Dr. Anna Zampetaki

Dr. Anna Zampetaki


1994 Degree in Biology,
Aristotle University of Thessaloniki, GREECE
1996 PhD in Genetics,
Department of Genetics, Development and Molecular Biology,
School of Biology, Aristotle University of Thessaloniki, GREECE


Present Appointment

2013- Lecturer
Department of Cardiology,
King’s College London School of Medicine, London, U.K.


Previous Appointment

2000-2003 Postdoctoral Research Fellow
Children’s Hospital, Department of Newborn Medicine,
Harvard Medical School, Boston, USA.
2003-2006 Postdoctoral Research Fellow
Department of Cardiac and Vascular Sciences,
St. George’s Hospital Medical School, London, U.K.
2006-2013 Postdoctoral Research Fellow
Department of Cardiology,
King’s College London School of Medicine, London, U.K.


Professional Activities

Professional Activities

Member of the Editorial Board of Journal of Molecular and Cellular Cardiology.
Top Reviewer 2009-2010 Award for exceptional contribution to the quality of Journal of Molecular and Cellular Cardiology.

Ad Hoc reviewer for Circulation, Circulation Research, Journal of Molecular and Cellular Cardiology, American Journal of Physiology-Heart and Circulatory Physiology, American Journal of Physiology-Cell Physiology, Journal of Applied Physiology, Physiological Genomics, BMC Cell Biology, Cytotherapy and Cell Biology International.

Wellcome Trust Invited Grant Reviewer.
Medical Research Council Invited Grant Reviewer.
British Heart Foundation Invited Grant Reviewer.

Abstract Grader for the European Society of Cardiology 2014- 2015 Sessions.
European Society of Cardiology 2015 Sessions (ESC2015 Sessions) Invited Chairperson.
Scientific Advisor to the Functional Gene Annotation Programme (University College of London).

ECR Forum & Athena SWAN Seminar, ‘Establishing an Independent Research Career’ 27th of March 2014, King’s BHF Centre of Research Excellence. Invited speaker.

Athena Swan Q&A. Women in Science.
A mentoring session for female scientists with Prof Sarah J. George. 24th of April 2014, King’s BHF Centre of Research Excellence. Host: A Zampetaki.
A mentoring session for female scientists with Prof Sussan Nourshargh. 12th of May 2014, King’s BHF Centre of Research Excellence. Host: A Zampetaki.



Conferences & Oral Presentations

Zampetaki A. (2015) Circulating MicroRNAs networks as Biomarkers for Cardiovascular Diseases. RNAi2015, Oxford, UK. Invited Speaker.

Zampetaki A. (2014) Circulating MicroRNAs as biomarkers for Cardiovascular Risk. ASHG, San Diego, USA. Invited Speaker.

Zampetaki A. (2014) MicroRNA signatures in the Circulation and the Risk of Cardiovascular Diseases, Seminar QUB Centre for Experimental Medicine, Belfast, UK. Invited Speaker.

Zampetaki A. (2013) Circulating miRNAs: Rewired networks and Cardiovascular Risk. CNAS, Baltimore, USA. Invited Speaker.

Zampetaki A, Willeit P, Tilling L, Drozdov I, Mayr A, Weger S, Shah A, Boulanger C, Willeit J, Chowienczyk P, Kiechl S, Mayr M. (2012) MicroRNAs and Risk of Myocardial Infarction: Prospective Results from the Bruneck Study. AHA, Los Angeles, USA

Zampetaki A. (2012) Circulating miRNAs as Biomarkers of Cardiovascular Risk. The microRNAs & Single Molecule Meeting, Cambridge UK. Invited Speaker.

Zampetaki A. (2012) MiRNAs as novel Biomarkers in Cardiovascular Diseases. qPCR Virtual Conference, Amsterdam, The Netherlands. Invited Speaker.

Zampetaki A. (2012) Circulating miRNA networks and Cardiovascular Diseases. The King’s Genomics Centre Seminar, London, UK. Invited Speaker.

Zampetaki A. (2012) Analyzing miRNA networks. Systems and Computational Biology. Technology Seminar Series, London, UK. Invited speaker.

Zampetaki A. (2011) Plasma miRNA signatures in Diabetes. ADA, San Diego, USA. Invited speaker.

