Dr. Giordano Pula
Education
  1992

Scientific Diploma
Scientific School "Belfiore", Mantova, Italy
  1998

Degree in Molecular Biology
University of Parma, Italy
  2000-2003

PhD in Molecular Pharmacology,
Department of Pharmacology, University of Bristol, UK
Present Appointment
  2007-

Postdoctoral Fellow
Cardiovascular Division, King’s College, London, UK
Previous Appointment
  1998-2000 Molecular Pharmacology Unit
GlaxoSmithKline Research Centre, Verona, Italy
  2003-2006

Postdoctoral Research Associate
Department of Pharmacology, University of Bristol, UK
  2006-2007 Postdoctoral Research Associate
Randall Division, King’s College, London, UK

Publications

1 Pula G, Perera S, Sidibe A, Prokopi M, Mayr M. Proteomic analysis of secretory proteins and vesicles in vascular research. Proteomics Clin Appl. 2008; 2 : 882-891. [Full Text] [DOI:10.1002/prca.200800040]
2 Pula G, Krause M. Role of Ena/VASP Proteins in Homeostasis and Disease. Handb Exp Pharmacol. 2008; 186 : 39-65. [PubMed] [DOI:10.1007/978-3-540-72843-6_3]
3 Pula G, Poole AW. Critical roles for the actin cytoskeleton and cdc42 in regulating platelet integrin alpha2beta1. Platelets. 2008; 19 : 199-210. [PubMed] [DOI:10.1080/09537100701777303]
4 Wenworth JKT, Pula G and Poole AW. Vasodilator-stimulated phosphoprotein (VASP) is phosphorylated on Ser157 by protein kinase C-dependent and -independent mechanisms in thrombin-stimulated human platelets. Biochemical Journal. 2006; 393 : 555-564.
5 Pula G, Schuh K, Nakayama K, Nakayama KI, Walter U, Poole AW. PKCdelta regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formation. Blood. 2006; 108 : 4035-4044.
6 Pula G, Mundell SJ, Roberts PJ and Kelly E. Analysis of mGluR1a constitutive internalization using a pulse-chase enzyme-linked immuno-sorbant assay (ELISA). Journal of Biochemical and Biophysical Methods. 2005; 64 : 167-181.
7 Pula G, Crosby D, Baker J, Poole AW. Functional interaction of PKCalpha with the tyrosine kinases Syk and Src in human platelets. J. Biol. Chem. 2005; 280 : 7194-7205.
8 Mundell SJ, Pula G, More JC, Jane DE, Roberts PJ, Kelly E. Activation of cyclic AMP-dependent protein kinase inhibits the desensitization and internalization of metabotropic glutamate receptor 1a and 1b. Mol. Pharmacol. 2004; 65 : 1507-1516.
9 Mundell SJ, Pula G, McIlhinney RA, Roberts PJ, Kelly E. Desensitization and internalization of metabotropic glutamate receptor 1a following activation of heterologous Gq/11-coupled receptors. Biochemistry. 2004; 43 : 7541-7551.
10 Pula G, Mundell SJ, Roberts PJ, Kelly E. Agonist-independent internalization of metabotropic glutamate receptor 1a is arrestin- and clathrin-dependent and is suppressed by receptor inverse agonists. J. Neurochem. 2004; 89 : 1009-1020.
11 Poole AW, Pula G, Hers I, Crosby D, Jones ML. PKC-interacting proteins: from function to pharmacology. Trends Pharmacol. Sci. 2004; 25 : 528-535.
12 Mundell SJ, Pula G, Carswell K, Roberts PJ, Kelly E. Agonist-induced internalization of metabotropic glutamate receptor 1A: structural determinants for protein kinase C- and G protein-coupled receptor kinase-mediated internalization. J. Neurochem. 2003; 84 : 294-304.
13 Terstappen GC, Pellacani A, Aldegheri L, Graziani F, Carignani C, Pula G, Virginio C. The antidepressant fluoxetine blocks the human small conductance calcium-activated potassium channels SK1, SK2 and SK3. Neurosci. Lett. 2003; 346 : 85-88.
14 Mundell SJ, Matharu AL, Pula G, Holman D, Roberts PJ, Kelly E. Metabotropic glutamate receptor 1 internalization induced by muscarinic acetylcholine receptor activation: differential dependency of internalization of splice variants on nonvisual arrestins. Mol. Pharmacol. 2002; 61 : 1114-1123.
15 Terstappen GC, Pula G, Carignani C, Chen MX, Roncarati R. Pharmacological characterisation of the human small conductance calcium-activated potassium channel hSK3 reveals sensitivity to tricyclic antidepressants and antipsychotic phenothiazines. Neuropharmacology. 2001; 40 : 772-783.
16 Mundell SJ, Matharu AL, Pula G, Roberts PJ, Kelly E. Agonist-induced internalization of the metabotropic glutamate receptor 1a is arrestin- and dynamin-dependent. J. Neurochem. 2001; 78 : 546-551.
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