Dr. Giordano Pula

Dr. Giordano Pula

Education


1992 Scientific Diploma
Scientific School “Belfiore”, Mantova, Italy
1998 Degree in Molecular Biology
University of Parma, Italy
2000-2003 PhD in Molecular Pharmacology,
Department of Pharmacology, University of Bristol, UK

 

Previous Appointment

Previous Appointment


1998-2000 Molecular Pharmacology Unit
GlaxoSmithKline Research Centre, Verona, Italy
2003-2006 Postdoctoral Research Associate
Department of Pharmacology, University of Bristol, UK
2006-2007 Postdoctoral Research Associate
Randall Division, King’s College, London, UK
2007-2009 Postdoctoral Fellow
Cardiovascular Division, King’s College, London, UK

 

Publications


1 Prokopi M, Pula G, Mayr U, Devue C, Gallagher J, Xiao Q, Boulanger CM, Westwood N, Urbich C, Willeit J, Steiner M, Breuss J, Xu Q, Kiechl S, Mayr M. Proteomic analysis reveals presence of platelet microparticles in endothelial progenitor cell cultures. Blood. 2009 114 : 723. [Full Text] [PubMed] [DOI]

2 Pula G, Mayr U, Evans C, Prokopi M, Vara DS, Yin X, Astroulakis Z, Xiao Q, Hill J, Xu Q, Mayr M. Proteomics identifies thymidine phosphorylase as a key regulator of the angiogenic potential of colony-forming units and endothelial progenitor cell cultures. Circ Res. 2009 104 : 32-40. [Full Text] [PubMed] [DOI]

3 Pula G, Perera S, Sidibe A, Prokopi M, Mayr M. Proteomic analysis of secretory proteins and vesicles in vascular research. Proteomics Clin Appl. 2008 2 : 882-891. [Full Text] [PubMed] [DOI]

4 Pula G, Krause M. Role of Ena/VASP Proteins in Homeostasis and Disease. Handb Exp Pharmacol. 2008 186 : 39-65. [PubMed] [DOI]

5 Pula G, Poole AW. Critical roles for the actin cytoskeleton and cdc42 in regulating platelet integrin alpha2beta1. Platelets. 2008 19 : 199-210. [PubMed] [DOI]

6 Pula G, Schuh K, Nakayama K, Nakayama KI, Walter U, Poole AW. PKCdelta regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formation. Blood. 2006 108 : 4035-4044. [PubMed]

7 Wenworth JKT, Pula G and Poole AW. Vasodilator-stimulated phosphoprotein (VASP) is phosphorylated on Ser157 by protein kinase C-dependent and -independent mechanisms in thrombin-stimulated human platelets. Biochemical Journal. 2006 393 : 555-564. [PubMed]

8 Pula G, Mundell SJ, Roberts PJ and Kelly E. Analysis of mGluR1a constitutive internalization using a pulse-chase enzyme-linked immuno-sorbant assay (ELISA). J Biochem Biophys Methods. 2005 64 : 167-181. [PubMed]

9 Pula G, Crosby D, Baker J, Poole AW. Functional interaction of PKCalpha with the tyrosine kinases Syk and Src in human platelets. J Biol Chem. 2005 280 : 7194-7205. [PubMed]

10 Poole AW, Pula G, Hers I, Crosby D, Jones ML. PKC-interacting proteins: from function to pharmacology. Trends Pharmacol. Sci. 2004 25 : 528-535. [PubMed]

11 Mundell SJ, Pula G, McIlhinney RA, Roberts PJ, Kelly E. Desensitization and internalization of metabotropic glutamate receptor 1a following activation of heterologous Gq/11-coupled receptors. Biochemistry. 2004 43 : 7541-7551. [PubMed]

12 Mundell SJ, Pula G, More JC, Jane DE, Roberts PJ, Kelly E. Activation of cyclic AMP-dependent protein kinase inhibits the desensitization and internalization of metabotropic glutamate receptor 1a and 1b. Mol. Pharmacol. 2004 65 : 1507-1516. [PubMed]

13 Pula G, Mundell SJ, Roberts PJ, Kelly E. Agonist-independent internalization of metabotropic glutamate receptor 1a is arrestin- and clathrin-dependent and is suppressed by receptor inverse agonists. J. Neurochem. 2004 89 : 1009-1020. [PubMed]

14 Terstappen GC, Pellacani A, Aldegheri L, Graziani F, Carignani C, Pula G, Virginio C. The antidepressant fluoxetine blocks the human small conductance calcium-activated potassium channels SK1, SK2 and SK3. Neurosci. Lett. 2003 346 : 85-88. [PubMed]

15 Mundell SJ, Pula G, Carswell K, Roberts PJ, Kelly E. Agonist-induced internalization of metabotropic glutamate receptor 1A: structural determinants for protein kinase C- and G protein-coupled receptor kinase-mediated internalization. J. Neurochem. 2003 84 : 294-304. [PubMed]

16 Mundell SJ, Matharu AL, Pula G, Holman D, Roberts PJ, Kelly E. Metabotropic glutamate receptor 1 internalization induced by muscarinic acetylcholine receptor activation: differential dependency of internalization of splice variants on nonvisual arrestins. Mol. Pharmacol. 2002 61 : 1114-1123. [PubMed]

17 Mundell SJ, Matharu AL, Pula G, Roberts PJ, Kelly E. Agonist-induced internalization of the metabotropic glutamate receptor 1a is arrestin- and dynamin-dependent. J. Neurochem. 2001 78 : 546-551. [PubMed]

18 Terstappen GC, Pula G, Carignani C, Chen MX, Roncarati R. Pharmacological characterisation of the human small conductance calcium-activated potassium channel hSK3 reveals sensitivity to tricyclic antidepressants and antipsychotic phenothiazines. Neuropharmacology. 2001 40 : 772-783. [PubMed]