Zampetaki A, Zeng L, Margariti A, Hu Y, Xu Q. (2009) HDAC3 expression at bifurcation areas plays a critical role in preserving the endothelial monolayer and maintaining the vascular integrity. BAS BSCR, Oxford, UK

Zampetaki A, Zeng L, Margariti A, Hu Y, Xu Q. (2008) HDAC3 Is Critical in Endothelial Survival and Atherosclerosis Development in Response to Disturbed Flow. AHA, New Orleans, USA

Zampetaki A, Xu Q. (2007) Stem Cells and Vascular Diseases 13th Worth Congress on Heart Disease, Vancouver, Canada

Zampetaki A (2007) Cytokine Production in stem cell-derived vascular cells. A joint Workshop on embryonic stem cell differentiation, King’s College London, London, UK.

Zampetaki A, Xiao Q, Zeng L, Hu Y, Xu Q (2006) Vascular Cells derived from Mouse Stem cells Display a Low Inflammatory Response due to decreased TLR4 Expression. AHA, Chicago, USA



1 Schulte C, Barwari T, Joshi A, Theofilatos K, Zampetaki A, Barallobre-Barreiro J, Singh B, Sorensen N, Neumann JT, Zeller T, Westermann D.. Comparative Analysis of Circulating Non-Coding RNAs Versus Protein Biomarkers in the Detection of Myocardial Injury. Circulation research. 2019 Epub : . [Full Text] [PubMed] [DOI]

2 Barwari T, Eminaga S, Mayr U, Lu R, Armstrong PC, Chan MV, Sahraei M, Fernández-Fuertes M, Moreau T, Barallobre-Barreiro J, Lynch M, Yin X, Schulte C, Baig F, Pechlaner R, Langley SR, Zampetaki A, Santer P, Weger M, Plasenzotti R, Schosserer M, Grillari J, Kiechl S, Willeit J, Shah AM, Ghevaert C, Warner TD, Fernández-Hernando C, Suárez Y, Mayr M. Inhibition of profibrotic microRNA-21 affects platelets and their releasate. JCI Insight. 2018 3 : e123335. [Full Text] [PubMed] [DOI]

3 Lataniotis L, Albrecht A, Kok FO, Monfries CAL, Benedetti L, Lawson ND, Hughes SM, Steinhofel K, Mayr M, Zampetaki A. CRISPR/Cas9 editing reveals novel mechanisms of clustered microRNA regulation and function. Sci Rep. 2017 7 : 8585. [Full Text] [PubMed] [DOI]

4 Paschalaki KE, Zampetaki A, Baker JR, Birrell MA, Starke RD, Belvisi MG, Donnelly LE, Mayr M, Randi AM, Barnes PJ. Downregulation of MicroRNA-126 Augments DNA Damage Response in Cigarette Smokers and COPD Patients. Am J Respir Crit Care Med. 2017 197 : 665-668. [Full Text] [PubMed] [DOI]

5 Zampetaki A, Mayr M. Long Noncoding RNAs and Angiogenesis: Regulatory Information for Chromatin Remodeling. Circulation. 2017 136 : 80-82. [Full Text] [PubMed] [DOI]

6 Viviano A, Yin X, Zampetaki A, Fava M, Gallagher M, Mayr M, Jahangiri M. Proteomics of the epicardial fat secretome and its role in post-operative atrial fibrillation. Europace. 2017 20 : 1201-1208. [Full Text] [PubMed] [DOI]

7 Willeit P, Skroblin P, Moschen AR, Yin X, Kaudewitz D, Zampetaki A, Barwari T, Whitehead M, Ramírez CM, Goedeke L, Rotllan N, Bonora E, Hughes AD, Santer P, Fernández-Hernando C, Tilg H, Willeit J, Kiechl S, Mayr M.. Circulating MicroRNA-122 Is Associated With the Risk of New-Onset Metabolic Syndrome and Type 2 Diabetes. Diabetes. 2017 66 : 347-357. [Full Text] [PubMed] [DOI]

8 Barallobre-Barreiro J, Gupta SK, Zoccarato A, Kitazume-Taneike R, Fava M, Yin X, Werner T, Hirt MN, Zampetaki A, Viviano A, Chong M, Bern M, Kourliouros A, Domenech N, Willeit P, Shah AM, Jahangiri M, Schaefer L, Fischer JW, Iozzo RV, Viner R, Thum T, Heineke J, Kichler A, Otsu K, Mayr M. Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation. 2016 134 : 817-832. [Full Text] [PubMed] [DOI]

