MAPK) phosphatase 1 expression in vascular smooth muscle cells is regulated by ras/rac-MAPK pathways. J Biol Chem. 1999; 274 : 25273-25280. [Full Text] [PubMed] |
| 61 | Xu Q, Kiechl S, Mayr M, Metzler B, Egger G, Oberhollenzer F, Willeit J, and Wick G. Association of serum antibodies to heat shock protein 65 with carotid atherosclerosis: Clinical significance determined in a follow-up study. Circulation. 1999; 100 : 1169-1174. [Full Text] [PubMed] |
| 62 | Metzler B, Mayr M, Dietrich H, Singh M, Wiebe E, Xu Q, and Wick G. Inhibition of arteriosclerosis by T-cell-depletion of normocholesterolemic rabbits immunized with heat shock protein 65. Arterioscler Thromb Vasc Biol. 1999; 19 : 1905-1911. [Full Text] [PubMed] |
| 63 | Mayr M, Metzler B, Kiechl S, Willeit J, Schett G, Xu Q, and Wick G. Endothelial cytotoxicity mediated by serum antibodies to heat shock proteins of E.coli and Chlamydia pneumoniae: Immune reactions to heat shock proteins as a possible link between infection and atherosclerosis. Circulation. 1999; 99 : 1560-1566. [Full Text] [PubMed] |
| 64 | Wick G, Romen M, Amberger A, Metzler B, Mayr M, Falkensammer G, and Xu Q. Atherosclerosis, autoimmunity and vascular-associated lymphoid tissue (VALT). FASEB J. 1997; 11 : 1199-1207. [Full Text] [PubMed] |
| 65 | Schett G, Metzler B, Mayr M, Xu Q, Amberger A, Niederwieser D, Gupta R, Mizzen L, and Wick. G. Macrophage-lysis mediated by autoantibodies to heat shock protein 65/60. Atherosclerosis. 1997; 128 : 27-38. [Full Text] [PubMed] [DOI] |