9 Huntley RP, Sitnikov D, Orlic-Milacic M, Balakrishnan R, D'Eustachio P, Gillespie ME, Howe D, Kalea AZ, Maegdefessel L, Osumi-Sutherland D, Petri V, Smith JR, Van Auken K, Wood V, Zampetaki A, Mayr M, Lovering RC. Guidelines for the functional annotation of microRNAs using the Gene Ontology. RNA. 2016 22 : 667-676. [Full Text] [PubMed] [DOI]

10 Gomes RS, Skroblin P, Munster AB, Tomlins H, Langley SR, Zampetaki A, Yin X, Wardle FC, Mayr M. "Young at heart": Regenerative potential linked to immature cardiac phenotypes. J Mol Cell Cardiol. 2016 92 : 105-108. [Full Text] [PubMed] [DOI]

11 Kaudewitz D, Skroblin P, Bender LH, Barwari T, Willeit P, Pechlaner R, Sunderland NP, Willeit K, Morton AC, Armstrong PC, Chan MV, Lu R, Yin X, Gracio F, Dudek K, Langley SR, Zampetaki A, de Rinaldis E, Ye S, Warner TD, Saxena A, Kiechl S, Storey RF, Mayr M. Association of MicroRNAs and YRNAs With Platelet Function. Circ Res. 2016 118 : 420-432. [Full Text] [PubMed] [DOI]

12 Zampetaki A, Willeit P, Burr S, Yin X, Langley SR, Kiechl S, Klein R, Rossing P, Chaturvedi N, Mayr M. Angiogenic MicroRNAs Linked to Incidence and Progression of Diabetic Retinopathy in Type 1 Diabetes. Diabetes. 2016 65 : 216-227. [Full Text] [PubMed] [DOI]

13 Kaudewitz D, Zampetaki A, Mayr M. MicroRNA Biomarkers for Coronary Artery Disease?. Curr Atheroscler Rep. 2015 17 : 70. [Full Text] [PubMed] [DOI]

14 Zeng L, Li Y, Yang J, Wang G, Margariti A, Xiao Q, Zampetaki A, Yin X, Mayr M, Mori K, Wang W, Hu Y, Xu Q. XBP 1-Deficiency Abrogates Neointimal Lesion of Injured Vessels Via Cross Talk With the PDGF Signaling. Arterioscler Thromb Vasc Biol. 2015 35 : 2134-2144. [Full Text] [PubMed] [DOI]

15 Zampetaki A, Mayr M. Sweet Dicer: Impairment of Micro-RNA Processing by Diabetes. Circ Res. 2015 117 : 116-118. [Full Text] [PubMed] [DOI]

16 Zampetaki A, Attia RQ, Mayr U, Gomes RS, Phinikaridou A, Yin X, Langley S, Willeit P, Lu R, Fanshawe B, Fava M, Barallobre-Barreiro J, Molenaar C, So PW, Abbas A, Jahangiri M, Waltham M, Botnar R, Smith A, Mayr M. Role of miR-195 in Aortic Aneurysmal Disease. Circ Res. 2014 115 : 857-866. [Full Text] [PubMed] [DOI]

17 Beyer C, Zampetaki A, Lin NY, Kleyer A, Perricone C, Iagnocco A, Distler A, Langley SR, Gelse K, Sesselmann S, Lorenzini R, Niemeier A, Swoboda B, Distler JH, Santer P, Egger G, Willeit J, Mayr M, Schett G, Kiechl S. Signature of circulating microRNAs in osteoarthritis. Ann Rheum Dis. 2014 Epub ahead : . [Full Text] [PubMed] [DOI]

18 Mayr M, Lee R, Kaudewitz D, Zampetaki A, Channon KM. Effects of heparin on temporal microRNA profiles. J Am Coll Cardiol. 2014 63 : 940-941. [Full Text] [PubMed] [DOI]

19 Zampetaki A, Fanshawe B, Mayr M. The therapeutic potential of microRNAs in heart and vascular diseases. Heart Metab. 2014 65 : 21-25. [Full Text]

20 Drozdov I, Didangelos A, Yin X, Zampetaki A, Abonnenc M, Murdoch C, Zhang M, Ouzounis CA, Mayr M, Tsoka S, Shah AM. Gene Network and Proteomic Analyses of Cardiac Responses to Pathological and Physiological Stress. Circ Cardiovasc Genet. 2013 6 : 588-597. [Full Text] [PubMed] [DOI]

21 Abonnenc M, Nabeebaccus AA, Mayr U, Barallobre-Barreiro J, Dong X, Cuello F, Sur S, Drozdov I, Langley S, Lu R, Stathopoulou K, Didangelos A, Yin X, Zimmermann WH, Shah AM, Zampetaki A, Mayr M. Extracellular Matrix Secretion by Cardiac Fibroblasts: Role of microRNA-29b and microRNA-30c. Circ Res. 2013 113 : 1138-1147. [Full Text] [PubMed] [DOI]

22 Mayr M, Zampetaki A, Kiechl S. MicroRNA biomarkers for failing hearts?. Eur Heart J. 2013 34 : 2782-2783. [Full Text] [PubMed] [DOI]

23 Kaudewitz D, Lee R, Willeit P, McGregor R, Markus HS, Kiechl S, Zampetaki A, Storey RF, Channon KM, Mayr M. Impact of intravenous heparin on quantification of circulating microRNAs in patients with coronary artery disease. Thromb Haemost. 2013 110 : 609-615. [Full Text] [PubMed] [DOI]

24 Zampetaki A, Dudek K, Mayr M. Oxidative stress in atherosclerosis: The role of microRNAs in arterial remodeling. Free Radic Biol Med. 2013 64 : 69-77. [Full Text] [PubMed] [DOI]

25 Mayr M, Zampetaki A, Willeit P, Willeit J, Kiechl S. MicroRNAs within the Continuum of Postgenomics Biomarker Discovery. Arterioscl Thromb Vasc Biol. 2013 33 : 206-214. [Full Text] [PubMed] [DOI]

26 Willeit P, Zampetaki A, Dudek K, Kaudewitz D, King A, Kirkby NS, Crosby-Nwaobi R, Prokopi M, Drozdov I, Langley SR, Sivaprasad S, Markus HS, Mitchell JA, Warner TD, Kiechl S, Mayr M. Circulating microRNAs as novel biomarkers for platelet activation. Circ Res. 2013 112 : 595-600. [Full Text] [PubMed] [DOI]

27 Zampetaki A, Willeit P, Tilling L, Drozdov I, Prokopi M, Renard JM, Mayr A, Weger S, Schett G, Shah A, Boulanger CM, Willeit J, Chowienczyk PJ, Kiechl S, Mayr M. Prospective Study on Circulating MicroRNAs and Risk of Myocardial Infarction. J Am Coll Cardiol. 2012 60 : 290-299. [Full Text] [PubMed] [DOI]

28 Zampetaki A, Mayr M. Analytical challenges and technical limitations in assessing circulating miRNAs. Thromb Haemost. 2012 108 : 592-598. [Full Text] [PubMed] [DOI]

29 Zampetaki A, Mayr M. MicroRNAs in Vascular and Metabolic Disease. Circ Res. 2012 110 : 508-522. [Full Text] [PubMed] [DOI]

30 Zampetaki A, Willeit P, Drozdov I, Kiechl S, Mayr M. Profiling of circulating microRNAs: from single biomarkers to re-wired networks.. Cardiovasc Res.. 2012 93 : 555-562. [Full Text] [PubMed] [DOI]

31 Zampetaki A, Kiechl S, Drozdov I, Willeit P, Mayr U, Prokopi M, Mayr A, Weger S, Oberhollenzer F, Bonora E, Shah A, Willeit J, Mayr M. Plasma MicroRNA Profiling Reveals Loss of Endothelial MiR-126 and Other MicroRNAs in Type 2 Diabetes. Circ Res. 2010 107 : 810-817. [Full Text] [PubMed] [DOI]

32 Simper D, Mayr U, Urbich C, Zampetaki A, Prokopi M, Didangelos A, Saje A, Mueller M, Benbow U, Newby A, Apweiler R, Rahman S, Dimmeler S, Xu Q, Mayr M. Comparative Proteomics Profiling Reveals Role of Smooth Muscle Progenitors in Extracellular Matrix Production. Arterioscler Thromb Vasc Biol. 2010 30 : 1325-1332. [Full Text] [PubMed] [DOI]

33 Margariti A, Zampetaki A, Xiao Q, Zhou B, Karamariti E, Martin D, Yin X, Mayr M, Li H, Zhang Z, De Falco E, Hu Y, Cockerill G, Xu Q, Zeng L. Histone Deacetylase 7 Controls Endothelial Cell Growth Through Modulation of beta-Catenin. Circ Res. 2010 106 : 1202-1211. [Full Text] [PubMed] [DOI]

34 Zampetaki A, Zeng L, Margariti A, Xiao Q, Li H, Zhang Z, Pepe AE, Wang G, Habi O, deFalco E, Cockerill G, Mason JC, Hu Y, Xu Q. Histone deacetylase 3 is critical in endothelial survival and atherosclerosis development in response to disturbed flow. Circulation. 2010 121 : 132-142. [PubMed] [DOI]

35 Zeng L, Zampetaki A, Margariti A, Li H, Zhang Z, Pepe AE, Alam S, Martin D, Xiao Q, Wang W, Jin Z, Cockerill G, Mori K, Hu Y, Xu Q. Sustained Activation of XBP1 Splicing Leads to Endothelial Cell Apoptosis and Atherosclerosis Development. Proc Natl Acad Sci U S A. 2009 106 : 8326-8331. [PubMed] [DOI]

36 Margariti A, Xiao Q, Zampetaki A, Zhang Z, Li H, Hu Y, Zeng L, Xu Q. HDAC7 Splicing Induces Smooth Muscle Cell Differentiation from Embryonic Stem Cells through Modulation of MEF2C. J Cell Sci. 2009 122 : 460-470. [PubMed] [DOI]

37 Zampetaki A, Xu Q. Vascular remodeling in diabetes: don't leave without your STAT5. Arterioscler Thromb Vasc Biol. 2009 29 : 10-11. [PubMed] [DOI]

38 Mayr M, Zampetaki A, Sidibe A, Mayr U, Yin X, De Souza AI, Chung YL, Madhu B, Quax PH, Hu Y, Griffiths JR, Xu Q. Proteomic and Metabolomic Analysis of Smooth Muscle Cells Derived From the Arterial Media and Adventitial Progenitors of Apolipoprotein E-Deficient Mice. Circ Res. 2008 102 : 1046-1056. [Full Text] [PubMed] [DOI]

39 Mayr M, Sidibe A, Zampetaki A. The paradox of hypoxic and oxidative stress in atherosclerosis. J Am Coll Cardiol. 2008 51 : 1266-1267. [PubMed] [DOI]

40 Zampetaki A, Kirton JP, Xu Q. Vascular repair by endothelial progenitor cells. Cardiovasc Res. 2008 78 : 413-421. [PubMed] [DOI]

41 Sidibe A, Yin X, Tarelli E, Xiao Q, Zampetaki A, Xu Q, Mayr M. Integrated Membrane Protein Analysis of Mature and Embryonic Stem Cell-derived Smooth Muscle Cells using a Novel Combination of Cy-dye/Biotin Labelling. Mol Cell Proteomics. 2007 6 : 1788-1797. [Full Text] [PubMed] [DOI]

42 Zampetaki A, Zeng L, Xiao Q, Margariti A, Hu Y, Xu Q. Lacking cytokine production in ES cells and ES-cell-derived vascular cells stimulated by TNF-alpha is rescued by HDAC inhibitor trichostatin A. Am J Physiol Cell Physiol. 2007 293 : C1226-C1238. [PubMed]

43 Zeng L, Xiao Q, Margariti A, Zhang Z, Zampetaki A, Patel S, Capogrossi MC, Hu Y, Xu Q. HDAC3 is crucial in shear- and VEGF-induced stem cell differentiation toward endothelial cells. J Cell Biol. 2006 174 : 1059-1069. [PubMed]

44 Zampetaki A, Xiao Q, Zeng L, Hu Y, Xu Q. TLR4 expression in mouse embryonic stem cells and in stem cell-derived vascular cells is regulated by epigenetic modifications. Biochem Biophys Res Commun. 2006 347 : 89-99. [PubMed]

45 Zampetaki A, Zhang Z, Hu Y, Xu Q. Biomechanical stress induces IL-6 expression in smooth muscle cells via Ras/Rac1-p38 MAPK-NF-kappaB signaling pathways. Am J Physiol Heart Circ Physiol. 2005 288 : H2946-2954. [PubMed]

46 Zampetaki A, Mitsialis SA, Pfeilschifter J, Kourembanas S. Hypoxia induces macrophage inflammatory protein-2 (MIP-2) gene expression in murine macrophages via NF-kappaB: the prominent role of p42/p44 and PI3 kinase pathways. FASEB J. 2004 18 : 1090-1092. [PubMed]

47 Zampetaki A, Minamino T, Mitsialis SA, Kourembanas S. Effect of heme oxygenase-1 overexpression in two models of lung inflammation. Exp Biol Med. 2003 228 : 442-446. [PubMed]